WormBase Tree Display for Gene: WBGene00004742

WBGene00004742 Evidence: Paper_evidence: WBPaper00005759
  SMap: S_parent: Sequence: F49E11
  Identity: Version: 1
    Name: CGC_name: scl-1
      Sequence_name: F49E11.9
      Molecular_name: F49E11.9
        F49E11.9.1
        CE05905
      Other_name: CELE_F49E11.9 Accession_evidence: NDB BX284604
      Public_name: scl-1
    DB_info: Database: AceView gene 4N819
        WormQTL gene WBGene00004742
        WormFlux gene WBGene00004742
        NDB locus_tag CELE_F49E11.9
        Panther gene CAEEL|WormBase=WBGene00004742|UniProtKB=Q20608
          family PTHR10334
        NCBI gene 186053
        RefSeq protein NM_070101.3
        TREEFAM TREEFAM_ID TF352352
        TrEMBL UniProtAcc Q20608
        UniProt_GCRP UniProtAcc Q20608
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:36 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: scl
    Allele (27)
    Strain: WBStrain00031857
    RNASeq_FPKM (74)
    GO_annotation: 00068515
      00068516
      00068517
      00068518
    Ortholog (64)
    Paralog (32)
    Structured_description: Concise_description: scl-1 encodes a predicted secretory protein that is a member of the cysteine-rich secretory protein (CRISP) family; scl-1 activity positively regulates longevity and stress resistance; in wild-type animals, scl-1 mRNA is detected solely in eggs, while in daf-2 mutants it is detected in eggs and late adult stages; scl-1 expression appears to be under the control of the DAF-2/insulin-like signaling pathway as, in mixed-stage cultures, scl-1 mRNA levels are increased in daf-2 and age-1 mutants and undetectable in daf-16 mutants; scl-1 contains a DAF-16 consensus binding element within its predicted regulatory regions. Paper_evidence: WBPaper00005759
          Curator_confirmed: WBPerson1843
          Date_last_updated: 02 Mar 2007 00:00:00
      Automated_description: Involved in determination of adult lifespan; response to UV; and response to heat. Predicted to be located in extracellular space. Is an ortholog of human PI15 (peptidase inhibitor 15). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Molecular_info: Corresponding_CDS: F49E11.9
    Corresponding_transcript: F49E11.9.1
  Experimental_info: RNAi_result: WBRNAi00022902 Inferred_automatically: RNAi_primary
      WBRNAi00047848 Inferred_automatically: RNAi_primary
      WBRNAi00015315 Inferred_automatically: RNAi_primary
    Expr_pattern: Expr16184
      Expr1020109
      Expr1151681
      Expr2015631
      Expr2033866
    Drives_construct: WBCnstr00035416
    Construct_product: WBCnstr00035416
    Microarray_results (18)
    Expression_cluster (35)
    Interaction (37)
  Map_info: Map: IV Position: 7.59753 Error: 0.028914
    Positive: Positive_clone: F49E11 Inferred_automatically: From CDS info
            From sequence, transcript, pseudogene data
    Mapping_data: Multi_point: 4871
        4831
        4862
    Pseudo_map_position
  Reference (12)
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene