WormBase Tree Display for Gene: WBGene00003222
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WBGene00003222 | Evidence | CGC_data_submission | |||||||
---|---|---|---|---|---|---|---|---|---|
SMap | S_parent | Sequence | Y2H9A | ||||||
Identity | Version | 1 | |||||||
Name (5) | |||||||||
DB_info | Database (13) | ||||||||
Species | Caenorhabditis elegans | ||||||||
History | Version_change | 1 | 07 Apr 2004 11:29:31 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
Status | Live | ||||||||
Gene_info | Biotype | SO:0001217 | |||||||
Gene_class | mes | ||||||||
Allele (85) | |||||||||
Legacy_information | [C.elegansII] bn50 : grandchildless, progeny undergo normal embryogenesis but develop into agametic adults(only 10 germ cells made). Normal P granule staining. XO germ line much less affected.OA3: bn23, bn58, bn67 (all similar). [Capowski et al. 1991; SS] | ||||||||
Strain | WBStrain00022581 | ||||||||
WBStrain00034440 | |||||||||
WBStrain00036937 | |||||||||
WBStrain00029957 | |||||||||
RNASeq_FPKM (74) | |||||||||
GO_annotation (31) | |||||||||
Ortholog (83) | |||||||||
Paralog (19) | |||||||||
Structured_description | Concise_description | mes-4 encodes a SET domain-containing protein that also contains three plant homeodomain (PHD) fingers; MES-4 is required maternally for normal germline development, but in contrast to MES-2, -3, and -6, does not appear to be required for somatic anteroposterior patterning; in germline development, MES-4 activity is essential for regulating active chromatin states and for excluding the MES-2/MES-3/MES-6 chromatin repression complex from the autosomes; MES-4 is also required for germline silencing of repetitive transgene arrays; MES-4 localizes to autosomes, and is detectable in the distal, mitotic region of the germline, in meiotic germ cells during late pachytene, and in oocytes; MES-4 is detected in all somatic and germline nuclei of the early embryo, but by the 100-cell stage, its expression becomes restricted to the primordial germ cells, Z2 and Z3; exclusion of MES-4 from X chromosomes requires the activity of the MES-2, -3, -6 complex. | Paper_evidence | WBPaper00002979 | |||||
WBPaper00005301 | |||||||||
WBPaper00005923 | |||||||||
Curator_confirmed | WBPerson1843 | ||||||||
Date_last_updated | 30 Jul 2004 00:00:00 | ||||||||
Automated_description | Enables histone H3K36 methyltransferase activity. Involved in germ-line sex determination and heterochromatin formation. Acts upstream of or within with a positive effect on dosage compensation by hypoactivation of X chromosome. Located in X chromosome; autosome; and nuclear chromosome. Part of chromatin. Expressed in Z2; Z3; and germ line. Human ortholog(s) of this gene implicated in several diseases, including Sotos syndrome 1; lung non-small cell carcinoma; and neuroblastoma. Is an ortholog of human NSD1 (nuclear receptor binding SET domain protein 1); NSD2 (nuclear receptor binding SET domain protein 2); and NSD3 (nuclear receptor binding SET domain protein 3). | Paper_evidence | WBPaper00065943 | ||||||
Curator_confirmed | WBPerson324 | ||||||||
WBPerson37462 | |||||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS292 version of WormBase | ||||||||
Date_last_updated | 24 Apr 2024 00:00:00 | ||||||||
Disease_info | Potential_model | DOID:0112103 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:14234) | ||||
DOID:3908 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:12766) | ||||||
DOID:10907 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:14234) | ||||||
DOID:14748 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:14234) | ||||||
DOID:769 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:14234) | ||||||
DOID:8692 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:12767) | ||||||
DOID:9119 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:14234) | ||||||
Molecular_info | Corresponding_CDS | Y2H9A.1 | |||||||
Corresponding_CDS_history | Y2H9A.1:wp51 | ||||||||
Corresponding_transcript | Y2H9A.1.1 | ||||||||
Other_sequence | AF233290 | ||||||||
CBC09012_1 | |||||||||
CBC03017_1 | |||||||||
CRC01044_1 | |||||||||
CR09817 | |||||||||
CR07209 | |||||||||
CRC02608_1 | |||||||||
Associated_feature (11) | |||||||||
Gene_product_binds (4418) | |||||||||
Transcription_factor | WBTranscriptionFactor000137 | ||||||||
Experimental_info | RNAi_result (41) | ||||||||
Expr_pattern | Expr1905 | ||||||||
Expr4222 | |||||||||
Expr14367 | |||||||||
Expr1027992 | |||||||||
Expr1031522 | |||||||||
Expr1159295 | |||||||||
Expr1200052 | |||||||||
Expr2013532 | |||||||||
Expr2031766 | |||||||||
Drives_construct | WBCnstr00036178 | ||||||||
Construct_product | WBCnstr00036178 | ||||||||
Regulate_expr_cluster | WBPaper00028483:Down_mes-4_vs_WT | ||||||||
WBPaper00028483:Up_mes-4_vs_WT | |||||||||
WBPaper00041688:mes-2_mes-4_downregulated | |||||||||
WBPaper00041688:mes-2_mes-4_upregulated | |||||||||
WBPaper00064315:mes-4(bn73)_downregulated_EGCs | |||||||||
WBPaper00064315:mes-4(bn73)_downregulated_PGCs | |||||||||
WBPaper00064315:mes-4(bn73)_upregulated_EGCs | |||||||||
WBPaper00064315:mes-4(bn73)_upregulated_PGCs | |||||||||
Antibody (4) | |||||||||
Microarray_results (18) | |||||||||
Expression_cluster (153) | |||||||||
Interaction (84) | |||||||||
Map_info (5) | |||||||||
Reference (120) | |||||||||
Remark | Sequence connection from [Strome S] | ||||||||
Method | Gene |