WormBase Tree Display for Gene: WBGene00003386
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WBGene00003386 | Evidence | Paper_evidence | WBPaper00004415 | ||||
---|---|---|---|---|---|---|---|
SMap | S_parent | Sequence | K06C4 | ||||
Identity (6) | |||||||
Gene_info | Biotype | SO:0001217 | |||||
Gene_class | mod | ||||||
Allele (72) | |||||||
Legacy_information | [Ranganathan R] modulation of locomotion defective. Resistant to effects of serotonin on locomotion. | ||||||
Strain | WBStrain00027365 | ||||||
WBStrain00055584 | |||||||
WBStrain00055581 | |||||||
WBStrain00055576 | |||||||
WBStrain00055575 | |||||||
WBStrain00055061 | |||||||
WBStrain00055570 | |||||||
WBStrain00055580 | |||||||
WBStrain00055579 | |||||||
RNASeq_FPKM (74) | |||||||
GO_annotation (37) | |||||||
Ortholog (29) | |||||||
Paralog (100) | |||||||
Structured_description | Concise_description | mod-1 encodes a serotonin-gated chloride channel; contrary to published literature, MOD-1 activity is NOT required for the enhanced slowing response exhibited by food-deprived animals upon encountering a bacterial food source; subsequent studies have shown that mod-1 mutants (n3034, ok103, nr2043) do not exhibit reduced enhanced slowing and that the behavioral defect of the original isolate and mod-1 chloride channel mutation (n3034) are genetically separable; when expressed in voltage-clamped Xenopus oocytes, MOD-1 is able to form a serotonin-gated ion channel, and when expressed in human tissue culture cells, MOD-1 exhibits behavior consistent with chloride selectivity; a rescuing MOD-1::GFP construct is expressed in the cell bodies and axons (the latter presumably due to overexpression) of neurons in the head, tail, and ventral nerve cord. | Paper_evidence | WBPaper00004415 | |||
Person_evidence | WBPerson461 | ||||||
Curator_confirmed | WBPerson1843 | ||||||
Date_last_updated | 07 Oct 2009 00:00:00 | ||||||
Automated_description | Enables serotonin binding activity and serotonin-gated chloride channel activity. Involved in several processes, including behavioral response to starvation; locomotory exploration behavior; and positive regulation of fatty acid beta-oxidation by serotonin receptor signaling pathway. Located in neuronal cell body and plasma membrane. Expressed in body wall musculature and neurons. Used to study cocaine abuse. | Paper_evidence | WBPaper00065943 | ||||
Curator_confirmed | WBPerson324 | ||||||
WBPerson37462 | |||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||
Disease_info | Experimental_model | DOID:809 | Homo sapiens | Paper_evidence | WBPaper00034643 | ||
Curator_confirmed | WBPerson324 | ||||||
Date_last_updated | 28 May 2019 00:00:00 | ||||||
Models_disease_asserted | WBDOannot00000683 | ||||||
Molecular_info | Corresponding_CDS | K06C4.6a | |||||
K06C4.6b | |||||||
K06C4.6c | |||||||
Corresponding_transcript | K06C4.6a.1 | ||||||
K06C4.6b.1 | |||||||
K06C4.6c.1 | |||||||
Other_sequence | JI466929.1 | ||||||
JI169197.1 | |||||||
JI478000.1 | |||||||
JI468889.1 | |||||||
Associated_feature | WBsf669190 | ||||||
WBsf1000785 | |||||||
WBsf1000786 | |||||||
WBsf1020115 | |||||||
WBsf1020116 | |||||||
WBsf234154 | |||||||
WBsf234155 | |||||||
WBsf234156 | |||||||
WBsf234157 | |||||||
Experimental_info | RNAi_result | WBRNAi00034017 | Inferred_automatically | RNAi_primary | |||
WBRNAi00050055 | Inferred_automatically | RNAi_primary | |||||
Expr_pattern (11) | |||||||
Drives_construct | WBCnstr00007179 | ||||||
WBCnstr00010036 | |||||||
WBCnstr00015006 | |||||||
WBCnstr00015042 | |||||||
WBCnstr00015423 | |||||||
WBCnstr00015424 | |||||||
WBCnstr00018067 | |||||||
WBCnstr00018489 | |||||||
WBCnstr00020388 | |||||||
WBCnstr00036146 | |||||||
Construct_product (5) | |||||||
Microarray_results (28) | |||||||
Expression_cluster (131) | |||||||
Interaction | WBInteraction000001399 | ||||||
WBInteraction000031265 | |||||||
WBInteraction000166111 | |||||||
WBInteraction000520738 | |||||||
WBInteraction000525285 | |||||||
Map_info | Map | V | Position | 1.72643 | Error | 0.025158 | |
Well_ordered | |||||||
Positive | Positive_clone | C38E12 | |||||
K06C4 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
Negative | Negative_clone | C31A10 | |||||
Mapping_data | Multi_point | 3874 | |||||
3875 | |||||||
3876 | |||||||
3877 | |||||||
3878 | |||||||
3880 | |||||||
3881 | |||||||
3882 | |||||||
3883 | |||||||
Reference (108) | |||||||
Remark | Positive clone C38E12 is based on stable transformation rescue [030407 ck1] | Person_evidence | WBPerson1388 | ||||
Negative clone C31A10 is based on failure to rescue [030407 ck1] | Person_evidence | WBPerson1388 | |||||
This mod-1 (cgc4415) is different from the mod-1 published in cgc3363, which is now dmo-1 | Paper_evidence | WBPaper00004415 | |||||
WBPaper00003363 | |||||||
Method | Gene |