WormBase Tree Display for Gene: WBGene00003885
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WBGene00003885 | Evidence | CGC_data_submission | |||||
---|---|---|---|---|---|---|---|
SMap | S_parent | Sequence | Y41G9A | ||||
Identity (6) | |||||||
Gene_info (11) | |||||||
Disease_info | Experimental_model | DOID:898 | Homo sapiens | Paper_evidence | WBPaper00004603 | ||
WBPaper00004715 | |||||||
Accession_evidence | OMIM | 173900 | |||||
Curator_confirmed | WBPerson324 | ||||||
Date_last_updated | 30 Apr 2018 00:00:00 | ||||||
Disease_relevance | Studies in the worm C. elegans have contributed extensively to the finding that cystic kidney diseases can be considered ciliopathies; osm-5 is orthologous to the murine polycystic kidney disease gene Tg737, which encodes the protein Polaris and human IFT88; both polaris and OSM-5 have the tetratricopeptide repeat (TPT), a motif that mediates protein-protein interactions; the association of pathologies in mice mutant for Tg737 with ciliary defects in the kidney cells and studies in elegans that demonstrate that osm-5 is expressed and migrates within cilia, substantiate a ciliogenic role for polaris and osm-5, possibly as components of the intraflagellar transport (IFT) system; osm-5 is also required for correct ciliary targeting of lov-1 and pkd-2, genes that are orthologous to human PKD1 and PKD2, which are mutated in human autosomal dominant polycystic kidney disease. | Homo sapiens | Paper_evidence | WBPaper00004603 | |||
Curator_confirmed | WBPerson324 | ||||||
Date_last_updated | 31 Jan 2013 00:00:00 | ||||||
Models_disease_in_annotation | WBDOannot00000030 | ||||||
Models_disease_asserted | WBDOannot00000513 | ||||||
Molecular_info | Corresponding_CDS | Y41G9A.1 | |||||
Corresponding_transcript | Y41G9A.1.1 | ||||||
Other_sequence (25) | |||||||
Associated_feature (12) | |||||||
Experimental_info | RNAi_result | WBRNAi00095205 | Inferred_automatically | RNAi_primary | |||
WBRNAi00056418 | Inferred_automatically | RNAi_primary | |||||
Expr_pattern (13) | |||||||
Drives_construct (12) | |||||||
Construct_product | WBCnstr00006237 | ||||||
WBCnstr00008467 | |||||||
WBCnstr00009069 | |||||||
WBCnstr00010229 | |||||||
WBCnstr00013368 | |||||||
WBCnstr00039933 | |||||||
Antibody | WBAntibody00000351 | ||||||
WBAntibody00001248 | |||||||
Microarray_results (19) | |||||||
Expression_cluster (200) | |||||||
Interaction (43) | |||||||
WBProcess | WBbiopr:00000001 | ||||||
WBbiopr:00000012 | |||||||
Map_info | Map | X | Position | -12.6622 | Error | 0.00141 | |
Well_ordered | |||||||
Positive | Positive_clone | Y41G9A | Inferred_automatically | From sequence, transcript, pseudogene data | |||
Mapping_data | 2_point | 376 | |||||
377 | |||||||
3384 | |||||||
Multi_point | 1209 | ||||||
1210 | |||||||
1211 | |||||||
1212 | |||||||
5291 | |||||||
5597 | |||||||
Pos_neg_data | 3180 | ||||||
5450 | |||||||
Reference (105) | |||||||
Remark | Sequence connection from [Haycroft CG, Thomas JH] | ||||||
Data extracted from Haycraft et al (2001) | |||||||
Method | Gene |