WormBase Tree Display for Gene: WBGene00004077
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WBGene00004077 | Evidence | CGC_data_submission | |||||
---|---|---|---|---|---|---|---|
SMap | S_parent | Sequence | CHROMOSOME_I | ||||
Identity (6) | |||||||
Gene_info | Biotype | SO:0001217 | |||||
Gene_class | pop | ||||||
Allele (168) | |||||||
Legacy_information | [Lin R] Pop (posterior pharynx defective) phenotype: maternal lethal, causing MS blastomere to adopt the fate of sister blastomere E; resulting embryos have twice the wildtype amount of gut. zu189 isolated in mutator background, probable Tc1 insertion. | ||||||
[C.elegansII] zu189mut : maternal effect embryonic lethal,no MS-derived pharyngeal cells; MS blastomere adopts the fate of sister blastomere E; resulting embryos have twice the wildtype amount of gut. NA1. Cloned: encodes predicted 487 aa protein with HMG box; antibody stains nuclei of oocytes, early blastomeres. [Lin et al. 1995; JJ] | |||||||
Strain (11) | |||||||
RNASeq_FPKM (74) | |||||||
GO_annotation (113) | |||||||
Ortholog (59) | |||||||
Structured_description | Concise_description | pop-1 encodes an HMG box-containing protein that is the sole C. elegans member of the TCF/LEF family of transcription factors; in C. elegans, POP-1 functions as a component of the canonical and noncanonical Wnt signaling pathways that are required for cell migrations and binary cell fate decisions associated with asymmetric cell division, respectively; in yeast two-hybrid assays, the POP-1 N-terminal beta-catenin binding domain interacts with BAR-1/beta-catenin as well as with the more divergent beta-catenin, SYS-1; when coexpressed with SYS-1, POP-1 is able to activate transcription from a promoter with TCF binding sites; during development, maternally provided POP-1 is first detected in the nuclei of maturing oocytes and then in nearly all cells of the early embryo; in sister blastomeres in the early embryo, POP-1 is detected at lower levels in posterior blastomeres, such as E and P3, than in corresponding anterior blastomeres, MS and C; in later developmental stages, POP-1 is detected in a subset of tissues including hypodermal seam cells, gonadal precursors, and the developing vulva; in the vulva, POP-1 also exhibits an asymmetric staining pattern, with sister cells showing high or low levels of POP-1 depending upon their orientation along the anterior/posterior axis of the vulva. | Paper_evidence | WBPaper00002330 | |||
WBPaper00004103 | |||||||
WBPaper00005116 | |||||||
WBPaper00024693 | |||||||
WBPaper00026603 | |||||||
Curator_confirmed | WBPerson1843 | ||||||
WBPerson567 | |||||||
Date_last_updated | 04 Aug 2005 00:00:00 | ||||||
Automated_description | Enables several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; beta-catenin binding activity; and enzyme binding activity. Involved in several processes, including mesodermal cell fate commitment; regulation of cell division; and regulation of gene expression. Located in cytoplasm and nucleus. Expressed in several structures, including ABplpapaaa; ABprpapaaa; oocyte; somatic nervous system; and vulva. Used to study obesity. Human ortholog(s) of this gene implicated in several diseases, including diabetes mellitus (multiple); endocrine gland cancer (multiple); and prostate disease (multiple). Is an ortholog of human TCF7L2 (transcription factor 7 like 2). | Paper_evidence | WBPaper00065943 | ||||
Curator_confirmed | WBPerson324 | ||||||
WBPerson37462 | |||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||
Disease_info | Experimental_model | DOID:9970 | Homo sapiens | Paper_evidence | WBPaper00061889 | ||
Curator_confirmed | WBPerson324 | ||||||
Date_last_updated | 28 Jun 2022 00:00:00 | ||||||
Potential_model | DOID:9351 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:11641) | |||
DOID:9256 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:11641) | ||||
DOID:9352 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:11641) | ||||
DOID:11714 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:11641) | ||||
DOID:2394 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:6551) | ||||
DOID:3969 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:6551) | ||||
DOID:8634 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:6551) | ||||
DOID:10283 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:11639,HGNC:11641,HGNC:6551) | ||||
DOID:1793 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:11641) | ||||
DOID:1612 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:11641) | ||||
Models_disease_in_annotation | WBDOannot00001266 | ||||||
Molecular_info | Corresponding_CDS | W10C8.2 | |||||
Corresponding_CDS_history | W10C8.2:wp229 | ||||||
Corresponding_transcript | W10C8.2.1 | ||||||
Other_sequence (26) | |||||||
Associated_feature (14) | |||||||
Gene_product_binds (20) | |||||||
Transcription_factor | WBTranscriptionFactor000102 | ||||||
Experimental_info | RNAi_result (249) | ||||||
Expr_pattern (15) | |||||||
Drives_construct (3) | |||||||
Construct_product (13) | |||||||
Antibody | WBAntibody00000100 | ||||||
WBAntibody00000162 | |||||||
WBAntibody00000612 | |||||||
WBAntibody00000723 | |||||||
WBAntibody00000724 | |||||||
Microarray_results (22) | |||||||
Expression_cluster (116) | |||||||
Interaction (464) | |||||||
Anatomy_function | WBbtf0106 | ||||||
WBProcess (3) | |||||||
Map_info | Map | I | Position | -5.32204 | Error | 0.039261 | |
Well_ordered | |||||||
Positive | Positive_clone | BF8 | |||||
W10C8 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
Negative | Negative_clone | K11A2 | |||||
Mapping_data | 2_point | 7005 | |||||
7006 | |||||||
Multi_point | 3030 | ||||||
4915 | |||||||
5051 | |||||||
Pos_neg_data | 8160 | ||||||
8161 | |||||||
8162 | |||||||
8163 | |||||||
8164 | |||||||
8165 | |||||||
10668 | |||||||
10669 | |||||||
Reference (328) | |||||||
Picture | WBPicture0000013083 | ||||||
WBPicture0000013084 | |||||||
Remark | Datum extracted from Lin et al. (1995). | ||||||
[Lin R] zu189 is Tc1 insertion allele, Tc1 mapped to BF8 + | |||||||
Sequence connection from [Lin R, Thompson S, Priess JR], [krb 020702] | |||||||
old_name sys-2 becomes new_name pop-1 from [Kimble JE]. | |||||||
Method | Gene |