WormBase Tree Display for Gene: WBGene00003160
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| WBGene00003160 | SMap | S_parent | Sequence | C50F4 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 2 | |||||||
| Name | CGC_name | mdf-1 | Person_evidence | WBPerson533 | |||||
| Sequence_name | C50F4.11 | ||||||||
| Molecular_name | C50F4.11 | ||||||||
| C50F4.11.1 | |||||||||
| CE28212 | |||||||||
| Other_name | mad-1 | Person_evidence | WBPerson1836 | ||||||
| CELE_C50F4.11 | Accession_evidence | NDB | BX284605 | ||||||
| Public_name | mdf-1 | ||||||||
| DB_info | Database | AceView | gene | 5K20 | |||||
| WormQTL | gene | WBGene00003160 | |||||||
| WormFlux | gene | WBGene00003160 | |||||||
| NDB | locus_tag | CELE_C50F4.11 | |||||||
| Panther | gene | CAEEL|WormBase=WBGene00003160|UniProtKB=G5EFM0 | |||||||
| family | PTHR23168 | ||||||||
| NCBI | gene | 179338 | |||||||
| RefSeq | protein | NM_073061.5 | |||||||
| TrEMBL | UniProtAcc | G5EFM0 | |||||||
| UniProt_GCRP | UniProtAcc | G5EFM0 | |||||||
| OMIM | gene | 602686 | |||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:30 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| 2 | 19 Nov 2013 09:38:25 | WBPerson2970 | Name_change | Other_name | mad-1 | ||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | mdf | ||||||||
| Allele (41) | |||||||||
| Strain (13) | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (21) | |||||||||
| Contained_in_operon | CEOP5232 | ||||||||
| Ortholog (25) | |||||||||
| Structured_description | Concise_description | mdf-1 encodes a coiled-coil domain-containing protein that is orthologous to the Saccharomyces cerevisiae mitotic spindle checkpoint protein Mad1p; consistent with a role as a checkpoint protein, MDF-1 is required in C. elegans for mitotic genome stability and hence, long-term survival and fertility; in vitro, MDF-1 interacts with MDF-2, the C. elegans Mad2p ortholog. | Paper_evidence | WBPaper00003830 | |||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 08 Nov 2005 00:00:00 | ||||||||
| Automated_description | Enables protein kinase binding activity. Involved in embryo development; mitotic spindle assembly; and regulation of mitotic sister chromatid separation. Located in kinetochore; nuclear membrane; and nuclear periphery. Expressed in Z1; Z2; Z3; Z4; and intestine. Human ortholog(s) of this gene implicated in lymphoma; mosaic variegated aneuploidy syndrome; and prostate cancer. Is an ortholog of human MAD1L1 (mitotic arrest deficient 1 like 1). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:0080688 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:6762) | ||||
| DOID:10283 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:6762) | ||||||
| DOID:0060058 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:6762) | ||||||
| Molecular_info | Corresponding_CDS | C50F4.11 | |||||||
| Corresponding_CDS_history | C50F4.11:wp52 | ||||||||
| Corresponding_transcript | C50F4.11.1 | ||||||||
| Other_sequence (28) | |||||||||
| Associated_feature | WBsf652921 | ||||||||
| WBsf669237 | |||||||||
| WBsf669238 | |||||||||
| WBsf669239 | |||||||||
| WBsf1000930 | |||||||||
| WBsf234238 | |||||||||
| Experimental_info | RNAi_result (30) | ||||||||
| Expr_pattern | Expr8125 | ||||||||
| Expr8392 | |||||||||
| Expr11609 | |||||||||
| Expr1027973 | |||||||||
| Expr1031495 | |||||||||
| Expr1146906 | |||||||||
| Expr1200216 | |||||||||
| Expr2013463 | |||||||||
| Expr2031697 | |||||||||
| Drives_construct | WBCnstr00018976 | ||||||||
| WBCnstr00018982 | |||||||||
| WBCnstr00018983 | |||||||||
| WBCnstr00018984 | |||||||||
| WBCnstr00018985 | |||||||||
| WBCnstr00018986 | |||||||||
| WBCnstr00018988 | |||||||||
| WBCnstr00018989 | |||||||||
| WBCnstr00036209 | |||||||||
| Construct_product (12) | |||||||||
| Antibody | WBAntibody00001380 | ||||||||
| Microarray_results (17) | |||||||||
| Expression_cluster (117) | |||||||||
| Interaction (59) | |||||||||
| Map_info | Map | V | Position | 2.04634 | Error | 0.000363 | |||
| Positive | Positive_clone | C50F4 | Inferred_automatically | From CDS info | |||||
| From sequence, transcript, pseudogene data | |||||||||
| Mapping_data | Multi_point | 4485 | |||||||
| 4995 | |||||||||
| Pseudo_map_position | |||||||||
| Reference (48) | |||||||||
| Remark | Sequence connection based on gk2 allele linking to both Locus and Sequence objects [020821 krb] | ||||||||
| Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | ||||||||
| This gene has been named mad (Mitotic Arrest Deficient) in other species and so mad-1 has been added as an other_name | |||||||||
| Method | Gene |
