WormBase Tree Display for Gene: WBGene00003386
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WBGene00003386 | Evidence | Paper_evidence | WBPaper00004415 | ||||||
---|---|---|---|---|---|---|---|---|---|
SMap | S_parent | Sequence | K06C4 | ||||||
Identity | Version | 1 | |||||||
Name | CGC_name | mod-1 | Person_evidence | WBPerson268 | |||||
Sequence_name | K06C4.6 | ||||||||
Molecular_name | K06C4.6a | ||||||||
K06C4.6a.1 | |||||||||
CE28590 | |||||||||
K06C4.6b | |||||||||
CE30814 | |||||||||
K06C4.6c | |||||||||
CE38391 | |||||||||
K06C4.6b.1 | |||||||||
K06C4.6c.1 | |||||||||
Other_name | CELE_K06C4.6 | Accession_evidence | NDB | BX284605 | |||||
Public_name | mod-1 | ||||||||
DB_info | Database | AceView | gene | 5J390 | |||||
WormQTL | gene | WBGene00003386 | |||||||
WormFlux | gene | WBGene00003386 | |||||||
NDB | locus_tag | CELE_K06C4.6 | |||||||
Panther | gene | CAEEL|WormBase=WBGene00003386|UniProtKB=Q9GQ00 | |||||||
family | PTHR18945 | ||||||||
NCBI | gene | 179269 | |||||||
RefSeq | protein | NM_001028863.5 | |||||||
NM_171495.6 | |||||||||
NM_001028864.4 | |||||||||
SwissProt | UniProtAcc | Q9GQ00 | |||||||
TREEFAM | TREEFAM_ID | TF315490 | |||||||
UniProt_GCRP | UniProtAcc | Q9GQ00 | |||||||
Species | Caenorhabditis elegans | ||||||||
History | Version_change | 1 | 07 Apr 2004 11:29:31 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
Status | Live | ||||||||
Gene_info | Biotype | SO:0001217 | |||||||
Gene_class | mod | ||||||||
Allele (72) | |||||||||
Legacy_information | [Ranganathan R] modulation of locomotion defective. Resistant to effects of serotonin on locomotion. | ||||||||
Strain | WBStrain00027365 | ||||||||
WBStrain00055584 | |||||||||
WBStrain00055581 | |||||||||
WBStrain00055576 | |||||||||
WBStrain00055575 | |||||||||
WBStrain00055061 | |||||||||
WBStrain00055570 | |||||||||
WBStrain00055580 | |||||||||
WBStrain00055579 | |||||||||
RNASeq_FPKM (74) | |||||||||
GO_annotation (37) | |||||||||
Ortholog (29) | |||||||||
Paralog (100) | |||||||||
Structured_description | Concise_description | mod-1 encodes a serotonin-gated chloride channel; contrary to published literature, MOD-1 activity is NOT required for the enhanced slowing response exhibited by food-deprived animals upon encountering a bacterial food source; subsequent studies have shown that mod-1 mutants (n3034, ok103, nr2043) do not exhibit reduced enhanced slowing and that the behavioral defect of the original isolate and mod-1 chloride channel mutation (n3034) are genetically separable; when expressed in voltage-clamped Xenopus oocytes, MOD-1 is able to form a serotonin-gated ion channel, and when expressed in human tissue culture cells, MOD-1 exhibits behavior consistent with chloride selectivity; a rescuing MOD-1::GFP construct is expressed in the cell bodies and axons (the latter presumably due to overexpression) of neurons in the head, tail, and ventral nerve cord. | Paper_evidence | WBPaper00004415 | |||||
Person_evidence | WBPerson461 | ||||||||
Curator_confirmed | WBPerson1843 | ||||||||
Date_last_updated | 07 Oct 2009 00:00:00 | ||||||||
Automated_description | Enables serotonin binding activity and serotonin-gated chloride channel activity. Involved in several processes, including behavioral response to starvation; locomotory exploration behavior; and positive regulation of fatty acid beta-oxidation by serotonin receptor signaling pathway. Located in neuronal cell body and plasma membrane. Expressed in body wall musculature and neurons. Used to study cocaine abuse. | Paper_evidence | WBPaper00065943 | ||||||
Curator_confirmed | WBPerson324 | ||||||||
WBPerson37462 | |||||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
Disease_info | Experimental_model | DOID:809 | Homo sapiens | Paper_evidence | WBPaper00034643 | ||||
Curator_confirmed | WBPerson324 | ||||||||
Date_last_updated | 28 May 2019 00:00:00 | ||||||||
Models_disease_asserted | WBDOannot00000683 | ||||||||
Molecular_info | Corresponding_CDS | K06C4.6a | |||||||
K06C4.6b | |||||||||
K06C4.6c | |||||||||
Corresponding_transcript | K06C4.6a.1 | ||||||||
K06C4.6b.1 | |||||||||
K06C4.6c.1 | |||||||||
Other_sequence | JI466929.1 | ||||||||
JI169197.1 | |||||||||
JI478000.1 | |||||||||
JI468889.1 | |||||||||
Associated_feature | WBsf669190 | ||||||||
WBsf1000785 | |||||||||
WBsf1000786 | |||||||||
WBsf1020115 | |||||||||
WBsf1020116 | |||||||||
WBsf234154 | |||||||||
WBsf234155 | |||||||||
WBsf234156 | |||||||||
WBsf234157 | |||||||||
Experimental_info | RNAi_result | WBRNAi00034017 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00050055 | Inferred_automatically | RNAi_primary | |||||||
Expr_pattern (11) | |||||||||
Drives_construct (10) | |||||||||
Construct_product | WBCnstr00007179 | ||||||||
WBCnstr00007180 | |||||||||
WBCnstr00015422 | |||||||||
WBCnstr00020388 | |||||||||
WBCnstr00036146 | |||||||||
Microarray_results (28) | |||||||||
Expression_cluster (131) | |||||||||
Interaction | WBInteraction000001399 | ||||||||
WBInteraction000031265 | |||||||||
WBInteraction000166111 | |||||||||
WBInteraction000520738 | |||||||||
WBInteraction000525285 | |||||||||
Map_info | Map | V | Position | 1.72643 | Error | 0.025158 | |||
Well_ordered | |||||||||
Positive | Positive_clone | C38E12 | |||||||
K06C4 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||||
Negative | Negative_clone | C31A10 | |||||||
Mapping_data | Multi_point | 3874 | |||||||
3875 | |||||||||
3876 | |||||||||
3877 | |||||||||
3878 | |||||||||
3880 | |||||||||
3881 | |||||||||
3882 | |||||||||
3883 | |||||||||
Reference (108) | |||||||||
Remark (3) | |||||||||
Method | Gene |