WormBase Tree Display for Gene: WBGene00004780
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| WBGene00004780 | Evidence | Person_evidence | WBPerson2171 | ||||||
|---|---|---|---|---|---|---|---|---|---|
| SMap | S_parent | Sequence | CHROMOSOME_X | ||||||
| Identity | Version | 1 | |||||||
| Name | CGC_name | ser-7 | Person_evidence | WBPerson32 | |||||
| Sequence_name | C09B7.1 | ||||||||
| Molecular_name | C09B7.1a | ||||||||
| C09B7.1a.1 | |||||||||
| CE28532 | |||||||||
| C09B7.1b | |||||||||
| CE30332 | |||||||||
| C09B7.1c | |||||||||
| CE17391 | |||||||||
| C09B7.1b.1 | |||||||||
| C09B7.1c.1 | |||||||||
| Other_name | CELE_C09B7.1 | Accession_evidence | NDB | BX284606 | |||||
| Public_name | ser-7 | ||||||||
| DB_info | Database | AceView | gene | XD299 | |||||
| WormQTL | gene | WBGene00004780 | |||||||
| WormFlux | gene | WBGene00004780 | |||||||
| NDB | locus_tag | CELE_C09B7.1 | |||||||
| Panther | gene | CAEEL|WormBase=WBGene00004780|UniProtKB=Q22895 | |||||||
| family | PTHR24247 | ||||||||
| NCBI | gene | 180565 | |||||||
| RefSeq | protein | NM_171941.7 | |||||||
| NM_171637.6 | |||||||||
| NM_001029202.6 | |||||||||
| TrEMBL | UniProtAcc | Q86GT6 | |||||||
| Q22895 | |||||||||
| Q8T3C1 | |||||||||
| UniProt_GCRP | UniProtAcc | Q22895 | |||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:36 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | ser | ||||||||
| Allele (148) | |||||||||
| Strain (14) | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (19) | |||||||||
| Ortholog (19) | |||||||||
| Paralog (14) | |||||||||
| Structured_description | Concise_description | ser-7 encodes an ortholog of mammalian 5-HT7 metabotropic serotoninreceptors; SER-7 is required for stimulation of egg-laying or pharyngealpumping by serotonin (5-HT), for regular pumping in response tobacteria, and probably also for 5-HT to activate MC neurons; SER-7 andSER-1 are redundantly required for normal egg-laying; SER-7 is expressedin head and tail neurons, pharyngeal neurons (M4, MCs, I2s, I3, M5, M3s,I4, I6, and M2s), vulval muscles, and intestine; heterologouslyexpressed SER-7, when challenged with 5-HT, stimulates intracellularadenylate cyclase activity; SER-7 has high affinity for 5-HT andtryptamine, but not for 5-CT, and is unaffected by at least someagonists of mammalian 5-HT7 receptors. | Paper_evidence | WBPaper00006080 | |||||
| WBPaper00006525 | |||||||||
| WBPaper00024420 | |||||||||
| WBPaper00024527 | |||||||||
| WBPaper00026667 | |||||||||
| WBPaper00026843 | |||||||||
| WBPaper00028762 | |||||||||
| Curator_confirmed | WBPerson567 | ||||||||
| Date_last_updated | 20 Dec 2006 00:00:00 | ||||||||
| Automated_description | Predicted to enable G protein-coupled serotonin receptor activity and neurotransmitter receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger and chemical synaptic transmission. Located in membrane. Expressed in pharyngeal neurons and vulval muscle. Human ortholog(s) of this gene implicated in alcohol use disorder. Is an ortholog of human HTR7 (5-hydroxytryptamine receptor 7). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:1574 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:5302) | ||||
| Molecular_info | Corresponding_CDS | C09B7.1a | |||||||
| C09B7.1b | |||||||||
| C09B7.1c | |||||||||
| Corresponding_transcript | C09B7.1a.1 | ||||||||
| C09B7.1b.1 | |||||||||
| C09B7.1c.1 | |||||||||
| Other_sequence (19) | |||||||||
| Associated_feature | WBsf662543 | ||||||||
| WBsf1004399 | |||||||||
| WBsf1004400 | |||||||||
| WBsf1004401 | |||||||||
| WBsf1022498 | |||||||||
| WBsf1022499 | |||||||||
| WBsf235406 | |||||||||
| Experimental_info | RNAi_result (19) | ||||||||
| Expr_pattern (12) | |||||||||
| Drives_construct | WBCnstr00000005 | ||||||||
| WBCnstr00000453 | |||||||||
| WBCnstr00002111 | |||||||||
| WBCnstr00003417 | |||||||||
| WBCnstr00010899 | |||||||||
| WBCnstr00011927 | |||||||||
| WBCnstr00014553 | |||||||||
| WBCnstr00035392 | |||||||||
| WBCnstr00043012 | |||||||||
| Construct_product | WBCnstr00009967 | ||||||||
| WBCnstr00011557 | |||||||||
| WBCnstr00014553 | |||||||||
| WBCnstr00022693 | |||||||||
| WBCnstr00022698 | |||||||||
| WBCnstr00035392 | |||||||||
| WBCnstr00040529 | |||||||||
| WBCnstr00043012 | |||||||||
| Microarray_results (33) | |||||||||
| Expression_cluster (130) | |||||||||
| Interaction (18) | |||||||||
| Map_info | Map | X | Position | -14.0401 | Error | 0.077581 | |||
| Positive | Positive_clone | C09B7 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Mapping_data | Multi_point | 4832 | |||||||
| 4796 | |||||||||
| 4787 | |||||||||
| Pseudo_map_position | |||||||||
| Reference (69) | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
