WormBase Tree Display for Gene: WBGene00004302
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WBGene00004302 | SMap | S_parent | Sequence | K01G5 | |||||
---|---|---|---|---|---|---|---|---|---|
Identity | Version | 1 | |||||||
Name | CGC_name | ran-1 | |||||||
Sequence_name | K01G5.4 | ||||||||
Molecular_name | K01G5.4 | ||||||||
K01G5.4.1 | |||||||||
CE16194 | |||||||||
Other_name | CELE_K01G5.4 | Accession_evidence | NDB | BX284603 | |||||
Public_name | ran-1 | ||||||||
DB_info | Database | AceView | gene | 3L836 | |||||
WormQTL | gene | WBGene00004302 | |||||||
WormFlux | gene | WBGene00004302 | |||||||
NDB | locus_tag | CELE_K01G5.4 | |||||||
Panther | gene | CAEEL|WormBase=WBGene00004302|UniProtKB=O17915 | |||||||
family | PTHR24071 | ||||||||
NCBI | gene | 176503 | |||||||
RefSeq | protein | NM_066968.8 | |||||||
SwissProt | UniProtAcc | O17915 | |||||||
TREEFAM | TREEFAM_ID | TF106302 | |||||||
UniProt_GCRP | UniProtAcc | O17915 | |||||||
Species | Caenorhabditis elegans | ||||||||
History | Version_change | 1 | 07 Apr 2004 11:29:34 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
Status | Live | ||||||||
Gene_info | Biotype | SO:0001217 | |||||||
Gene_class | ran | ||||||||
Allele (19) | |||||||||
RNASeq_FPKM (74) | |||||||||
GO_annotation (23) | |||||||||
Ortholog (43) | |||||||||
Structured_description | Concise_description | ran-1 encodes the C. elegans Ran GTPase ortholog; ran-1 activity is essential for proper mitotic spindle formation, effective connection between centrosomes and the male pronucleus, nuclear envelope assembly after cell division, and oocyte meiotic maturation; in regulating nuclear envelope dynamics, ran-1 appears to function upstream of MEL-28 by regulating its localization to the nuclear periphery; in regulating oocyte meiotic maturation, RAN-1 interacts with VAB-1 MSP/Eph and regulates its localization to endocytic-recycling vesicles in the absence of the major sperm protein (MSP)/sperm; in dissected gonads and oocytes, RAN-1 staining is detected at the cortex. | Paper_evidence | WBPaper00005637 | |||||
WBPaper00028457 | |||||||||
WBPaper00031867 | |||||||||
Curator_confirmed | WBPerson1843 | ||||||||
Date_last_updated | 13 May 2008 00:00:00 | ||||||||
Automated_description | Predicted to enable GTPase activity. Involved in embryo development and oogenesis. Predicted to be located in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in type 1 diabetes mellitus. Is an ortholog of human RAN (RAN, member RAS oncogene family). | Paper_evidence | WBPaper00065943 | ||||||
Curator_confirmed | WBPerson324 | ||||||||
WBPerson37462 | |||||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
Disease_info | Potential_model | DOID:9744 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:9846) | ||||
Molecular_info | Corresponding_CDS | K01G5.4 | |||||||
Corresponding_transcript | K01G5.4.1 | ||||||||
Other_sequence (143) | |||||||||
Associated_feature (16) | |||||||||
Experimental_info | RNAi_result (30) | ||||||||
Expr_pattern | Expr11867 | ||||||||
Expr1017913 | |||||||||
Expr1032127 | |||||||||
Expr1153362 | |||||||||
Expr2015250 | |||||||||
Expr2033484 | |||||||||
Drives_construct | WBCnstr00035579 | ||||||||
Construct_product | WBCnstr00035579 | ||||||||
Microarray_results (25) | |||||||||
Expression_cluster (217) | |||||||||
Interaction (481) | |||||||||
WBProcess | WBbiopr:00000120 | ||||||||
Map_info | Map | III | Position | 5.17476 | Error | 0.025579 | |||
Positive | Positive_clone | K01G5 | Inferred_automatically | From CDS info | |||||
From sequence, transcript, pseudogene data | |||||||||
Pseudo_map_position | |||||||||
Reference (24) | |||||||||
Remark | Sequence connection from [Askjaer P, Mattaj IW]. krb 13/11/01 | ||||||||
Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | ||||||||
Method | Gene |