WormBase Tree Display for Gene: WBGene00004049
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WBGene00004049 | SMap | S_parent | Sequence | Y71F9AL | |||
---|---|---|---|---|---|---|---|
Identity | Version | 2 | |||||
Name | CGC_name | parp-1 | Person_evidence | WBPerson236 | |||
Sequence_name | Y71F9AL.18 | ||||||
Molecular_name (13) | |||||||
Other_name | pme-1 | ||||||
CELE_Y71F9AL.18 | Accession_evidence | NDB | BX284601 | ||||
Public_name | parp-1 | ||||||
DB_info | Database (12) | ||||||
Species | Caenorhabditis elegans | ||||||
History | Version_change (2) | ||||||
Status | Live | ||||||
Gene_info | Biotype | SO:0001217 | |||||
Gene_class | parp | ||||||
Allele (323) | |||||||
Strain | WBStrain00031749 | ||||||
RNASeq_FPKM (74) | |||||||
GO_annotation (24) | |||||||
Ortholog (66) | |||||||
Paralog (4) | |||||||
Structured_description | Concise_description | parp-1 (formerly known as pme-1) encodes a poly(ADP-ribose) polymerase (PARP) orthologous to human PARP1 (OMIM:173870); PARP-1 has two N-terminal zinc fingers that probably bind DNA, and a C-terminal catalytic domain; PARP-1 exhibits poly(ADP-ribose) activity in vitro, which is blocked by mammalian PARP inhibitors; since these inhibitors also cause embryonic lethality in worms exposed to ionizing radiation, PARP-1 is likely to be required in vivo for repairing broken DNA. | Paper_evidence | WBPaper00005600 | |||
WBPaper00025222 | |||||||
Curator_confirmed | WBPerson1843 | ||||||
WBPerson567 | |||||||
Date_last_updated | 14 Nov 2014 00:00:00 | ||||||
Automated_description | Enables NAD+ ADP-ribosyltransferase activity. Involved in determination of adult lifespan. Predicted to be located in nucleolus. Used to study type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease; idiopathic pulmonary fibrosis; and perinatal necrotizing enterocolitis. Is an ortholog of human PARP1 (poly(ADP-ribose) polymerase 1). | Paper_evidence | WBPaper00065943 | ||||
Curator_confirmed | WBPerson324 | ||||||
WBPerson37462 | |||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||
Disease_info | Experimental_model | DOID:9352 | Homo sapiens | Paper_evidence | WBPaper00053647 | ||
Curator_confirmed | WBPerson324 | ||||||
Date_last_updated | 04 Mar 2019 00:00:00 | ||||||
Potential_model (14) | |||||||
Models_disease_asserted | WBDOannot00000650 | ||||||
Molecular_info | Corresponding_CDS | Y71F9AL.18a | |||||
Y71F9AL.18b | |||||||
Y71F9AL.18c | |||||||
Y71F9AL.18d | |||||||
Corresponding_transcript | Y71F9AL.18a.1 | ||||||
Y71F9AL.18a.2 | |||||||
Y71F9AL.18b.1 | |||||||
Y71F9AL.18c.1 | |||||||
Y71F9AL.18d.1 | |||||||
Other_sequence (12) | |||||||
Associated_feature | WBsf976649 | ||||||
WBsf976650 | |||||||
WBsf983015 | |||||||
WBsf983016 | |||||||
WBsf1009424 | |||||||
WBsf219077 | |||||||
WBsf219078 | |||||||
Experimental_info | RNAi_result (11) | ||||||
Expr_pattern | Expr2249 | ||||||
Expr1023238 | |||||||
Expr1031949 | |||||||
Expr1161576 | |||||||
Expr2014736 | |||||||
Expr2032970 | |||||||
Microarray_results (27) | |||||||
Expression_cluster (142) | |||||||
Interaction (59) | |||||||
Map_info | Map | I | Position | -5.30235 | Error | 0.001434 | |
Positive | Positive_clone | Y71F9AL | Inferred_automatically | From CDS info | |||
From sequence, transcript, pseudogene data | |||||||
Mapping_data | Multi_point | 4775 | |||||
5051 | |||||||
Pseudo_map_position | |||||||
Reference (24) | |||||||
Remark | Gene information and sequence connection from Serge Desnoyers. krb [020430] | ||||||
Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | ||||||
Method | Gene |