WormBase Tree Display for Gene: WBGene00003553
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WBGene00003553 | Evidence | Author_evidence | Moehrlen F | ||||
---|---|---|---|---|---|---|---|
SMap | S_parent | Sequence | C17G1 | ||||
Identity (6) | |||||||
Gene_info | Biotype | SO:0001217 | |||||
Gene_class | nas | ||||||
Allele (69) | |||||||
Strain | WBStrain00002602 | ||||||
WBStrain00037444 | |||||||
WBStrain00006660 | |||||||
WBStrain00006680 | |||||||
RNASeq_FPKM (74) | |||||||
GO_annotation (18) | |||||||
Ortholog (31) | |||||||
Paralog (48) | |||||||
Structured_description | Concise_description | nas-37 encodes a Astacin-class metalloprotease required for full ecdysisthat is expressed in hypodermal cells 4 hours before each ecdysis; NAS-37protein has an N-terminal signal sequence followed by an Astacin proteasedomain and three protein-binding domains (EGF-like, CUB, andthrombospondin); NAS-37 accumulates in anterior cuticle, being shed withit after ecdysis; nas-37 mutants fail to complete anterior ecdysis at eachmolt; nas-37(ox196) mutations alter an evolutionarily invariant histidineresidue yet are phenotypically indistinguishable from null mutations,consistent with the hypothesis that NAS-37 encodes a functional protease;NAS-37 orthologs are found in other nematodes such as Brugia malayi. | Paper_evidence | WBPaper00024579 | |||
Curator_confirmed | WBPerson1843 | ||||||
WBPerson567 | |||||||
Date_last_updated | 16 Dec 2010 00:00:00 | ||||||
Automated_description | Enables metalloendopeptidase activity. Involved in collagen and cuticulin-based cuticle development and ecdysis, collagen and cuticulin-based cuticle. Located in extracellular region. Expressed in cuticle; epithelial cell; intestine; and rectal gland cell. | Paper_evidence | WBPaper00065943 | ||||
Curator_confirmed | WBPerson324 | ||||||
WBPerson37462 | |||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||
Molecular_info | Corresponding_CDS | C17G1.6a | |||||
C17G1.6b | |||||||
Corresponding_CDS_history | C17G1.6:wp83 | ||||||
Corresponding_transcript | C17G1.6a.1 | ||||||
C17G1.6b.1 | |||||||
Other_sequence (12) | |||||||
Associated_feature | WBsf1006575 | ||||||
WBsf1006576 | |||||||
WBsf1006577 | |||||||
WBsf1023644 | |||||||
WBsf237814 | |||||||
Experimental_info | RNAi_result (11) | ||||||
Expr_pattern (11) | |||||||
Drives_construct (11) | |||||||
Construct_product | WBCnstr00006847 | ||||||
WBCnstr00011093 | |||||||
WBCnstr00011155 | |||||||
WBCnstr00013626 | |||||||
WBCnstr00036048 | |||||||
Microarray_results (22) | |||||||
Expression_cluster (174) | |||||||
Interaction (15) | |||||||
Map_info | Map | X | Position | 1.73123 | Error | 0.000121 | |
Positive | Positive_clone | C17G1 | Inferred_automatically | From CDS info | |||
From sequence, transcript, pseudogene data | |||||||
Mapping_data | Multi_point | 5083 | |||||
Pseudo_map_position | |||||||
Reference (18) | |||||||
Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||
Method | Gene |