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WormBase Tree Display for Gene: WBGene00004286

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Name Class

WBGene00004286SMapS_parentSequenceD2013
IdentityVersion1
NameCGC_namerab-39Person_evidenceWBPerson451
Sequence_nameD2013.1
Molecular_name (3)
Other_nameCELE_D2013.1Accession_evidenceNDBBX284602
Public_namerab-39
DB_infoDatabaseAceViewgene2J612
WormQTLgeneWBGene00004286
WormFluxgeneWBGene00004286
NDBlocus_tagCELE_D2013.1
PanthergeneCAEEL|WormBase=WBGene00004286|UniProtKB=Q18969
familyPTHR47979
NCBIgene183941
RefSeqproteinNM_063583.4
SwissProtUniProtAccQ18969
UniProt_GCRPUniProtAccQ18969
OMIMgene300774
SpeciesCaenorhabditis elegans
HistoryVersion_change107 Apr 2004 11:29:34WBPerson1971EventImportedInitial conversion from geneace
StatusLive
Gene_infoBiotypeSO:0001217
Gene_classrab
Allele (29)
StrainWBStrain00055386
RNASeq_FPKM (74)
GO_annotation (18)
Ortholog (45)
Paralog (32)
Structured_descriptionConcise_descriptionrab-39 encodes a small, monomeric Rab GTPase that is most closely related to the human and Drosophila Rab39 GTPases; by homology, RAB-39 is predicted to function as a membrane-associated GTPase required for intracellular vesicular trafficking and for regulation of endo- and exocytosis; however, as loss of rab-39 function via RNA-mediated interference (RNAi) does not result in any obvious abnormalities, the precise role of RAB-39 in C. elegans development and/or behavior is not yet known.Paper_evidenceWBPaper00004968
WBPaper00005654
WBPaper00015788
Curator_confirmedWBPerson1843
Date_last_updated17 Jun 2004 00:00:00
Automated_descriptionEnables GTP binding activity. Involved in positive regulation of response to oxidative stress. Predicted to be located in Golgi apparatus; cytoplasmic vesicle membrane; and plasma membrane. Expressed in head mesodermal cell; head neurons; hypodermis; rectal gland cell; and tail neurons. Human ortholog(s) of this gene implicated in Waisman syndrome and non-syndromic X-linked intellectual disability 72. Is an ortholog of human RAB39A (RAB39A, member RAS oncogene family) and RAB39B (RAB39B, member RAS oncogene family).Paper_evidenceWBPaper00065943
Curator_confirmedWBPerson324
WBPerson37462
Inferred_automaticallyThis description was generated automatically by a script based on data from the WS291 version of WormBase
Date_last_updated29 Nov 2023 00:00:00
Disease_infoPotential_modelDOID:0112059Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:16499)
DOID:0111781Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:16499)
Molecular_infoCorresponding_CDSD2013.1
Corresponding_CDS_historyD2013.1:wp74
Corresponding_transcriptD2013.1.1
Other_sequence (25)
Associated_featureWBsf650420
WBsf650421
WBsf223635
Experimental_infoRNAi_resultWBRNAi00101872Inferred_automaticallyRNAi_primary
WBRNAi00107759Inferred_automaticallyRNAi_primary
WBRNAi00091937Inferred_automaticallyRNAi_primary
WBRNAi00012560Inferred_automaticallyRNAi_primary
WBRNAi00030377Inferred_automaticallyRNAi_primary
WBRNAi00112237Inferred_automaticallyRNAi_primary
WBRNAi00107758Inferred_automaticallyRNAi_primary
WBRNAi00043437Inferred_automaticallyRNAi_primary
WBRNAi00101873Inferred_automaticallyRNAi_primary
Expr_patternExpr11318
Expr1021236
Expr1032121
Expr1147433
Expr2015226
Expr2033460
Drives_constructWBCnstr00018768
WBCnstr00035586
Construct_productWBCnstr00035586
Microarray_results (18)
Expression_cluster (95)
Interaction (23)
Map_info (3)
ReferenceWBPaper00029101
WBPaper00030935
WBPaper00038491
WBPaper00041898
WBPaper00055090
WBPaper00058949
RemarkMap position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.CGC_data_submission
MethodGene