WormBase Tree Display for Gene: WBGene00004798
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WBGene00004798 | SMap | S_parent | Sequence | F43D9 | ||
---|---|---|---|---|---|---|
Identity (6) | ||||||
Gene_info | Biotype | SO:0001217 | ||||
Gene_class | sip | |||||
Allele (18) | ||||||
Legacy_information | [C.elegansII] NMK. Expression in gonad and early embryo increased after treatment with > 0.2 mM cadmium. Encodes novel protein related to heat shock proteins. [CR] | |||||
RNASeq_FPKM (74) | ||||||
GO_annotation (12) | ||||||
Ortholog (36) | ||||||
Paralog (17) | ||||||
Structured_description | Concise_description | sip-1 encodes a member of the small heat shock family of proteins; loss of sip-1 function via antisense or large-scale RNAi experiments results in embryonic lethality and in a small but reproducible reduction in lifespan in otherwise long-lived animals, respectively, suggesting that sip-1 plays a role in embryonic development as well as regulation of adult lifespan; in addition, expression of sip-1 in E. coli is able to confer thermotolerance on the bacterium; sip-1 mRNA is detected in oocytes and developing embryos, with SIP-1 protein abundant and widely expressed in embryos that have not yet begun morphogenesis; sip-1 expression is regulated by the insulin/IGF-1 signaling (IIS) pathway. | Paper_evidence | WBPaper00002615 | ||
WBPaper00005976 | ||||||
WBPaper00006377 | ||||||
Curator_confirmed | WBPerson1843 | |||||
Date_last_updated | 23 Sep 2010 00:00:00 | |||||
Automated_description | Predicted to enable unfolded protein binding activity. Involved in several processes, including determination of adult lifespan; embryo development; and response to heat. Located in cytosol. Expressed in body wall musculature and gonad. | Paper_evidence | WBPaper00065943 | |||
Curator_confirmed | WBPerson324 | |||||
WBPerson37462 | ||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | |||||
Date_last_updated | 29 Nov 2023 00:00:00 | |||||
Molecular_info | Corresponding_CDS | F43D9.4 | ||||
Corresponding_transcript | F43D9.4.1 | |||||
Other_sequence (50) | ||||||
Associated_feature | WBsf651460 | |||||
WBsf667395 | ||||||
WBsf667396 | ||||||
WBsf976005 | ||||||
WBsf976006 | ||||||
WBsf976007 | ||||||
WBsf976008 | ||||||
WBsf976009 | ||||||
WBsf227467 | ||||||
WBsf227468 | ||||||
Experimental_info | RNAi_result (19) | |||||
Expr_pattern | Expr1607 | |||||
Expr1608 | ||||||
Expr12380 | ||||||
Expr14422 | ||||||
Expr15512 | ||||||
Expr1025283 | ||||||
Expr1032381 | ||||||
Expr1151051 | ||||||
Expr2015821 | ||||||
Expr2034054 | ||||||
Drives_construct | WBCnstr00035382 | |||||
WBCnstr00040852 | ||||||
WBCnstr00042203 | ||||||
Construct_product | WBCnstr00035382 | |||||
WBCnstr00042203 | ||||||
Antibody | WBAntibody00001798 | |||||
Microarray_results (21) | ||||||
Expression_cluster (325) | ||||||
Interaction (1036) | ||||||
WBProcess | WBbiopr:00000053 | |||||
Map_info (4) | ||||||
Reference (32) | ||||||
Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | ||||
Method | Gene |