WormBase Tree Display for Gene: WBGene00003992
expand all nodes | collapse all nodes | view schema
WBGene00003992 | SMap | S_parent | Sequence | ZK381 | |||
---|---|---|---|---|---|---|---|
Identity (6) | |||||||
Gene_info | Biotype | SO:0001217 | |||||
Gene_class | pgl | ||||||
Allele (59) | |||||||
Legacy_information | [C.elegansII] ct131 : germline P granules unstained by some(not all) monoclonal antibodies. 5% sterile, Mes if grown at 26C. Cloned: cosmid rescue (B0318). [SS] | ||||||
P granules are not stained by K76 or OIC1D4, two anti-P-granule monoclonal antibodies. Mutants display sterility that is temperature-sensitive and has both a maternal and a nonmaternal component. | |||||||
Strain (22) | |||||||
RNASeq_FPKM (74) | |||||||
GO_annotation (33) | |||||||
Ortholog (22) | |||||||
Paralog (38) | |||||||
Structured_description | Concise_description | pgl-1 encodes a predicted RNA-binding protein that contains a number of C-terminal RGG box motifs; PGL-1 activity is required at high temperatures during midlarval to adult stages for postembryonic germline development and hence fertility, and also for proper formation of the germline-specific P granules; PGL-1 protein, supplied maternally and embryonically, is a constitutive P granule component and thus, its localization is cytoplasmic in oocytes and early embryos, while perinuclear in the germline blastomere P4 and proliferating germ cells of larvae and adults; pgl-1 mRNA is expressed exclusively in hermaphrodite and male germlines and is detectable at all stages of development, with highest levels seen in adults; PGL-1 localization to P granules requires wild-type activity of the predicted germline helicase GLH-1. | Paper_evidence | WBPaper00003186 | |||
WBPaper00004672 | |||||||
WBPaper00004940 | |||||||
Curator_confirmed | WBPerson1843 | ||||||
WBPerson567 | |||||||
Date_last_updated | 26 Aug 2004 00:00:00 | ||||||
Automated_description | Enables RNA endonuclease activity; identical protein binding activity; and protein self-association. Involved in P granule organization and germ-line stem cell division. Located in P granule. Expressed in germ line. | Paper_evidence | WBPaper00065943 | ||||
Curator_confirmed | WBPerson324 | ||||||
WBPerson37462 | |||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||
Molecular_info | Corresponding_CDS | ZK381.4a | |||||
ZK381.4b | |||||||
Corresponding_CDS_history | ZK381.4:wp150 | ||||||
Corresponding_transcript | ZK381.4a.1 | ||||||
ZK381.4a.2 | |||||||
ZK381.4b.1 | |||||||
Other_sequence | CR03959 | ||||||
CBC03903_1 | |||||||
CRC01255_1 | |||||||
CR03489 | |||||||
JI171371.1 | |||||||
Associated_feature | WBsf977133 | ||||||
WBsf977134 | |||||||
WBsf230205 | |||||||
Experimental_info | RNAi_result | WBRNAi00113912 | Inferred_automatically | RNAi_primary | |||
WBRNAi00021989 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00059393 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00069464 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00007860 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00027792 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00084326 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00084334 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00084341 | Inferred_automatically | RNAi_primary | |||||
Expr_pattern (11) | |||||||
Drives_construct | WBCnstr00035758 | ||||||
Construct_product (25) | |||||||
Regulate_expr_cluster (19) | |||||||
Antibody (25) | |||||||
Microarray_results (24) | |||||||
Expression_cluster (198) | |||||||
Interaction (310) | |||||||
Map_info | Map | IV | Position | 3.25355 | Error | 0.002367 | |
Well_ordered | |||||||
Positive | Inside_rearr | nDf41 | |||||
Positive_clone | B0318 | ||||||
ZK381 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
Negative | Negative_clone | C02F1 | |||||
C25A8 | |||||||
T22D1 | |||||||
Mapping_data (2) | |||||||
Reference (159) | |||||||
Method | Gene |