WormBase Tree Display for Gene: WBGene00004209

WBGene00004209 Evidence: CGC_data_submission
  SMap: S_parent: Sequence: F21H12
  Identity: Version: 2
    Name: CGC_name: ptc-2 Person_evidence: WBPerson349
      Sequence_name: F21H12.4
      Molecular_name: F21H12.4
      Other_name: CELE_F21H12.4 Accession_evidence: NDB BX284602
      Public_name: ptc-2
    DB_info: Database: AceView gene 2G374
        WormQTL gene WBGene00004209
        WormFlux gene WBGene00004209
        NDB locus_tag CELE_F21H12.4
        NCBI gene 191745
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:34 WBPerson1971 Event: Imported: Initial conversion from geneace
        2 21 Oct 2019 15:23:49 WBPerson4025 Event: Changed_class: CDS Pseudogene
    Status: Live
  Gene_info: Biotype: SO:0000336
    Gene_class: ptc
    Allele (44)
    Strain: WBStrain00037349
    RNASeq_FPKM (74)
    Ortholog: WBGene00026178 Caenorhabditis briggsae From_analysis: OrthoMCL
      WBGene00038774 Caenorhabditis briggsae From_analysis: OrthoMCL
      WBGene00157208 Caenorhabditis brenneri From_analysis: TreeFam
      WBGene00121735 Caenorhabditis japonica From_analysis: TreeFam
      WBGene00053202 Caenorhabditis remanei From_analysis: TreeFam
    Paralog: WBGene00004208 Caenorhabditis elegans From_analysis: Panther
      WBGene00004210 Caenorhabditis elegans From_analysis: TreeFam
            Panther
    Structured_description: Concise_description: ptc-2 encodes an ortholog of Drosophila PATCHED (PTC) and human PTCH(OMIM:601309, mutated in basal cell nevus syndrome), which defines oneof seven paralogous families of sterol sensing domain (SSD) proteins;PTC-2 is required for normal fat storage; PTC-2 is also required fornormal egg osmotic integrity, locomotion, egg laying, and viability inmass RNAi assays. Paper_evidence: WBPaper00004265
            WBPaper00005654
            WBPaper00005655
            WBPaper00006395
            WBPaper00025054
            WBPaper00026841
            WBPaper00027263
          Curator_confirmed: WBPerson567
          Date_last_updated: 08 Nov 2006 00:00:00
      Automated_description: Enriched in several structures, including coelomocyte; germ line; germline precursor cell; rectal epithelial cell; and sensory neurons based on tiling array; RNA-seq; and single-cell RNA-seq studies. Is affected by several genes including daf-16; daf-2; and dpy-10 based on microarray and RNA-seq studies. Is affected by paraquat and Sirolimus based on microarray studies. Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Molecular_info: Corresponding_CDS_history: F21H12.4:wp125
      F21H12.4:wp274
    Corresponding_pseudogene: F21H12.4
    Other_sequence: FC810025.1
    Associated_feature: WBsf988053
  Experimental_info: Expr_pattern: Expr1026086
      Expr1032066
      Expr1149177
      Expr2015144
      Expr2033382
    Drives_construct: WBCnstr00035635
    Construct_product: WBCnstr00035635
    Microarray_results (18)
    Expression_cluster (78)
    Interaction (29)
  Map_info: Map: II Position: -0.548008 Error: 0.009907
    Positive: Positive_clone: F21H12 Inferred_automatically: From sequence, transcript, pseudogene data
    Pseudo_map_position
  Reference: WBPaper00004265
    WBPaper00011630
    WBPaper00011803
    WBPaper00022467
    WBPaper00023346
    WBPaper00027263
    WBPaper00038491
    WBPaper00055090
    WBPaper00055674
    WBPaper00064105
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene