WormBase Tree Display for Gene: WBGene00003233
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| WBGene00003233 | SMap | S_parent | Sequence | CHROMOSOME_I | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 2 | |||||||
| Name | CGC_name | mgl-2 | Person_evidence | WBPerson309 | |||||
| Sequence_name | F45H11.4 | ||||||||
| Molecular_name | F45H11.4a | ||||||||
| F45H11.4a.1 | |||||||||
| CE42117 | |||||||||
| F45H11.4b | |||||||||
| CE50437 | |||||||||
| F45H11.4c | |||||||||
| CE50511 | |||||||||
| F45H11.4b.1 | |||||||||
| F45H11.4c.1 | |||||||||
| Other_name | CELE_F45H11.4 | Accession_evidence | NDB | BX284601 | |||||
| Public_name | mgl-2 | ||||||||
| DB_info | Database | AceView | gene | 1K960 | |||||
| WormQTL | gene | WBGene00003233 | |||||||
| WormFlux | gene | WBGene00003233 | |||||||
| NDB | locus_tag | CELE_F45H11.4 | |||||||
| Panther | gene | CAEEL|EnsemblGenome=WBGene00003233|UniProtKB=G5EG10 | |||||||
| family | PTHR24060 | ||||||||
| NCBI | gene | 172914 | |||||||
| RefSeq | protein | NM_001313467.3 | |||||||
| NM_060319.6 | |||||||||
| NM_001313468.4 | |||||||||
| TrEMBL | UniProtAcc | A0A0K3AU50 | |||||||
| A0A0K3AWF7 | |||||||||
| G5EG10 | |||||||||
| UniProt_GCRP | UniProtAcc | G5EG10 | |||||||
| OMIM | gene | 604473 | |||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:31 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| 2 | 09 Jan 2008 10:02:33 | WBPerson1983 | Event | Split_into | WBGene00077521 | ||||
| Split_into | WBGene00077521 | ||||||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | mgl | ||||||||
| Allele (109) | |||||||||
| Strain | WBStrain00005599 | ||||||||
| WBStrain00047425 | |||||||||
| WBStrain00047426 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (15) | |||||||||
| Contained_in_operon | CEOP5592 | ||||||||
| CEOP5620 | |||||||||
| Ortholog (41) | |||||||||
| Paralog | WBGene00003232 | Caenorhabditis elegans | From_analysis | TreeFam | |||||
| Panther | |||||||||
| WormBase-Compara | |||||||||
| WBGene00021152 | Caenorhabditis elegans | From_analysis | TreeFam | ||||||
| Panther | |||||||||
| WormBase-Compara | |||||||||
| WBGene00018073 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| WBGene00016242 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| Structured_description | Concise_description | mgl-2 encodes a Group I metabotropic glutamate receptor (OMIM:604473, 604102, loss-of-function mutations in mice are associated with defects in long-term potentiation); by homology, MGL-2 is predicted to function as a post-synaptic G protein-coupled receptor that, in response to glutamate binding, stimulates phospholipase C activity and increases neuronal excitation, and in mammalian tissue culture cells, glutamate stimulation of MGL-2 does result in increased phosphoinositide turnover; a mutation in mgl-2 indicates that it is required for normal head movements and tap reversal reflexes, while loss of mgl-2 activity via large-scale RNAi screens indicates that MGL-2 is also required for embryogenesis; a mgl-2::GFP reporter is expressed in interneurons. | Paper_evidence | WBPaper00004651 | |||||
| WBPaper00022392 | |||||||||
| WBPaper00028607 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 24 Jun 2014 00:00:00 | ||||||||
| Automated_description | Predicted to enable G protein-coupled receptor activity involved in regulation of postsynaptic membrane potential; adenylate cyclase inhibiting G protein-coupled glutamate receptor activity; and neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration. Predicted to be involved in G protein-coupled glutamate receptor signaling pathway and regulation of glutamatergic synaptic transmission. Predicted to be located in postsynaptic density membrane. Expressed in several structures, including glutamatergic neurons; head neurons; pharyngeal nervous system; somatic nervous system; and tail neurons. Human ortholog(s) of this gene implicated in autosomal recessive spinocerebellar ataxia 13 and spinocerebellar ataxia 44. Is an ortholog of human GRM1 (glutamate metabotropic receptor 1). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:0080286 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:4593) | ||||
| DOID:0080062 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:4593) | ||||||
| Molecular_info | Corresponding_CDS | F45H11.4a | |||||||
| F45H11.4b | |||||||||
| F45H11.4c | |||||||||
| Corresponding_CDS_history | F45H11.4:wp99 | ||||||||
| F45H11.4:wp187 | |||||||||
| Corresponding_transcript | F45H11.4a.1 | ||||||||
| F45H11.4b.1 | |||||||||
| F45H11.4c.1 | |||||||||
| Other_sequence (23) | |||||||||
| Associated_feature | WBsf716950 | ||||||||
| WBsf978538 | |||||||||
| WBsf984992 | |||||||||
| WBsf984993 | |||||||||
| WBsf984994 | |||||||||
| WBsf1010539 | |||||||||
| WBsf1010540 | |||||||||
| Transcription_factor | WBTranscriptionFactor000639 | ||||||||
| Experimental_info | RNAi_result | WBRNAi00111791 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00000411 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00047453 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00003674 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern | Expr7567 | ||||||||
| Expr12337 | |||||||||
| Expr14561 | |||||||||
| Expr14562 | |||||||||
| Expr1029177 | |||||||||
| Expr1031529 | |||||||||
| Expr1151292 | |||||||||
| Expr2013551 | |||||||||
| Drives_construct | WBCnstr00005184 | ||||||||
| WBCnstr00012712 | |||||||||
| WBCnstr00020791 | |||||||||
| WBCnstr00036171 | |||||||||
| WBCnstr00041161 | |||||||||
| Construct_product | WBCnstr00020791 | ||||||||
| WBCnstr00036171 | |||||||||
| WBCnstr00041162 | |||||||||
| Microarray_results (22) | |||||||||
| Expression_cluster (133) | |||||||||
| Interaction (25) | |||||||||
| Map_info | Map | I | Position | 4.96968 | |||||
| Positive | Positive_clone | F45H11 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Mapping_data | Multi_point | 5301 | |||||||
| Pseudo_map_position | |||||||||
| Reference (25) | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| [200811 gw3] Modified Map position as it was a reverse physical that could not be fixed by automated methods. (4.96908) | |||||||||
| Method | Gene |
