WormBase Tree Display for Gene: WBGene00004402

WBGene00004402 Evidence: Paper_evidence: WBPaper00018136
  SMap: S_parent: Sequence: Y116A8C
  Identity: Version: 1
    Name: CGC_name: rom-3 Person_evidence: WBPerson232
      Sequence_name: Y116A8C.14
      Molecular_name: Y116A8C.14a
        Y116A8C.14a.1
        CE39642
        Y116A8C.14b
        CE50609
        Y116A8C.14b.1
      Other_name: CELE_Y116A8C.14 Accession_evidence: NDB BX284604
      Public_name: rom-3
    DB_info: Database: AceView gene 4R906
        WormQTL gene WBGene00004402
        WormFlux gene WBGene00004402
        NDB locus_tag CELE_Y116A8C.14
        Panther gene CAEEL|EnsemblGenome=WBGene00004402|UniProtKB=Q9U2S3
          family PTHR45965
        NCBI gene 191000
        RefSeq protein NM_070612.2
            NM_001313037.1
        TrEMBL UniProtAcc A0A0K3AV34
            Q9U2S3
        UniProt_GCRP UniProtAcc Q9U2S3
        OMIM gene 614404
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:35 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: rom
    Allele (163)
    RNASeq_FPKM (74)
    GO_annotation: 00001380
      00001381
      00001382
      00001383
      00099565
      00099566
      00099567
      00099568
      00112780
      00112781
    Ortholog (36)
    Paralog: WBGene00020683 Caenorhabditis elegans From_analysis: TreeFam
      WBGene00004403 Caenorhabditis elegans From_analysis: TreeFam
            Panther
            WormBase-Compara
      WBGene00004400 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00004401 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00004404 Caenorhabditis elegans From_analysis: WormBase-Compara
    Structured_description: Automated_description: Predicted to enable serine-type endopeptidase activity. Predicted to be involved in regulation of epidermal growth factor receptor signaling pathway and regulation of protein secretion. Predicted to be located in endoplasmic reticulum membrane. Human ortholog(s) of this gene implicated in palmoplantar keratoderma-esophageal carcinoma syndrome. Is an ortholog of human RHBDF1 (rhomboid 5 homolog 1) and RHBDF2 (rhomboid 5 homolog 2). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:0111506 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:20788)
  Molecular_info: Corresponding_CDS: Y116A8C.14a
      Y116A8C.14b
    Corresponding_CDS_history: Y116A8C.14:wp153
    Corresponding_transcript: Y116A8C.14a.1
      Y116A8C.14b.1
    Other_sequence (12)
    Associated_feature: WBsf1018935
  Experimental_info: RNAi_result: WBRNAi00055430 Inferred_automatically: RNAi_primary
      WBRNAi00019916 Inferred_automatically: RNAi_primary
      WBRNAi00062579 Inferred_automatically: RNAi_primary
    Expr_pattern: Expr1027458
      Expr1158944
      Expr2015408
      Expr2033643
    Microarray_results (18)
    Expression_cluster (90)
    Interaction (32)
  Map_info: Map: IV Position: 15.8195 Error: 0.008429
    Positive: Positive_clone: Y116A8C Inferred_automatically: From CDS info
            From sequence, transcript, pseudogene data
    Pseudo_map_position
  Reference: WBPaper00011463
    WBPaper00018136
    WBPaper00024876
    WBPaper00038491
    WBPaper00055090
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene