WormBase Tree Display for Gene: WBGene00004006
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| WBGene00004006 | SMap | S_parent | Sequence | F22E10 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | pgp-12 | Person_evidence | WBPerson490 | |||||
| Sequence_name | F22E10.1 | ||||||||
| Molecular_name | F22E10.1 | ||||||||
| F22E10.1.1 | |||||||||
| CE03260 | |||||||||
| Other_name | CELE_F22E10.1 | Accession_evidence | NDB | BX284606 | |||||
| Public_name | pgp-12 | ||||||||
| DB_info | Database | AceView | gene | XN355 | |||||
| WormQTL | gene | WBGene00004006 | |||||||
| WormFlux | gene | WBGene00004006 | |||||||
| NDB | locus_tag | CELE_F22E10.1 | |||||||
| Panther | gene | CAEEL|WormBase=WBGene00004006|UniProtKB=Q19733 | |||||||
| family | PTHR24221 | ||||||||
| NCBI | gene | 181415 | |||||||
| RefSeq | protein | NM_077725.6 | |||||||
| TrEMBL | UniProtAcc | Q19733 | |||||||
| UniProt_GCRP | UniProtAcc | Q19733 | |||||||
| OMIM | gene | 171050 | |||||||
| 171060 | |||||||||
| 603201 | |||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:33 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | pgp | ||||||||
| Allele (92) | |||||||||
| Strain | WBStrain00001161 | ||||||||
| WBStrain00001227 | |||||||||
| WBStrain00035488 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (13) | |||||||||
| Ortholog (48) | |||||||||
| Paralog (23) | |||||||||
| Structured_description | Concise_description | pgp-12 encodes a transmembrane protein that is a member of the P-glycoprotein subclass of ATP-binding cassette (ABC) transporters; pgp-12 promoter fusion constructs reveal expression in the excretory cell, consistent with a role for pgp-12 in metabolite transporter activity; pgp-12 expression is regulated by the DCP-66 transcription factor which binds the pgp-12 Ex-1 promoter element in yeast one-hybrid and EMSA experiments. | Paper_evidence | WBPaper00026805 | |||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 03 Jan 2012 00:00:00 | ||||||||
| Automated_description | Predicted to enable ATPase-coupled transmembrane transporter activity. Involved in response to nematicide. Predicted to be located in membrane. Expressed in head and tail. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); carcinoma (multiple); and intrahepatic cholestasis (multiple). Is an ortholog of several human genes including ABCB1 (ATP binding cassette subfamily B member 1); ABCB11 (ATP binding cassette subfamily B member 11); and ABCB4 (ATP binding cassette subfamily B member 4). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model (41) | ||||||||
| Molecular_info | Corresponding_CDS | F22E10.1 | |||||||
| Corresponding_transcript | F22E10.1.1 | ||||||||
| Other_sequence | HM635767.1 | ||||||||
| Dviv_isotig15817 | |||||||||
| Dviv_isotig15816 | |||||||||
| PT02059 | |||||||||
| Associated_feature | WBsf1007410 | ||||||||
| WBsf1024118 | |||||||||
| WBsf236506 | |||||||||
| WBsf236507 | |||||||||
| WBsf236508 | |||||||||
| Experimental_info | RNAi_result | WBRNAi00013751 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00066529 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00045322 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern (15) | |||||||||
| Drives_construct (14) | |||||||||
| Construct_product | WBCnstr00035745 | ||||||||
| Microarray_results (20) | |||||||||
| Expression_cluster (136) | |||||||||
| Interaction (23) | |||||||||
| Map_info | Map | X | Position | 8.15136 | Error | 0.016185 | |||
| Positive | Positive_clone | F22E10 | Inferred_automatically | From CDS info | |||||
| From sequence, transcript, pseudogene data | |||||||||
| Mapping_data | Multi_point | 4581 | |||||||
| 4582 | |||||||||
| 4634 | |||||||||
| Pseudo_map_position | |||||||||
| Reference (15) | |||||||||
| Remark | Sequence connection from [Sheps JA, Baillie DL] [040902 ck1] | ||||||||
| Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | ||||||||
| Method | Gene |
