WormBase Tree Display for Gene: WBGene00004754
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WBGene00004754 | SMap | S_parent | Sequence | Y113G7A | |||
---|---|---|---|---|---|---|---|
Identity (6) | |||||||
Gene_info | Biotype | SO:0001217 | |||||
Gene_class | sec | ||||||
Allele (341) | |||||||
Strain | WBStrain00008607 | ||||||
RNASeq_FPKM (74) | |||||||
GO_annotation (19) | |||||||
Ortholog (44) | |||||||
Structured_description | Concise_description | sec-23 encodes a component of COPII (coat protein complex II)-coated vesicles orthologous to Saccharomyces cerevisiae Sec23p; by homology, SEC-23 is predicted to be involved in endoplasmic reticulum (ER)-to-Golgi transport; loss of sec-23 activity results in defects in oogenesis, morphogenesis, and extracellular matrix secretion; a SEC-23::GFP fusion protein localizes to the apical region of the endoplasmic reticulum of hypodermal cells, consistent with localization to endoplasmic reticulum exit sites. | Paper_evidence | WBPaper00006236 | |||
Curator_confirmed | WBPerson1843 | ||||||
Date_last_updated | 02 May 2014 00:00:00 | ||||||
Automated_description | Predicted to enable GTPase activator activity. Predicted to be involved in COPII-coated vesicle cargo loading. Located in endoplasmic reticulum exit site. Expressed in hypodermis. Human ortholog(s) of this gene implicated in Cowden syndrome 7; congenital dyserythropoietic anemia type II; and craniolenticulosutural dysplasia. Is an ortholog of human SEC23B (SEC23 homolog B, COPII coat complex component). | Paper_evidence | WBPaper00065943 | ||||
Curator_confirmed | WBPerson324 | ||||||
WBPerson37462 | |||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||
Disease_info | Potential_model | DOID:0081003 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:10702) | ||
DOID:0070307 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:10701) | ||||
DOID:0111401 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:10702) | ||||
Molecular_info | Corresponding_CDS | Y113G7A.3 | |||||
Corresponding_CDS_history | Y113G7A.3:wp47 | ||||||
Corresponding_transcript | Y113G7A.3.1 | ||||||
Other_sequence (54) | |||||||
Associated_feature (17) | |||||||
Experimental_info | RNAi_result (29) | ||||||
Expr_pattern | Expr2790 | ||||||
Expr1022212 | |||||||
Expr1032351 | |||||||
Expr1158901 | |||||||
Expr2015713 | |||||||
Expr2033945 | |||||||
Drives_construct | WBCnstr00004952 | ||||||
WBCnstr00010950 | |||||||
Construct_product | WBCnstr00010950 | ||||||
Microarray_results (23) | |||||||
Expression_cluster (122) | |||||||
Interaction (129) | |||||||
Anatomy_function | WBbtf0239 | ||||||
Map_info | Map | V | Position | 24.7157 | Error | 0.024791 | |
Positive | Positive_clone | Y113G7A | Inferred_automatically | From CDS info | |||
From sequence, transcript, pseudogene data | |||||||
Mapping_data | Multi_point | 4325 | |||||
4800 | |||||||
5484 | |||||||
Pseudo_map_position | |||||||
Reference (17) | |||||||
Remark (2) | |||||||
Method | Gene |