WormBase Tree Display for Gene: WBGene00002245
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WBGene00002245 | SMap | S_parent | Sequence | CHROMOSOME_IV | |||
---|---|---|---|---|---|---|---|
Identity (6) | |||||||
Gene_info | Biotype | SO:0001217 | |||||
Gene_class | lag | ||||||
Allele (226) | |||||||
Possibly_affected_by | WBVar02153178 | ||||||
WBVar02157780 | |||||||
Legacy_information | [Lambie EJ] larval arrest at L1, characteristic Lag (Lin-12 and Glp-1) phenotype: rectum/anus and excretory cell absent (98%), sometimes twisted nose (12%). NA6 (other alleles weaker: q416 sometimes viable and fertile at 20C; q426 low larval lethality) | ||||||
[C.elegansII] q385 : larval arrest at L1, characteristic Lag (Lin-12 and Glp-1) phenotype: rectum/anus and excretory cell absent (98%), sometimes twisted nose (12%). OA>10 (other alleles mostly weaker): q416 (sometimes viable and fertile at 20C), q426 (low larval lethality), om13 (viable, impenetrant embryonic and larval lethality; strong Ego, enhances glp-1(bn18ts)), om27(viable, Ego), om108 (viable, Ego), etc. Cloned: 2.6 kb transcript, encodes protein with high similarity to Drosophila Suppressor of hairless. [Lambie and Kimble 1991; JK] | |||||||
Strain | WBStrain00022545 | ||||||
WBStrain00022552 | |||||||
WBStrain00034581 | |||||||
WBStrain00007146 | |||||||
WBStrain00030024 | |||||||
WBStrain00051949 | |||||||
WBStrain00052019 | |||||||
WBStrain00051599 | |||||||
WBStrain00051810 | |||||||
WBStrain00054794 | |||||||
RNASeq_FPKM (74) | |||||||
GO_annotation (59) | |||||||
Ortholog (59) | |||||||
Structured_description | Concise_description | lag-1 encodes a transcription factor orthologous to members of the CSL (CBF1, Suppressor of Hairless, LAG-1) family that is highly conserved amongst metazoans; during development, LAG-1 functions as a downstream effector in both the lin-12- and glp-1-mediated Notch-like signaling pathways and accordingly, is required for such processes as germline induction, AC/VU lateral signaling, and embryonic development; LAG-1 can bind a consensus CSL family binding site found in multiple copies in the predicted regulatory regions of lin-12, glp-1, and lag-1, thus implicating LAG-1 as an important component of the positive feedback loop observed in the LIN-12/GLP-1 signaling pathway. | Paper_evidence | WBPaper00001423 | |||
WBPaper00002452 | |||||||
WBPaper00004120 | |||||||
WBPaper00004589 | |||||||
Curator_confirmed | WBPerson1843 | ||||||
Date_last_updated | 05 Jun 2006 00:00:00 | ||||||
Automated_description | Enables Notch binding activity; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and transcription coactivator binding activity. Involved in several processes, including cell differentiation; dauer exit; and regulation of DNA-templated transcription. Located in nucleus. Part of RNA polymerase II transcription regulator complex and chromatin. Expressed in several structures, including P4.p; P5.p; P6.p; P7.p; and P8.p. Human ortholog(s) of this gene implicated in Adams-Oliver syndrome and dilated cardiomyopathy. Is an ortholog of human RBPJ (recombination signal binding protein for immunoglobulin kappa J region). | Paper_evidence | WBPaper00065943 | ||||
Curator_confirmed (2) | |||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||
Disease_info | Potential_model (2) | ||||||
Molecular_info | Corresponding_CDS | K08B4.1a | |||||
K08B4.1b | |||||||
K08B4.1c | |||||||
K08B4.1d | |||||||
Corresponding_transcript | K08B4.1a.1 | ||||||
K08B4.1b.1 | |||||||
K08B4.1c.1 | |||||||
K08B4.1d.1 | |||||||
Other_sequence (53) | |||||||
Associated_feature (33) | |||||||
Gene_product_binds (26) | |||||||
Transcription_factor | WBTranscriptionFactor000101 | ||||||
Experimental_info (11) | |||||||
Map_info | Map | IV | Position | 2.97979 | Error | 0.005015 | |
Well_ordered | |||||||
Positive | Positive_clone | F43A12 | |||||
K08B4 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
M02G2 | |||||||
Negative | Negative_clone | M03D4 | |||||
Mapping_data | Multi_point | 2827 | |||||
2828 | |||||||
3371 | |||||||
3372 | |||||||
3373 | |||||||
3374 | |||||||
4900 | |||||||
Reference (143) | |||||||
Remark | data extracted from Lambie & Kimble 1991 | ||||||
Datum extracted from Christensen et al. (1996) | |||||||
M03D4.3 has been fused with K08B4.1, latter is lag-1 in sequence annotation. [sdm 05/00] | |||||||
Method | Gene |