WormBase Tree Display for Gene: WBGene00004883
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| WBGene00004883 | SMap | S_parent | Sequence | W02D3 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | smg-5 | Person_evidence | WBPerson261 | |||||
| Sequence_name | W02D3.8 | ||||||||
| Molecular_name | W02D3.8 | ||||||||
| W02D3.8.1 | |||||||||
| CE25134 | |||||||||
| Other_name | mab-15 | ||||||||
| CELE_W02D3.8 | Accession_evidence | NDB | BX284601 | ||||||
| Public_name | smg-5 | ||||||||
| DB_info | Database | AceView | gene | 1H310 | |||||
| WormQTL | gene | WBGene00004883 | |||||||
| WormFlux | gene | WBGene00004883 | |||||||
| NDB | locus_tag | CELE_W02D3.8 | |||||||
| NCBI | gene | 172391 | |||||||
| RefSeq | protein | NM_059528.9 | |||||||
| TREEFAM | TREEFAM_ID | TF317574 | |||||||
| TrEMBL | UniProtAcc | G5ECF1 | |||||||
| UniProt_GCRP | UniProtAcc | G5ECF1 | |||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:36 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | smg | ||||||||
| Reference_allele | WBVar00241391 | ||||||||
| Allele (38) | |||||||||
| Legacy_information | See also r860 | ||||||||
| [C.elegansII] r860 : adult male has swollen bursa, adult hermaphrodite has protruding vulva. ME1. Recessive suppressor of unc-54(r293), tra-2(e1209), etc. unc-54 nonsense RNAs accumulate.OA1: r919::Tc1. Cloned: encodes 549 aa novel protein; 56 kD protein detected by western. In vitro and in vivo, SMG-5 interacts with SMG-7. [Hodgkin et al. 1989; Pulak and Anderson 1993; TR] | |||||||||
| Strain | WBStrain00034942 | ||||||||
| WBStrain00034944 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (13) | |||||||||
| Ortholog (19) | |||||||||
| Structured_description | Concise_description | smg-5 encodes a novel protein that contains two N-terminal tetratricopeptide (TPR) repeats and a C-terminal PINc domain found in nucleotide-binding proteins; SMG-5 is a component of the nonsense-mediated mRNA decay (NMD) pathway and likely functions in regulation of dephosphorylation of SMG-2, the C. elegans UPF1 ortholog, an ATPase and RNA helicase required for NMD in worms, yeast, and mammals; SMG-5 physically interacts with SMG-7, SMG-2, and the PAA-1 and LET-92 structural and catalytic subunits, respectively, of a protein phosphatase 2A (PP2A), suggesting that SMG-5 may function to direct SMG-2 to a PP2A phosphatase that regulates its activity in vivo; SMG-5 also interacts, in vivo, with components of the RNA interference (RNAi) pathway, suggesting a potential link between RNAi and NMD; SMG-5::GFP fusion proteins localize to both the nucleus and the cytoplasm. | Paper_evidence | WBPaper00005723 | |||||
| WBPaper00028417 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 18 Dec 2007 00:00:00 | ||||||||
| Automated_description | Enables DEAD/H-box RNA helicase binding activity and protein phosphatase 2A binding activity. Involved in embryonic genitalia morphogenesis; ncRNA metabolic process; and negative regulation of gene expression. Located in cytoplasm and nucleus. | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Molecular_info | Corresponding_CDS | W02D3.8 | |||||||
| Corresponding_transcript | W02D3.8.1 | ||||||||
| Other_sequence | CBC00894_1 | ||||||||
| CBC02474_1 | |||||||||
| CRC05694_1 | |||||||||
| CR10058 | |||||||||
| Associated_feature | WBsf219628 | ||||||||
| Experimental_info | RNAi_result | WBRNAi00085062 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00094394 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00008062 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00004377 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00094404 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00054593 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern | Expr1013450 | ||||||||
| Expr1032422 | |||||||||
| Expr1158137 | |||||||||
| Expr2015911 | |||||||||
| Expr2034144 | |||||||||
| Drives_construct | WBCnstr00035342 | ||||||||
| Construct_product | WBCnstr00017154 | ||||||||
| WBCnstr00017156 | |||||||||
| WBCnstr00017157 | |||||||||
| WBCnstr00017158 | |||||||||
| WBCnstr00035342 | |||||||||
| Microarray_results (18) | |||||||||
| Expression_cluster (82) | |||||||||
| Interaction (29) | |||||||||
| Map_info | Map | I | Position | 1.30166 | Error | 0.000313 | |||
| Well_ordered | |||||||||
| Positive | Positive_clone | W02D3 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Mapping_data | 2_point | 4745 | |||||||
| Multi_point | 1689 | ||||||||
| 1891 | |||||||||
| 1892 | |||||||||
| 2710 | |||||||||
| 4956 | |||||||||
| Reference (40) | |||||||||
| Method | Gene |
