WormBase Tree Display for Gene: WBGene00006406
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| WBGene00006406 | Evidence | CGC_data_submission | |||||||
|---|---|---|---|---|---|---|---|---|---|
| SMap | S_parent | Sequence | F12F6 | ||||||
| Identity | Version | 2 | |||||||
| Name | CGC_name | srgp-1 | Person_evidence | WBPerson240 | |||||
| WBPerson7529 | |||||||||
| Sequence_name | F12F6.5 | ||||||||
| Molecular_name (12) | |||||||||
| Other_name | tag-13 | Person_evidence | WBPerson201 | ||||||
| CELE_F12F6.5 | Accession_evidence | NDB | BX284604 | ||||||
| Public_name | srgp-1 | ||||||||
| DB_info | Database (11) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:40 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| 2 | 07 Jan 2008 09:52:10 | WBPerson2970 | Name_change | CGC_name | srgp-1 | ||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | srgp | ||||||||
| Allele (96) | |||||||||
| Strain | WBStrain00031361 | ||||||||
| WBStrain00037637 | |||||||||
| WBStrain00037679 | |||||||||
| WBStrain00037770 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (12) | |||||||||
| Contained_in_operon | CEOP4456 | ||||||||
| Ortholog (54) | |||||||||
| Structured_description | Concise_description | srgp-1 encodes the ortholog of the mammalian srGAP proteins, which are downstream effectors of the Slit-Robo neuronal guidance pathway and act as negative regulators of neuronal migration; srgp-1 positively regulates cell-cell adhesion during embryonic development and is required along with catenins, hmp-1 and hmp-2 for viability; srgp-1 also functions in engulfing cells to negatively regulate engulfment of apoptotic cells; SRGP-1 binds to and enhances CED-10/RAC GTPase activity via its GAP domain; SRGP-1 is expressed in head and tail neurons, pharynx and the spermatheca and localizes to adherens junctions. | Paper_evidence | WBPaper00037766 | |||||
| WBPaper00037900 | |||||||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 02 May 2011 00:00:00 | ||||||||
| Automated_description | Enables GTPase activator activity; protein self-association; and small GTPase binding activity. Involved in negative regulation of cell migration; negative regulation of phagocytosis, engulfment; and regulation of cell-cell adhesion. Located in adherens junction and cell cortex. Expressed in hypodermis; nerve ring; somatic cell; and spermatheca. Human ortholog(s) of this gene implicated in thyroid gland papillary carcinoma. Is an ortholog of human SRGAP1 (SLIT-ROBO Rho GTPase activating protein 1) and SRGAP2 (SLIT-ROBO Rho GTPase activating protein 2). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:3969 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:17382) | ||||
| Molecular_info | Corresponding_CDS | F12F6.5a | |||||||
| F12F6.5b | |||||||||
| F12F6.5c | |||||||||
| F12F6.5d | |||||||||
| Corresponding_transcript | F12F6.5a.1 | ||||||||
| F12F6.5b.1 | |||||||||
| F12F6.5c.1 | |||||||||
| F12F6.5d.1 | |||||||||
| Other_sequence (27) | |||||||||
| Associated_feature (21) | |||||||||
| Experimental_info | RNAi_result | WBRNAi00013170 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00086047 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00007762 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00086048 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00030859 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00077911 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00044452 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern | Chronogram41 | ||||||||
| Expr5745 | |||||||||
| Expr9226 | |||||||||
| Expr11575 | |||||||||
| Expr1015430 | |||||||||
| Expr1032598 | |||||||||
| Expr1148398 | |||||||||
| Expr2016357 | |||||||||
| Expr2034581 | |||||||||
| Drives_construct (15) | |||||||||
| Construct_product (16) | |||||||||
| Antibody | WBAntibody00002590 | ||||||||
| Microarray_results (22) | |||||||||
| Expression_cluster (139) | |||||||||
| Interaction (82) | |||||||||
| Map_info | Map | IV | Position | 5.0051 | Error | 0.001655 | |||
| Positive | Positive_clone | F12F6 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Mapping_data | Multi_point | 4487 | |||||||
| Pseudo_map_position | |||||||||
| Reference (13) | |||||||||
| Remark | Gene name created from parsing 'genotype' field from CGC strain information | CGC_data_submission | |||||||
| Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | ||||||||
| Method | Gene |
