WormBase Tree Display for Gene: WBGene00003225
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WBGene00003225 | SMap | S_parent | Sequence | T07C4 | |||
---|---|---|---|---|---|---|---|
Identity | Version | 2 | |||||
Name | CGC_name | mev-1 | Person_evidence | WBPerson286 | |||
Sequence_name | T07C4.7 | ||||||
Molecular_name | T07C4.7a | ||||||
T07C4.7a.1 | |||||||
CE00598 | |||||||
T07C4.7b | |||||||
CE50785 | |||||||
T07C4.7b.1 | |||||||
Other_name | cyt-1 | ||||||
sdhc-1 | Person_evidence | WBPerson205 | |||||
CELE_T07C4.7 | Accession_evidence | NDB | BX284603 | ||||
Public_name | mev-1 | ||||||
DB_info | Database (11) | ||||||
Species | Caenorhabditis elegans | ||||||
History | Version_change (2) | ||||||
Status | Live | ||||||
Gene_info (12) | |||||||
Disease_info | Potential_model | DOID:3908 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:10682) | ||
DOID:0080533 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:10682) | ||||
DOID:0050773 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:10682) | ||||
DOID:9253 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:10682) | ||||
Disease_relevance | C. elegans is used as a model system to study the molecular mechanisms underlying diabetic hyperglycemia-induced reduction in life-span; studies in the mev-1 mutant strain of C. elegans, which carries a mutation in the cytochrome b subunit of succinate dehydrogenase and displays increased mitochondrial reactive oxygen species (ROS) generation, in analogy to the situation observed in insulin-resistance, indicate that an impaired proteosomal degradation system and accumulation of misfolded/unfolded proteins underlies glucose induced life-span reduction. | Homo sapiens | Paper_evidence | WBPaper00041961 | |||
Curator_confirmed | WBPerson324 | ||||||
Date_last_updated | 11 Mar 2013 00:00:00 | ||||||
Molecular_info | Corresponding_CDS | T07C4.7a | |||||
T07C4.7b | |||||||
Corresponding_transcript | T07C4.7a.1 | ||||||
T07C4.7b.1 | |||||||
Other_sequence (104) | |||||||
Associated_feature | WBsf645557 | ||||||
WBsf659493 | |||||||
WBsf659494 | |||||||
WBsf225708 | |||||||
Experimental_info | RNAi_result (28) | ||||||
Expr_pattern | Expr4391 | ||||||
Expr1027219 | |||||||
Expr1031524 | |||||||
Expr1156340 | |||||||
Expr2013540 | |||||||
Expr2031774 | |||||||
Drives_construct | WBCnstr00000780 | ||||||
WBCnstr00036176 | |||||||
WBCnstr00042214 | |||||||
Construct_product | WBCnstr00000780 | ||||||
WBCnstr00036176 | |||||||
WBCnstr00042214 | |||||||
Regulate_expr_cluster | WBPaper00046217:mev-1(kn1)_downregulated | ||||||
WBPaper00046217:mev-1(kn1)_upregulated | |||||||
Antibody | WBAntibody00000642 | ||||||
Microarray_results (21) | |||||||
Expression_cluster (121) | |||||||
Interaction (95) | |||||||
WBProcess | WBbiopr:00000001 | ||||||
WBbiopr:00000014 | |||||||
WBbiopr:00000065 | |||||||
Map_info | Map | III | Position | 2.348 | |||
Well_ordered | |||||||
Positive | Positive_clone | T07C4 | Inferred_automatically | From sequence, transcript, pseudogene data | |||
Negative | Negative_clone | C38H2 | |||||
Mapping_data | Multi_point | 1752 | |||||
1753 | |||||||
1754 | |||||||
1755 | |||||||
1756 | |||||||
1757 | |||||||
1824 | |||||||
2407 | |||||||
3547 | |||||||
Reference (248) | |||||||
Remark | Rescue data communicated by Hartman PS | ||||||
extracted from Ishii et al. (1998) | |||||||
Positive_clone is based on transformation rescue, mutant sequence [Ishii N, Hartman PS][030403 ck1] | |||||||
Negative_clone is based on no rescue [Ishii N, Hartman PS][030403 ck1] | |||||||
[200225 pad] Modified Map position as it was a reverse physical that could not be fixed by automated methods. (2.32414) | |||||||
Method | Gene |