WormBase Tree Display for Gene: WBGene00003225
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| WBGene00003225 | SMap | S_parent | Sequence | T07C4 | ||
|---|---|---|---|---|---|---|
| Identity (6) | ||||||
| Gene_info (12) | ||||||
| Disease_info | Potential_model | DOID:3908 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:10682) | |
| DOID:0080533 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:10682) | |||
| DOID:0050773 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:10682) | |||
| DOID:9253 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:10682) | |||
| Disease_relevance | C. elegans is used as a model system to study the molecular mechanisms underlying diabetic hyperglycemia-induced reduction in life-span; studies in the mev-1 mutant strain of C. elegans, which carries a mutation in the cytochrome b subunit of succinate dehydrogenase and displays increased mitochondrial reactive oxygen species (ROS) generation, in analogy to the situation observed in insulin-resistance, indicate that an impaired proteosomal degradation system and accumulation of misfolded/unfolded proteins underlies glucose induced life-span reduction. | Homo sapiens | Paper_evidence | WBPaper00041961 | ||
| Curator_confirmed | WBPerson324 | |||||
| Date_last_updated | 11 Mar 2013 00:00:00 | |||||
| Molecular_info | Corresponding_CDS | T07C4.7a | ||||
| T07C4.7b | ||||||
| Corresponding_transcript | T07C4.7a.1 | |||||
| T07C4.7b.1 | ||||||
| Other_sequence (104) | ||||||
| Associated_feature | WBsf645557 | |||||
| WBsf659493 | ||||||
| WBsf659494 | ||||||
| WBsf225708 | ||||||
| Experimental_info | RNAi_result (28) | |||||
| Expr_pattern | Expr4391 | |||||
| Expr1027219 | ||||||
| Expr1031524 | ||||||
| Expr1156340 | ||||||
| Expr2013540 | ||||||
| Expr2031774 | ||||||
| Drives_construct | WBCnstr00000780 | |||||
| WBCnstr00036176 | ||||||
| WBCnstr00042214 | ||||||
| Construct_product | WBCnstr00000780 | |||||
| WBCnstr00036176 | ||||||
| WBCnstr00042214 | ||||||
| Regulate_expr_cluster (2) | ||||||
| Antibody | WBAntibody00000642 | |||||
| Microarray_results (21) | ||||||
| Expression_cluster (121) | ||||||
| Interaction (95) | ||||||
| WBProcess | WBbiopr:00000001 | |||||
| WBbiopr:00000014 | ||||||
| WBbiopr:00000065 | ||||||
| Map_info | Map | III | Position | 2.348 | ||
| Well_ordered | ||||||
| Positive | Positive_clone | T07C4 | Inferred_automatically | From sequence, transcript, pseudogene data | ||
| Negative | Negative_clone | C38H2 | ||||
| Mapping_data | Multi_point | 1752 | ||||
| 1753 | ||||||
| 1754 | ||||||
| 1755 | ||||||
| 1756 | ||||||
| 1757 | ||||||
| 1824 | ||||||
| 2407 | ||||||
| 3547 | ||||||
| Reference (248) | ||||||
| Remark | Rescue data communicated by Hartman PS | |||||
| extracted from Ishii et al. (1998) | ||||||
| Positive_clone is based on transformation rescue, mutant sequence [Ishii N, Hartman PS][030403 ck1] | ||||||
| Negative_clone is based on no rescue [Ishii N, Hartman PS][030403 ck1] | ||||||
| [200225 pad] Modified Map position as it was a reverse physical that could not be fixed by automated methods. (2.32414) | ||||||
| Method | Gene |
