WormBase Tree Display for Gene: WBGene00006721
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WBGene00006721 | Evidence | Person_evidence | WBPerson2549 | ||||||
---|---|---|---|---|---|---|---|---|---|
WBPerson6733 | |||||||||
SMap | S_parent | Sequence | F46E10 | ||||||
Identity | Version | 1 | |||||||
Name | CGC_name | ubh-1 | |||||||
Sequence_name | F46E10.8 | ||||||||
Molecular_name | F46E10.8 | ||||||||
F46E10.8.1 | |||||||||
CE20818 | |||||||||
Other_name | F46E10.f | Curator_confirmed | WBPerson1983 | ||||||
Remark | Old cosmid naming mapped via unique overlapping PCR_product on CDSs | ||||||||
CELE_F46E10.8 | Accession_evidence | NDB | BX284605 | ||||||
Public_name | ubh-1 | ||||||||
DB_info | Database (13) | ||||||||
Species | Caenorhabditis elegans | ||||||||
History | Version_change | 1 | 07 Apr 2004 11:29:41 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
Status | Live | ||||||||
Gene_info | Biotype | SO:0001217 | |||||||
Gene_class | ubh | ||||||||
Allele (25) | |||||||||
RNASeq_FPKM (74) | |||||||||
GO_annotation (21) | |||||||||
Contained_in_operon | CEOP5120 | ||||||||
Ortholog (39) | |||||||||
Paralog | WBGene00006722 | Caenorhabditis elegans | From_analysis | TreeFam | |||||
Panther | |||||||||
WormBase-Compara | |||||||||
WBGene00006723 | Caenorhabditis elegans | From_analysis | Panther | ||||||
WormBase-Compara | |||||||||
WBGene00006724 | Caenorhabditis elegans | From_analysis | Panther | ||||||
WormBase-Compara | |||||||||
Structured_description | Concise_description | ubh-1 encodes a putative ubiquitin C-terminal hydrolase orthologous to human UCHL1, that catalyzes the hydrolysis of C-terminal ubiquitinyl esters; C. elegans has three ubiquitin C-terminal hydrolase orthologs-ubh-1, ubh-2 and ubh-3; studies indicate that the ubh genes maybe be involved in aging, as they play a role in cellular senescence. | Paper_evidence | WBPaper00027616 | |||||
WBPaper00035660 | |||||||||
Curator_confirmed | WBPerson324 | ||||||||
WBPerson1823 | |||||||||
WBPerson567 | |||||||||
Date_last_updated | 15 Jul 2013 00:00:00 | ||||||||
Automated_description | Enables deNEDDylase activity and deubiquitinase activity. Involved in negative regulation of dauer larval development; positive regulation of transforming growth factor beta receptor signaling pathway; and protein deneddylation. Predicted to be located in cytoplasm. Expressed in amphid neurons and intestinal cell. Used to study Parkinson's disease. Human ortholog(s) of this gene implicated in Alzheimer's disease; Parkinson's disease; and hereditary spastic paraplegia (multiple). Is an ortholog of human UCHL1 (ubiquitin C-terminal hydrolase L1) and UCHL3 (ubiquitin C-terminal hydrolase L3). | Paper_evidence | WBPaper00065943 | ||||||
Curator_confirmed | WBPerson324 | ||||||||
WBPerson37462 | |||||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
Disease_info (3) | |||||||||
Models_disease_in_annotation | WBDOannot00000209 | ||||||||
Molecular_info | Corresponding_CDS | F46E10.8 | |||||||
Corresponding_transcript | F46E10.8.1 | ||||||||
Other_sequence (36) | |||||||||
Associated_feature | WBsf669046 | ||||||||
WBsf669047 | |||||||||
WBsf669048 | |||||||||
WBsf1000286 | |||||||||
WBsf233815 | |||||||||
Experimental_info | RNAi_result | WBRNAi00102982 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00102992 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00102972 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00015095 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00056335 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00094630 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00047527 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00076438 | Inferred_automatically | RNAi_primary | |||||||
Expr_pattern (5) | |||||||||
Drives_construct | WBCnstr00042221 | ||||||||
Construct_product | WBCnstr00042221 | ||||||||
Microarray_results (17) | |||||||||
Expression_cluster (153) | |||||||||
Interaction (17) | |||||||||
Map_info | Map | V | Position | -0.032234 | Error | 0.006589 | |||
Positive | Positive_clone | F46E10 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
Pseudo_map_position | |||||||||
Reference | WBPaper00010020 | ||||||||
WBPaper00025802 | |||||||||
WBPaper00027616 | |||||||||
WBPaper00030133 | |||||||||
WBPaper00030965 | |||||||||
WBPaper00038491 | |||||||||
WBPaper00055090 | |||||||||
WBPaper00060977 | |||||||||
WBPaper00063803 | |||||||||
WBPaper00064934 | |||||||||
Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
Method | Gene |