WormBase Tree Display for Gene: WBGene00004737
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WBGene00004737 | Evidence | CGC_data_submission | |||||
---|---|---|---|---|---|---|---|
SMap | S_parent | Sequence | F10G7 | ||||
Identity (6) | |||||||
Gene_info | Biotype | SO:0001217 | |||||
Gene_class | scc | ||||||
Allele (26) | |||||||
Legacy_information | [J. Loidl] RNAi phenotypes : ~98% embryo lethality, HIM (~3% males); protein localizes to somatic nuclei of the embryo and to nuclei at meiotic prophase | ||||||
[J. Loidl] (F10G7.4) is homolog to the Rad21/Scc1/Rec8 family of cohesion proteins with knownmembers in S. cerevisiae, S. pombe, A. thaliana and vertebrates. R-S-R is the acronym of the founder family. | |||||||
Strain | WBStrain00035987 | ||||||
RNASeq_FPKM (74) | |||||||
GO_annotation (20) | |||||||
Ortholog (44) | |||||||
Paralog | WBGene00000591 | Caenorhabditis elegans | From_analysis | TreeFam | |||
WormBase-Compara | |||||||
Structured_description | Concise_description | scc-1 encodes a member of the Rad21/Rec8-like family of cohesion proteins that affects embryonic viability, fertility, the rate of embryonic cell divisions and the incidence of male progeny; interacts with ATL-1, F56D12.5, and F11E6.1 based on yeast two-hybrid assays, and is expressed in nondividing embryonic and germline nuclei. | Paper_evidence | WBPaper00004651 | |||
WBPaper00004722 | |||||||
WBPaper00005039 | |||||||
WBPaper00018377 | |||||||
Curator_confirmed | WBPerson48 | ||||||
Date_last_updated | 17 Jun 2004 00:00:00 | ||||||
Automated_description | Predicted to enable chromatin binding activity and damaged DNA binding activity. Involved in meiotic cell cycle. Located in nucleus. Part of cohesin complex. Expressed in several structures, including SDQ; germ line; seam cell; touch receptor neurons; and ventral nerve cord. Human ortholog(s) of this gene implicated in Cornelia de Lange syndrome 4; carcinoma (multiple); and endometrial cancer. Is an ortholog of human RAD21 (RAD21 cohesin complex component) and RAD21L1 (RAD21 cohesin complex component like 1). | Paper_evidence | WBPaper00065943 | ||||
Curator_confirmed | WBPerson324 | ||||||
WBPerson37462 | |||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||
Disease_info | Potential_model | DOID:0080508 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:9811) | ||
DOID:0050866 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:9811) | ||||
DOID:3908 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:9811) | ||||
DOID:0080199 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:9811) | ||||
DOID:684 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:9811) | ||||
DOID:1380 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:9811) | ||||
Molecular_info | Corresponding_CDS | F10G7.4 | |||||
Corresponding_transcript | F10G7.4.1 | ||||||
Other_sequence | CRC06495_1 | ||||||
MP00107 | |||||||
BXC03089_1 | |||||||
CBC02363_1 | |||||||
MI06164 | |||||||
CJC04977_1 | |||||||
CR03754 | |||||||
RSC00091_1 | |||||||
CJC01832_1 | |||||||
MIC05797_1 | |||||||
Associated_feature (3) | |||||||
Experimental_info | RNAi_result (17) | ||||||
Expr_pattern | Expr1350 | ||||||
Expr2579 | |||||||
Expr11962 | |||||||
Expr1015315 | |||||||
Expr1032337 | |||||||
Expr1148255 | |||||||
Expr2015621 | |||||||
Expr2033856 | |||||||
Drives_construct | WBCnstr00035420 | ||||||
Construct_product | WBCnstr00035420 | ||||||
Antibody | WBAntibody00000375 | ||||||
WBAntibody00000636 | |||||||
WBAntibody00000645 | |||||||
WBAntibody00000646 | |||||||
Microarray_results (19) | |||||||
Expression_cluster (151) | |||||||
Interaction (107) | |||||||
WBProcess | WBbiopr:00000099 | ||||||
Map_info | Map | II | Position | -3.59162 | Error | 0.111344 | |
Positive | Positive_clone | F10G7 | Inferred_automatically | From sequence, transcript, pseudogene data | |||
Mapping_data | Multi_point | 4996 | |||||
Pseudo_map_position | |||||||
Reference (13) | |||||||
Remark | Sequence connection from [Sugimoto A] | ||||||
Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | ||||||
Method | Gene |