WormBase Tree Display for Gene: WBGene00006706
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WBGene00006706 | SMap | S_parent | Sequence | F29B9 | |||
---|---|---|---|---|---|---|---|
Identity (6) | |||||||
Gene_info | Biotype | SO:0001217 | |||||
Gene_class | ubc | ||||||
Allele (21) | |||||||
Strain | WBStrain00004050 | ||||||
WBStrain00034466 | |||||||
WBStrain00034467 | |||||||
RNASeq_FPKM (74) | |||||||
GO_annotation (33) | |||||||
Contained_in_operon | CEOP4128 | ||||||
Ortholog (41) | |||||||
Paralog (18) | |||||||
Structured_description | Concise_description | ubc-9 encodes an E2 ubiquitin-conjugating enzyme orthologous to Saccharomyces cerevisiae Ubc9p, which mediates the covalent attachment of the small ubiquitin-related modifier (SUMO) to various substrates including Ran-GAP1 and p53; UBC-9 activity is required for several developmental processes including embryogenesis, larval development, vulval development, posterior morphogenesis, and the DNA damage response (both DNA repair and DNA damage checkpoint function); UBC-9 interacts with LIN-1, an ETS-domain-containing transcription factor that negatively regulates vulval development, and with RAD-51, the C. elegans RecA homolog that is required for DNA repair. | Paper_evidence | WBPaper00005039 | |||
WBPaper00005337 | |||||||
WBPaper00012383 | |||||||
Curator_confirmed | WBPerson1843 | ||||||
Date_last_updated | 17 Jun 2004 00:00:00 | ||||||
Automated_description | Enables RNA polymerase II-specific DNA-binding transcription factor binding activity; SAM domain binding activity; and SUMO conjugating enzyme activity. Involved in several processes, including negative regulation of transcription by RNA polymerase II; pharyngeal muscle development; and protein sumoylation. Predicted to be located in nucleus. Expressed in body wall musculature; coelomocyte; pharynx; tail; and in male. Human ortholog(s) of this gene implicated in dilated cardiomyopathy; ovarian cancer; and urinary bladder cancer. Is an ortholog of human UBE2I (ubiquitin conjugating enzyme E2 I). | Paper_evidence | WBPaper00065943 | ||||
Curator_confirmed | WBPerson324 | ||||||
WBPerson37462 | |||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||
Disease_info | Potential_model (3) | ||||||
Molecular_info | Corresponding_CDS | F29B9.6 | |||||
Corresponding_transcript | F29B9.6.1 | ||||||
Other_sequence (69) | |||||||
Associated_feature | WBsf645940 | ||||||
WBsf645941 | |||||||
WBsf981746 | |||||||
WBsf996355 | |||||||
WBsf228217 | |||||||
WBsf228218 | |||||||
Experimental_info | RNAi_result (65) | ||||||
Expr_pattern | Expr11863 | ||||||
Expr13765 | |||||||
Expr1015118 | |||||||
Expr1032789 | |||||||
Expr1149806 | |||||||
Expr2017717 | |||||||
Expr2035855 | |||||||
Drives_construct | WBCnstr00019675 | ||||||
WBCnstr00034201 | |||||||
Construct_product | WBCnstr00034201 | ||||||
Regulate_expr_cluster | WBPaper00045390:ubc-9(RNAi)_downregulated | ||||||
WBPaper00045390:ubc-9(RNAi)_upregulated | |||||||
WBPaper00061479:ubc-9(ne4833)_upregulated | |||||||
Antibody | WBAntibody00002527 | ||||||
WBAntibody00002604 | |||||||
Microarray_results (28) | |||||||
Expression_cluster (150) | |||||||
Interaction (181) | |||||||
Map_info | Map | IV | Position | 0.518478 | Error | 0.015777 | |
Positive | Positive_clone | F29B9 | Inferred_automatically | From CDS info | |||
From sequence, transcript, pseudogene data | |||||||
Pseudo_map_position | |||||||
Reference (41) | |||||||
Remark | Sequence connection from [Jones D, Crowe E, Stevens TA, Candido EPM], 02/06/10 krb. | ||||||
Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | ||||||
Method | Gene |