WormBase Tree Display for Gene: WBGene00004333
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WBGene00004333 | Evidence | CGC_data_submission | |||||
---|---|---|---|---|---|---|---|
SMap | S_parent | Sequence | W02A2 | ||||
Identity (6) | |||||||
Gene_info | Biotype | SO:0001217 | |||||
Gene_class | rec | ||||||
Allele (63) | |||||||
Legacy_information | RNAi phenotypes: >90% embryonic lethality, HIM (11% males); loss of meiotic chromosome pairing and sister chromatid cohesion; meiotic nondisjunction; protein localizes to axes of chromosomes at meiotic prophase | ||||||
Strain | WBStrain00035158 | ||||||
WBStrain00035162 | |||||||
WBStrain00035163 | |||||||
WBStrain00035963 | |||||||
RNASeq_FPKM (74) | |||||||
GO_annotation (34) | |||||||
Ortholog (19) | |||||||
Structured_description | Concise_description | rec-8 encodes a meiosis-specific cohesin complex subunit orthologous to Saccharomyces cerevisiae and Schizosaccharomyces pombe Rec8p; REC-8 is essential for pairing of homologoues and sister chromatids during meiosis and thus for proper chromosome disjunction; in the germline, REC-8 associates with chromatin of transition zone nuclei, and co-localizes with SMC-1 along the longitudinal axes of synapsed chromosomes at pachytene and in a cruciform pattern at diakinesis; REC-8 localization to chromatin is dependent upon TIM-1, a HEAT/Armadillo repeat-containing protein related to Drosophila TIMELESS, and additionally, REC-8 and SCC-3 are mutually required for chromatin localization; REC-8 cleavage and degradation during meiosis I is dependent on the AIR-2 aurora-like kinase and during meiosis II on AIR-2 and the PLK-1 polo-like kinase. | Paper_evidence | WBPaper00004722 | |||
WBPaper00004997 | |||||||
WBPaper00005919 | |||||||
WBPaper00006163 | |||||||
WBPaper00018756 | |||||||
WBPaper00019729 | |||||||
Curator_confirmed | WBPerson1843 | ||||||
Date_last_updated | 17 Jun 2004 00:00:00 | ||||||
Automated_description | Predicted to enable chromatin binding activity and damaged DNA binding activity. Involved in double-strand break repair and organelle organization. Located in nuclear lumen and spindle. Part of chromatin. Expressed in Z2; Z3; embryonic cell; and gonad. | Paper_evidence | WBPaper00065943 | ||||
Curator_confirmed | WBPerson324 | ||||||
WBPerson37462 | |||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||
Molecular_info | Corresponding_CDS | W02A2.6a | |||||
W02A2.6b | |||||||
W02A2.6c | |||||||
Corresponding_transcript | W02A2.6a.1 | ||||||
W02A2.6b.1 | |||||||
W02A2.6c.1 | |||||||
Other_sequence (4) | |||||||
Associated_feature | WBsf668473 | ||||||
WBsf998389 | |||||||
WBsf1018520 | |||||||
WBsf231115 | |||||||
WBsf231116 | |||||||
Experimental_info | RNAi_result (25) | ||||||
Expr_pattern | Expr2451 | ||||||
Expr11542 | |||||||
Expr12238 | |||||||
Expr16473 | |||||||
Expr1017580 | |||||||
Expr1032151 | |||||||
Expr1158093 | |||||||
Expr2015291 | |||||||
Expr2033525 | |||||||
Drives_construct | WBCnstr00035561 | ||||||
Construct_product | WBCnstr00035561 | ||||||
Antibody (15) | |||||||
Microarray_results (21) | |||||||
Expression_cluster (125) | |||||||
Interaction (83) | |||||||
WBProcess | WBbiopr:00000099 | ||||||
Map_info | Map | IV | Position | 8.53422 | Error | 0.001584 | |
Positive | Positive_clone | W02A2 | Inferred_automatically | From sequence, transcript, pseudogene data | |||
Mapping_data | Multi_point | 4298 | |||||
Pseudo_map_position | |||||||
Reference (75) | |||||||
Remark | [J. Loidl] rec-8 (W02A2.6) is the likely ortholog of S. cerevisiae rec8 meiosis-specific cohesion protein | ||||||
Sequence connection from [Loidl J] | |||||||
Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | ||||||
Method | Gene |