WormBase Tree Display for Gene: WBGene00003887

WBGene00003887 SMap: S_parent: Sequence: T05D4
  Identity: Version: 2
    Name: CGC_name: osm-7 Person_evidence: WBPerson242
      Sequence_name: T05D4.4
      Molecular_name: T05D4.4a
        T05D4.4a.1
        CE34087
        T05D4.4b
        CE43968
        T05D4.4b.1
      Other_name: CELE_T05D4.4 Accession_evidence: NDB BX284603
      Public_name: osm-7
    DB_info: Database: AceView gene 3O667
        WormQTL gene WBGene00003887
        WormFlux gene WBGene00003887
        NDB locus_tag CELE_T05D4.4
        Panther gene CAEEL|WormBase=WBGene00003887|UniProtKB=O45750
          family PTHR35015
        NCBI gene 176790
        RefSeq protein NM_001268280.3
            NM_001268281.3
        TREEFAM TREEFAM_ID TF315672
        TrEMBL UniProtAcc O45750
            C8JQS1
        UniProt_GCRP UniProtAcc O45750
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:33 WBPerson1971 Event: Imported: Initial conversion from geneace
        2 06 Jul 2007 16:19:40 WBPerson2970 Event: Acquires_merge: WBGene00011477
      Acquires_merge: WBGene00011477
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: osm
    Allele (80)
    Legacy_information: [C.elegansII] n1515 : defective osmotic avoidance; defective chemotaxis; slow pharyngeal pumping; FITC uptake normal. NA1. [CX; MT; JT]
    Strain: WBStrain00027073
      WBStrain00008300
    RNASeq_FPKM (74)
    GO_annotation: 00007066
      00007067
      00007068
      00007069
      00035148
    Ortholog (29)
    Paralog: WBGene00003891 Caenorhabditis elegans From_analysis: Panther
      WBGene00013980 Caenorhabditis elegans From_analysis: Panther
      WBGene00019331 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00019640 Caenorhabditis elegans From_analysis: WormBase-Compara
    Structured_description: Concise_description: osm-7 encodes a protein required for normal osmosensation, osmotic resistance, and defecation rhythm, and for fully normal growth rate; OSM-7 has no clear orthologs outside of nematodes, but is paralogous to DOS-1, OSM-11, and K02F3.7; OSM-7 is expressed in the hypodermis, has a predicted signal sequence with 12 conserved cysteine residues, and may be secreted; osm-7 mutants have abnormally high levels of internal glycerol, defective osmotic avoidance, and slowed defecation rhythms characteristic of worms under chronic osmotic stress; osm-7 mutants are also also somewhat scrawny and slow-growing; osm-7(RNAi) animals show constitutive gpdh-1 transcription. Paper_evidence: WBPaper00028383
            WBPaper00028499
          Curator_confirmed: WBPerson567
          Date_last_updated: 29 Mar 2008 00:00:00
      Automated_description: Predicted to enable Notch binding activity. Involved in regulation of gene expression and response to osmotic stress. Predicted to be located in extracellular space. Expressed in hypodermis. Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Molecular_info: Corresponding_CDS: T05D4.4a
      T05D4.4b
    Corresponding_CDS_history: T05D4.4:wp101
    Corresponding_transcript: T05D4.4a.1
      T05D4.4b.1
    Other_sequence (11)
    Associated_feature: WBsf994924
      WBsf994925
      WBsf994926
      WBsf994927
      WBsf1016391
      WBsf226034
  Experimental_info: RNAi_result: WBRNAi00106881 Inferred_automatically: RNAi_primary
      WBRNAi00009116 Inferred_automatically: RNAi_primary
      WBRNAi00097001 Inferred_automatically: RNAi_primary
      WBRNAi00064429 Inferred_automatically: RNAi_primary
      WBRNAi00035199 Inferred_automatically: RNAi_primary
      WBRNAi00000259 Inferred_automatically: RNAi_primary
      WBRNAi00006304 Inferred_automatically: RNAi_primary
      WBRNAi00026192 Inferred_automatically: RNAi_primary
      WBRNAi00088842 Inferred_automatically: RNAi_primary
      WBRNAi00052507 Inferred_automatically: RNAi_primary
    Expr_pattern: Expr8274
      Expr1021517
      Expr1031830
      Expr1156132
      Expr2014646
      Expr2032879
    Drives_construct: WBCnstr00013230
      WBCnstr00035813
    Construct_product: WBCnstr00013230
      WBCnstr00035813
    Regulate_expr_cluster: WBPaper00035873:osm-7_regulated
    Microarray_results (21)
    Expression_cluster (190)
    Interaction: WBInteraction000454075
      WBInteraction000500645
      WBInteraction000500656
      WBInteraction000500658
      WBInteraction000500659
      WBInteraction000500660
      WBInteraction000502515
      WBInteraction000576631
  Map_info: Map: III Position: 21.2743
    Positive: Positive_clone: T05D4 Inferred_automatically: From sequence, transcript, pseudogene data
    Mapping_data: 2_point: 3717
        3718
      Multi_point: 1362
      Pos_neg_data: 10947
        10948
  Reference (28)
  Method: Gene