WormBase Tree Display for Gene: WBGene00002275
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WBGene00002275 | Evidence | Paper_evidence | WBPaper00004339 | ||||
---|---|---|---|---|---|---|---|
SMap | S_parent | Sequence | CHROMOSOME_II | ||||
Identity (6) | |||||||
Gene_info (10) | |||||||
Disease_info | Experimental_model | DOID:11726 | Homo sapiens | Paper_evidence | WBPaper00046424 | ||
Accession_evidence | OMIM | 181350 | |||||
Curator_confirmed | WBPerson324 | ||||||
Date_last_updated | 04 Jan 2013 00:00:00 | ||||||
DOID:0110243 | Homo sapiens | Paper_evidence | WBPaper00059881 | ||||
Curator_confirmed | WBPerson324 | ||||||
Date_last_updated | 27 Jun 2020 00:00:00 | ||||||
Potential_model | DOID:0111536 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:28887) | |||
DOID:0110243 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:21244) | ||||
Disease_relevance | Mutations in the human ortholog of lem-2, LEMD3, which encodes the MAN1 nuclear membrane protein, are found in Buschke-Ollendorff syndrome, Melorheostosis and Osteopoikilosis; MAN1 belongs to the family of LEM domain proteins that bind lamin and include nuclear lamina proteins like Emerin, LEM2/NET25, and several others; much of the knowledge of the organization and assembly of the nuclear lamina has come from studies in elegans; studies in elegans have demonstrated the overlapping roles of emerin and LEM-2 in embryogenesis, cell proliferation, lamin and heterochromatin organization; worm emerin and lem-2 are also involved in mitosis, smooth and striated muscle function, lifespan and meiotic progression, pointing to the many underlying processes that may affect disease phenotypes. | Homo sapiens | Paper_evidence | WBPaper00040268 | |||
Accession_evidence | OMIM | 166700 | |||||
155950 | |||||||
16670 | |||||||
607844 | |||||||
Curator_confirmed | WBPerson324 | ||||||
Date_last_updated | 06 Mar 2012 00:00:00 | ||||||
Models_disease_asserted | WBDOannot00000047 | ||||||
WBDOannot00000768 | |||||||
WBDOannot00000769 | |||||||
WBDOannot00000770 | |||||||
WBDOannot00000771 | |||||||
Molecular_info | Corresponding_CDS | W01G7.5 | |||||
Corresponding_transcript | W01G7.5.1 | ||||||
Other_sequence (19) | |||||||
Associated_feature | WBsf644830 | ||||||
WBsf658388 | |||||||
WBsf976399 | |||||||
WBsf976400 | |||||||
WBsf981354 | |||||||
WBsf990618 | |||||||
WBsf1013767 | |||||||
WBsf222419 | |||||||
WBsf222420 | |||||||
WBsf222421 | |||||||
Experimental_info | RNAi_result (15) | ||||||
Expr_pattern | Expr9180 | ||||||
Expr10879 | |||||||
Expr11504 | |||||||
Expr12212 | |||||||
Expr1014258 | |||||||
Expr1031341 | |||||||
Expr1158080 | |||||||
Expr2013044 | |||||||
Expr2031276 | |||||||
Drives_construct | WBCnstr00018933 | ||||||
WBCnstr00020602 | |||||||
Construct_product | WBCnstr00001838 | ||||||
WBCnstr00017548 | |||||||
WBCnstr00018933 | |||||||
WBCnstr00020602 | |||||||
Regulate_expr_cluster | WBPaper00044786:emr-1(RNAi);lem-2(tm1582)_downregulated | ||||||
WBPaper00044786:emr-1(RNAi);lem-2(tm1582)_upregulated | |||||||
WBPaper00044786:lem-2(tm1582)_downregulated | |||||||
WBPaper00044786:lem-2(tm1582)_upregulated | |||||||
Antibody | WBAntibody00000308 | ||||||
WBAntibody00000309 | |||||||
WBAntibody00000310 | |||||||
WBAntibody00000311 | |||||||
WBAntibody00001855 | |||||||
WBAntibody00002216 | |||||||
WBAntibody00002346 | |||||||
Microarray_results (22) | |||||||
Expression_cluster (158) | |||||||
Interaction (35) | |||||||
Map_info | Map | II | Position | 22.3934 | Error | 0.004999 | |
Positive | Positive_clone | W01G7 | Inferred_automatically | From CDS info | |||
From sequence, transcript, pseudogene data | |||||||
Mapping_data | Multi_point (2) | ||||||
Pseudo_map_position | |||||||
Reference (43) | |||||||
Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||
Method | Gene |