WormBase Tree Display for Gene: WBGene00007016
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| WBGene00007016 | Evidence | Author_evidence | Bourbon H-M | ||||||
|---|---|---|---|---|---|---|---|---|---|
| SMap | S_parent | Sequence | R12B2 | ||||||
| Identity | Version | 2 | |||||||
| Name | CGC_name | mdt-15 | |||||||
| Sequence_name | R12B2.5 | ||||||||
| Molecular_name | R12B2.5a | ||||||||
| R12B2.5a.1 | |||||||||
| CE30108 | |||||||||
| R12B2.5b | |||||||||
| CE25078 | |||||||||
| R12B2.5a.2 | |||||||||
| R12B2.5a.3 | |||||||||
| R12B2.5b.1 | |||||||||
| R12B2.5b.2 | |||||||||
| Other_name | CELE_R12B2.5 | Accession_evidence | NDB | BX284603 | |||||
| Public_name | mdt-15 | ||||||||
| DB_info | Database (11) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 14 May 2004 11:48:16 | WBPerson1845 | Event | Created | |||
| 2 | 02 Mar 2018 11:09:16 | WBPerson4025 | Event | Split_into | WBGene00303073 | ||||
| Split_into | WBGene00303073 | ||||||||
| Status | Live | ||||||||
| Gene_info (10) | |||||||||
| Disease_info | Experimental_model | DOID:0060413 | Homo sapiens | Paper_evidence | WBPaper00047004 | ||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 20 Sep 2018 00:00:00 | ||||||||
| Potential_model | DOID:5419 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:14248) | |||||
| Disease_relevance | 22q11.2 deletion syndrome (22q11.2DS) is the most common human deletion syndrome caused by deletion of a small piece of chromosome 22, characterized by neurodevelopmental defects, schizophrenia, congenital cardiac and craniofacial abnormalites (includes DiGeorge Syndrome and velocardiofacial syndrome); the 22q11.2 deletion overlaps several protein-coding genes including MED15 (mediator complex subunit 15); the C. elegans functional ortholog, mdt-15, is involved in fatty acid metabolism, the xenobiotic-induced expression of p38 MAP kinase PMK-1-dependent immune gene, and in oxidative stress responses; mutant phenotypes of mdt-15 include sterility, increased apoptosis, decreased protein expression, un-coordinated locomotion, and hypersensitivity to toxin exposure. | Homo sapiens | Paper_evidence | WBPaper00031850 | |||||
| WBPaper00045330 | |||||||||
| WBPaper00044077 | |||||||||
| WBPaper00027365 | |||||||||
| WBPaper00045290 | |||||||||
| Accession_evidence | OMIM | 611867 | |||||||
| 607372 | |||||||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 21 Sep 2015 00:00:00 | ||||||||
| Models_disease_in_annotation | WBDOannot00000374 | ||||||||
| Molecular_info | Corresponding_CDS | R12B2.5a | |||||||
| R12B2.5b | |||||||||
| Corresponding_CDS_history | R12B2.5c:wp264 | ||||||||
| Corresponding_transcript (5) | |||||||||
| Other_sequence (43) | |||||||||
| Associated_feature | WBsf651077 | ||||||||
| WBsf666928 | |||||||||
| WBsf978980 | |||||||||
| Experimental_info | RNAi_result (85) | ||||||||
| Expr_pattern (11) | |||||||||
| Drives_construct | WBCnstr00001928 | ||||||||
| WBCnstr00002264 | |||||||||
| WBCnstr00004278 | |||||||||
| WBCnstr00004334 | |||||||||
| WBCnstr00034035 | |||||||||
| WBCnstr00042004 | |||||||||
| Construct_product | WBCnstr00034035 | ||||||||
| Regulate_expr_cluster | WBPaper00031850:mdt-15(RNAi)_downregulated | ||||||||
| WBPaper00031850:mdt-15(RNAi)_upregulated | |||||||||
| WBPaper00048952:glucose_induced | |||||||||
| WBPaper00048952:glucose_repressed | |||||||||
| WBPaper00056290:mdt-15(mg584)_downregulated | |||||||||
| WBPaper00056290:mdt-15(mg584)_upregulated | |||||||||
| WBPaper00057158:mdt-15(tm2182)_dependent_15C_downregulated | |||||||||
| WBPaper00057158:mdt-15(tm2182)_dependent_15C_upregulated | |||||||||
| WBPaper00065288:mdt-15(tm2182)_downregulated | |||||||||
| WBPaper00065288:mdt-15(tm2182)_upregulated | |||||||||
| Antibody | WBAntibody00001868 | ||||||||
| WBAntibody00002490 | |||||||||
| Microarray_results (35) | |||||||||
| Expression_cluster (103) | |||||||||
| Interaction (135) | |||||||||
| WBProcess | WBbiopr:00000121 | ||||||||
| Map_info | Map | III | Position | -1.43929 | Error | 0.000147 | |||
| Positive | Positive_clone | R12B2 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Mapping_data | Multi_point | 5632 | |||||||
| Pseudo_map_position | |||||||||
| Reference (91) | |||||||||
| Picture | WBPicture0000013096 | ||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
