WormBase Tree Display for Gene: WBGene00003178
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| WBGene00003178 | Evidence | Paper_evidence | WBPaper00005356 | ||||||
|---|---|---|---|---|---|---|---|---|---|
| SMap | S_parent | Sequence | F57H12 | ||||||
| Identity | Version | 2 | |||||||
| Name | CGC_name | mec-17 | Person_evidence | WBPerson95 | |||||
| Sequence_name | F57H12.7 | ||||||||
| Molecular_name | F57H12.7a | ||||||||
| F57H12.7a.1 | |||||||||
| CE17128 | |||||||||
| F57H12.7b | |||||||||
| CE49511 | |||||||||
| F57H12.7b.1 | |||||||||
| Other_name | atat-1 | Paper_evidence | WBPaper00037771 | ||||||
| CELE_F57H12.7 | Accession_evidence | NDB | BX284604 | ||||||
| Public_name | mec-17 | ||||||||
| DB_info | Database (12) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:31 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| 2 | 30 Nov 2010 15:52:03 | WBPerson2970 | Name_change | Other_name | atat-1 | ||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | mec | ||||||||
| Allele (42) | |||||||||
| Legacy_information | [C.elegansII] u265 : larvae touch sensitive, older animals touch insensitive; mec-3:lacZ expression not maintained in touch cells. NA1. [Chalfie and Au 1989; Way and Chalfie 1989; TU] | ||||||||
| Strain | WBStrain00035052 | ||||||||
| WBStrain00032389 | |||||||||
| WBStrain00035038 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (20) | |||||||||
| Ortholog (34) | |||||||||
| Paralog | WBGene00021059 | Caenorhabditis elegans | From_analysis | TreeFam | |||||
| Panther | |||||||||
| WormBase-Compara | |||||||||
| Structured_description | Concise_description | mec-17 encodes an alpha-tubulin acetyltransferase; MEC-17 activity is required for maintaining the differentiated state of the touch receptor neurons, and hence the animal's touch sensitivity, during later stages of larval development; MEC-17 and W06B11.1 function redundantly for acetylation of K40 on MEC-12 alpha-tubulin; mec-17 is expressed solely in the touch receptor cells from late embryogenesis through adulthood, and this expression is dependent upon the MEC-3 LIM homeodomain transcription factor; in turn, as MEC-17 is necessary for maintaining differentiated touch receptors, its activity is required for continued expression of MEC-3 and the MEC-7 beta-tubulin. | Paper_evidence | WBPaper00001125 | |||||
| WBPaper00001237 | |||||||||
| WBPaper00001829 | |||||||||
| WBPaper00005356 | |||||||||
| WBPaper00037127 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 20 Sep 2010 00:00:00 | ||||||||
| Automated_description | Enables tubulin N-acetyltransferase activity. Involved in mechanoreceptor differentiation and thigmotaxis. Predicted to be located in microtubule. Expressed in touch receptor neurons. Used to study neurodegenerative disease. Is an ortholog of human ATAT1 (alpha tubulin acetyltransferase 1). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Experimental_model | DOID:1289 | Homo sapiens | Paper_evidence | WBPaper00044649 | ||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 21 Sep 2018 00:00:00 | ||||||||
| Disease_relevance | Axonal degeneration arises as a consequence of neuronal injury and is a characteristic of a number of neurodegenerative diseases; in C. elegans the loss of the mec-17 alpha-tubulin acetyltransferase causes adult-onset and progressive axonal degeneration via microtubule instability, reduced mitochondrial number and disrupted axonal transport. | Homo sapiens | Paper_evidence | WBPaper00044649 | |||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 23 Jan 2015 00:00:00 | ||||||||
| Models_disease_asserted | WBDOannot00000611 | ||||||||
| WBDOannot00000612 | |||||||||
| Molecular_info | Corresponding_CDS | F57H12.7a | |||||||
| F57H12.7b | |||||||||
| Corresponding_transcript | F57H12.7a.1 | ||||||||
| F57H12.7b.1 | |||||||||
| Other_sequence (26) | |||||||||
| Associated_feature | WBsf651972 | ||||||||
| WBsf668065 | |||||||||
| WBsf997092 | |||||||||
| WBsf230363 | |||||||||
| Experimental_info | RNAi_result | WBRNAi00015926 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00048918 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00033055 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern | Expr10032 | ||||||||
| Expr11573 | |||||||||
| Expr11641 | |||||||||
| Expr13823 | |||||||||
| Expr1023300 | |||||||||
| Expr1031508 | |||||||||
| Expr1152657 | |||||||||
| Expr2013492 | |||||||||
| Expr2031726 | |||||||||
| Drives_construct (18) | |||||||||
| Construct_product | WBCnstr00009235 | ||||||||
| WBCnstr00036193 | |||||||||
| Microarray_results (18) | |||||||||
| Expression_cluster (180) | |||||||||
| Interaction (24) | |||||||||
| Map_info | Map | IV | Position | 3.57029 | Error | 0.005124 | |||
| Well_ordered | |||||||||
| Positive | Positive_clone | F57H12 | Inferred_automatically | From CDS info | |||||
| From sequence, transcript, pseudogene data | |||||||||
| Mapping_data | Multi_point | 1114 | |||||||
| 1115 | |||||||||
| 1116 | |||||||||
| 1117 | |||||||||
| 2067 | |||||||||
| 2068 | |||||||||
| 3628 | |||||||||
| 4932 | |||||||||
| Pos_neg_data | 2727 | ||||||||
| Reference (42) | |||||||||
| Method | Gene |
