WormBase Tree Display for Gene: WBGene00003153
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WBGene00003153 | SMap | S_parent | Sequence | Y67D8C | |||
---|---|---|---|---|---|---|---|
Identity (6) | |||||||
Gene_info | Biotype | SO:0001217 | |||||
Gene_class | mca | ||||||
Allele (491) | |||||||
Legacy_information | [Kraev A] mca for Membrane Calcium ATPase. No mutants known. See mca-1. | ||||||
Strain | WBStrain00032351 | ||||||
WBStrain00008044 | |||||||
WBStrain00008045 | |||||||
WBStrain00007591 | |||||||
RNASeq_FPKM (74) | |||||||
GO_annotation (30) | |||||||
Ortholog (55) | |||||||
Paralog (14) | |||||||
Structured_description | Concise_description | mca-3 encodes one of three C. elegans plasma membrane Ca2+ ATPases (PMCAs); by homology, MCA-3 is predicted to function as a molecular pump that couples ATP hydrolysis to extrusion of cytosolic Ca2+; mca-3 activity is required for coelomoycte endocytosis, normal coordinated locomotion, and embryonic and larval development; in regulating endocytosis, MCA-3 is required specifically in the early stages for recruitment of the endocytic machinery to the plasma membrane; an mca-3::gfp reporter is expressed from embryogenesis through adulthood and seen in body wall muscle, the nervous system, intestine, and coelomocytes; in coelomocytes, an MCA-3::GFP fusion protein localizes to the plasma membrane. | Paper_evidence | WBPaper00003407 | |||
WBPaper00004883 | |||||||
WBPaper00029172 | |||||||
Curator_confirmed | WBPerson1843 | ||||||
Date_last_updated | 30 Apr 2007 00:00:00 | ||||||
Automated_description | Predicted to enable P-type calcium transporter activity. Involved in several processes, including negative regulation of cytosolic calcium ion concentration; nematode larval development; and positive regulation of growth rate. Located in plasma membrane. Expressed in body wall musculature; coelomocyte; intestine; nervous system; and touch receptor neurons. Human ortholog(s) of this gene implicated in X-linked spinocerebellar ataxia 1; autosomal dominant intellectual developmental disorder; and nonsyndromic deafness (multiple). Is an ortholog of several human genes including ATP2B1 (ATPase plasma membrane Ca2+ transporting 1); ATP2B2 (ATPase plasma membrane Ca2+ transporting 2); and ATP2B3 (ATPase plasma membrane Ca2+ transporting 3). | Paper_evidence | WBPaper00065943 | ||||
Curator_confirmed | WBPerson324 | ||||||
WBPerson37462 | |||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||
Disease_info | Potential_model | DOID:0060307 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:814) | ||
DOID:0111829 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:816) | ||||
DOID:0050564 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:815) | ||||
DOID:0110467 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:815) | ||||
DOID:11714 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:814,HGNC:815,HGNC:816,HGNC:817) | ||||
DOID:10591 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:814,HGNC:815,HGNC:816,HGNC:817) | ||||
Molecular_info | Corresponding_CDS | Y67D8C.10a | |||||
Y67D8C.10b | |||||||
Y67D8C.10c | |||||||
Y67D8C.10d | |||||||
Y67D8C.10e | |||||||
Corresponding_transcript (11) | |||||||
Other_sequence (125) | |||||||
Associated_feature (33) | |||||||
Experimental_info | RNAi_result | WBRNAi00103077 | Inferred_automatically | RNAi_primary | |||
WBRNAi00009413 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00110940 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00057995 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00026914 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00103078 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00103079 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00066558 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00021260 | Inferred_automatically | RNAi_primary | |||||
Expr_pattern (8) | |||||||
Drives_construct | WBCnstr00008391 | ||||||
Construct_product | WBCnstr00000243 | ||||||
WBCnstr00000246 | |||||||
WBCnstr00000247 | |||||||
Microarray_results (52) | |||||||
Expression_cluster (158) | |||||||
Interaction (38) | |||||||
Map_info | Map | IV | Position | -5.83327 | Error | 0.101838 | |
Positive | Positive_clone | Y67D8 | |||||
Y67D8C | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
Mapping_data | Multi_point | 3954 | |||||
Reference (11) | |||||||
Method | Gene |