WormBase Tree Display for Gene: WBGene00004911
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| WBGene00004911 | Evidence | CGC_data_submission | |||||||
|---|---|---|---|---|---|---|---|---|---|
| SMap | S_parent | Sequence | T25B6 | ||||||
| Identity | Version | 2 | |||||||
| Name | CGC_name | snf-12 | Person_evidence | WBPerson508 | |||||
| Sequence_name | T25B6.7 | ||||||||
| Molecular_name | T25B6.7 | ||||||||
| T25B6.7.1 | |||||||||
| CE29353 | |||||||||
| Other_name | nipi-2 | Paper_evidence | WBPaper00038424 | ||||||
| Person_evidence | WBPerson168 | ||||||||
| CELE_T25B6.7 | Accession_evidence | NDB | BX284606 | ||||||
| Public_name | snf-12 | ||||||||
| DB_info | Database | AceView | gene | XJ651 | |||||
| WormQTL | gene | WBGene00004911 | |||||||
| WormFlux | gene | WBGene00004911 | |||||||
| NDB | locus_tag | CELE_T25B6.7 | |||||||
| Panther | gene | CAEEL|WormBase=WBGene00004911|UniProtKB=O45813 | |||||||
| family | PTHR11616 | ||||||||
| NCBI | gene | 181143 | |||||||
| RefSeq | protein | NM_077126.4 | |||||||
| SwissProt | UniProtAcc | O45813 | |||||||
| UniProt_GCRP | UniProtAcc | O45813 | |||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:36 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Name_change | CGC_name | nipi-2 | |||||||
| 2 | 10 Jun 2011 15:00:48 | WBPerson2970 | Event | Acquires_merge | WBGene00077711 | ||||
| Name_change | CGC_name | snf-12 | |||||||
| Other_name | nipi-2 | ||||||||
| Acquires_merge | WBGene00077711 | ||||||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | snf | ||||||||
| Allele (72) | |||||||||
| Strain | WBStrain00021986 | ||||||||
| WBStrain00021987 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (12) | |||||||||
| Ortholog (28) | |||||||||
| Paralog (13) | |||||||||
| Structured_description | Concise_description | snf-12 encodes a transmembrane protein that is member of a highly conserved sodium-dependent neurotransmitter symporter family orthologous to mammalian sodium and chloride-dependent neurotransmitter transporters, or solute carrier 6 family (SLC6) members (OMIM: 610300); snf-12 is essential for a neuroendocrine TGF-beta and p38/MAPK immune signaling pathways; snf-12 is required cell autonomously for the response to infection in the epidermis, specifically for upregulating expression of nlp-29 and cnc-2 which encode anti-microbial peptides; SNF-12 is an atypical SLC6 protein that specifically regulates AMP gene expression; SNF-12 physical interacts with the STAT transcription factor-like protein STA-2 with which it functions to regulate antimicrobial gene expression downstream of a G protein/PKC delta pathway and partially downstream of p38/MAPK PMK-1; SNF-12 is expressed predominantly near the apical surface in epidermal cells in endosome-like vesicles where it colocalizes with STA-2; snf-12 is also expressed in the seam, excretory cell, and the amphid and phasmid socket cells. | Paper_evidence | WBPaper00038424 | |||||
| Curator_confirmed | WBPerson12884 | ||||||||
| WBPerson1843 | |||||||||
| Date_last_updated | 27 Jul 2011 00:00:00 | ||||||||
| Automated_description | Enables STAT family protein binding activity. Involved in positive regulation of antifungal peptide production. Located in apical part of cell and endocytic vesicle. Expressed in excretory cell; hypodermis; socket cell; and vulva. | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Molecular_info | Corresponding_CDS | T25B6.7 | |||||||
| Corresponding_transcript | T25B6.7.1 | ||||||||
| Other_sequence (11) | |||||||||
| Associated_feature | WBsf236115 | ||||||||
| Experimental_info | RNAi_result | WBRNAi00054102 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00000236 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00019192 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern | Expr9293 | ||||||||
| Expr9294 | |||||||||
| Expr1016500 | |||||||||
| Expr1032441 | |||||||||
| Expr1157646 | |||||||||
| Expr2015945 | |||||||||
| Expr2034180 | |||||||||
| Drives_construct | WBCnstr00008717 | ||||||||
| WBCnstr00008718 | |||||||||
| WBCnstr00035327 | |||||||||
| WBCnstr00041385 | |||||||||
| Construct_product | WBCnstr00008719 | ||||||||
| WBCnstr00008720 | |||||||||
| WBCnstr00008721 | |||||||||
| WBCnstr00008722 | |||||||||
| WBCnstr00008723 | |||||||||
| WBCnstr00035327 | |||||||||
| WBCnstr00041383 | |||||||||
| WBCnstr00041385 | |||||||||
| Microarray_results (19) | |||||||||
| Expression_cluster (104) | |||||||||
| Interaction (18) | |||||||||
| WBProcess | WBbiopr:00000039 | ||||||||
| Map_info | Map | X | Position | 0.566713 | Error | 0.042892 | |||
| Positive | Positive_clone | T25B6 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Mapping_data | Multi_point | 4150 | |||||||
| Pseudo_map_position | |||||||||
| Reference (13) | |||||||||
| Remark | Sequence connection from [Rand JB] | ||||||||
| Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | ||||||||
| Method | Gene |
