WormBase Tree Display for Gene: WBGene00004109
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| WBGene00004109 | SMap | S_parent | Sequence | C34G6 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 2 | |||||||
| Name | CGC_name | stam-1 | Person_evidence | WBPerson44 | |||||
| Sequence_name | C34G6.7 | ||||||||
| Molecular_name | C34G6.7a | ||||||||
| C34G6.7a.1 | |||||||||
| CE29700 | |||||||||
| C34G6.7b | |||||||||
| CE32816 | |||||||||
| C34G6.7a.2 | |||||||||
| C34G6.7b.1 | |||||||||
| Other_name | pqn-19 | ||||||||
| CELE_C34G6.7 | Accession_evidence | NDB | BX284601 | ||||||
| Public_name | stam-1 | ||||||||
| DB_info | Database (11) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:34 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| 2 | 27 Mar 2008 14:42:59 | WBPerson2970 | Name_change | CGC_name | stam-1 | ||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | stam | ||||||||
| Allele (37) | |||||||||
| Strain | WBStrain00031413 | ||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (25) | |||||||||
| Ortholog (41) | |||||||||
| Paralog | WBGene00000166 | Caenorhabditis elegans | From_analysis | WormBase-Compara | |||||
| WBGene00004101 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| WBGene00008402 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| WBGene00015561 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| Structured_description | Concise_description | stam-1 encodes a protein containing an N-terminal VSH domain, a central ubiquitin-interacting motif and SH3 domain, and a C-terminal glutamine/asparagine (Q/N)-rich domain that is the C. elegans ortholog of the Janus kinase substrate STAM ('signal-transducing adaptor molecule'); stam-1 is required for maintaining meiotic arrest and for acetylcholine neurotransmission; STAM-1 is required in the germline for arrested oocytes to continue responding to an inhibitory signal from somatic gonadal sheath cells, before the oocytes have been induced by major sperm protein (MSP) to exit meiotic prophase; STAM-1 is located in puncta of the DA motor neurons; STAM-1 and HGRS-1 physically interact in vivo, forming the C. elegans ESCRT-0 complex on early endosomes; in the context of the complex, both STAM-1 and HGRS-1 bind ubiquitin. | Paper_evidence | WBPaper00005068 | |||||
| WBPaper00012788 | |||||||||
| WBPaper00012830 | |||||||||
| WBPaper00012882 | |||||||||
| WBPaper00012897 | |||||||||
| WBPaper00013003 | |||||||||
| WBPaper00026667 | |||||||||
| WBPaper00027739 | |||||||||
| WBPaper00040092 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| WBPerson567 | |||||||||
| Date_last_updated | 26 Aug 2011 00:00:00 | ||||||||
| Automated_description | Enables ubiquitin binding activity. Involved in several processes, including cellular localization; ephrin receptor signaling pathway; and response to hermaphrodite contact. Located in cilium and early endosome. Part of ESCRT-0 complex. Expressed in CEM; male gonad; neurons; and pharyngeal-intestinal valve. Used to study polycystic kidney disease. Is an ortholog of human STAM (signal transducing adaptor molecule). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Experimental_model | DOID:0080322 | Homo sapiens | Paper_evidence | WBPaper00030801 | ||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 13 Mar 2023 00:00:00 | ||||||||
| Disease_relevance | STAM-1 is orthologous to human STAM (OMIM:601899) and STAM2 (OMIM:606244). | Homo sapiens | Curator_confirmed | WBPerson324 | |||||
| Date_last_updated | 26 Aug 2011 00:00:00 | ||||||||
| Models_disease_asserted | WBDOannot00000002 | ||||||||
| Molecular_info | Corresponding_CDS | C34G6.7a | |||||||
| C34G6.7b | |||||||||
| Corresponding_transcript | C34G6.7a.1 | ||||||||
| C34G6.7a.2 | |||||||||
| C34G6.7b.1 | |||||||||
| Other_sequence (51) | |||||||||
| Associated_feature | WBsf649201 | ||||||||
| WBsf649202 | |||||||||
| WBsf983796 | |||||||||
| WBsf1009880 | |||||||||
| WBsf219506 | |||||||||
| WBsf219507 | |||||||||
| Experimental_info | RNAi_result (14) | ||||||||
| Expr_pattern | Expr3570 | ||||||||
| Expr8036 | |||||||||
| Expr8037 | |||||||||
| Expr16172 | |||||||||
| Expr1028135 | |||||||||
| Expr1031987 | |||||||||
| Expr1145940 | |||||||||
| Expr2016953 | |||||||||
| Expr2035101 | |||||||||
| Drives_construct | WBCnstr00013070 | ||||||||
| WBCnstr00014870 | |||||||||
| WBCnstr00037940 | |||||||||
| Construct_product | WBCnstr00011494 | ||||||||
| WBCnstr00013071 | |||||||||
| WBCnstr00014870 | |||||||||
| WBCnstr00014871 | |||||||||
| WBCnstr00014872 | |||||||||
| WBCnstr00037940 | |||||||||
| Antibody | WBAntibody00002291 | ||||||||
| Microarray_results (32) | |||||||||
| Expression_cluster (104) | |||||||||
| Interaction (86) | |||||||||
| WBProcess | WBbiopr:00000012 | ||||||||
| WBbiopr:00000120 | |||||||||
| Map_info | Map | I | Position | 0.478484 | Error | 0.001037 | |||
| Positive | Positive_clone | C34G6 | Inferred_automatically | From CDS info | |||||
| From sequence, transcript, pseudogene data | |||||||||
| Mapping_data | Multi_point | 4601 | |||||||
| 5068 | |||||||||
| Pseudo_map_position | |||||||||
| Reference (11) | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
