WormBase Tree Display for Gene: WBGene00006888
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| WBGene00006888 | Evidence | Person_evidence | WBPerson1827 | ||||||
|---|---|---|---|---|---|---|---|---|---|
| SMap | S_parent | Sequence | CHROMOSOME_I | ||||||
| Identity | Version | 1 | |||||||
| Name | CGC_name | vbh-1 | Person_evidence | WBPerson1827 | |||||
| Sequence_name | Y54E10A.9 | ||||||||
| Molecular_name | Y54E10A.9a | ||||||||
| Y54E10A.9a.1 | |||||||||
| CE24451 | |||||||||
| Y54E10A.9b | |||||||||
| CE28369 | |||||||||
| Y54E10A.9c | |||||||||
| CE37437 | |||||||||
| Y54E10A.9b.1 | |||||||||
| Y54E10A.9c.1 | |||||||||
| Y54E10A.9c.2 | |||||||||
| Other_name | CELE_Y54E10A.9 | Accession_evidence | NDB | BX284601 | |||||
| Public_name | vbh-1 | ||||||||
| DB_info | Database (13) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:43 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | vbh | ||||||||
| Allele (71) | |||||||||
| Strain | WBStrain00001725 | ||||||||
| WBStrain00035815 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (26) | |||||||||
| Ortholog (35) | |||||||||
| Paralog (37) | |||||||||
| Structured_description | Concise_description | vbh-1 encodes a DEAD-box RNA helicase with similarity to Drosophila Vasa and Belle; vbh-1 activity is required for the proper timing of the sperm-oocyte switch during germ line development; vbh-1 also plays a role in embryonic development; in regulating germ line development, vbh-1 appears to function at least partially redundantly with laf-1, which also encodes a DEAD-box RNA helicase; VBH-1 is expressed in the germline during oogenesis and spermatogenesis and is also found in somatic and germline blastomeres in the embryo; VBH-1 localizes to both the cytoplasm and to P granules; VBH-1 is also expressed in primary and secondary spermatocytes in the male gonad. | Paper_evidence | WBPaper00031012 | |||||
| WBPaper00033079 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 10 Jun 2010 00:00:00 | ||||||||
| Automated_description | Predicted to enable RNA binding activity and RNA helicase activity. Involved in developmental process involved in reproduction; positive regulation of embryonic development; and positive regulation of fertilization. Located in P granule and cytoplasmic stress granule. Expressed in several structures, including Z2; Z3; germ cell; somatic cell; and in male. Human ortholog(s) of this gene implicated in colorectal cancer; hepatocellular carcinoma; and syndromic X-linked intellectual disability. Is an ortholog of human DDX3X (DEAD-box helicase 3 X-linked). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:9256 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:2745) | ||||
| DOID:0060309 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:2745) | ||||||
| DOID:684 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:2745) | ||||||
| Molecular_info | Corresponding_CDS | Y54E10A.9a | |||||||
| Y54E10A.9b | |||||||||
| Y54E10A.9c | |||||||||
| Corresponding_transcript | Y54E10A.9a.1 | ||||||||
| Y54E10A.9b.1 | |||||||||
| Y54E10A.9c.1 | |||||||||
| Y54E10A.9c.2 | |||||||||
| Other_sequence (27) | |||||||||
| Associated_feature (16) | |||||||||
| Experimental_info | RNAi_result (13) | ||||||||
| Expr_pattern (13) | |||||||||
| Drives_construct | WBCnstr00002550 | ||||||||
| WBCnstr00019397 | |||||||||
| WBCnstr00019581 | |||||||||
| Construct_product | WBCnstr00019397 | ||||||||
| WBCnstr00019581 | |||||||||
| Antibody | WBAntibody00001300 | ||||||||
| WBAntibody00001301 | |||||||||
| WBAntibody00002358 | |||||||||
| Microarray_results (36) | |||||||||
| Expression_cluster (141) | |||||||||
| Interaction (171) | |||||||||
| Map_info | Map | I | Position | -4.4749 | Error | 0.000249 | |||
| Positive | Positive_clone | Y54E10A | Inferred_automatically | From CDS info | |||||
| From sequence, transcript, pseudogene data | |||||||||
| Mapping_data | Multi_point | 4749 | |||||||
| Pseudo_map_position | |||||||||
| Reference (15) | |||||||||
| Remark | This gene is highly similar to the RNA helicases VASA and BELLE from Drosophila. This worm helicase is germline specific and it is required for germline function. Its phenotype is based on RNAi hermaphrodites and males become sterile. | Person_evidence | WBPerson1827 | ||||||
| Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | ||||||||
| Method | Gene |
