WormBase Tree Display for Gene: WBGene00002233
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| WBGene00002233 | SMap | S_parent | Sequence | C25B8 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | kqt-1 | Person_evidence | WBPerson655 | |||||
| Sequence_name | C25B8.1 | ||||||||
| Molecular_name | C25B8.1a | ||||||||
| C25B8.1a.1 | |||||||||
| CE27086 | |||||||||
| C25B8.1b | |||||||||
| CE30875 | |||||||||
| C25B8.1b.1 | |||||||||
| Other_name | klq-1 | ||||||||
| CELE_C25B8.1 | Accession_evidence | NDB | BX284606 | ||||||
| Public_name | kqt-1 | ||||||||
| DB_info | Database (11) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:27 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | kqt | ||||||||
| Allele (129) | |||||||||
| Strain | WBStrain00036366 | ||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (21) | |||||||||
| Ortholog (48) | |||||||||
| Paralog (13) | |||||||||
| Structured_description | Concise_description | kqt-1 encodes one of three C. elegans KCNQ-like potassium channel subunits that, with respect to humans, is most similar to the KCNQ2-5 subfamily of channel proteins; although loss of KQT-1 activity via large-scale RNAi screens results in no obvious abnormalities, KQT-1 likely functions to regulate cellular excitability as expression of KQT-1 in Xenopus oocytes can produce K+ channel currents that functionally resemble vertebrate M-currents; activity of these KQT-1 channels can be suppressed by coexpression with the human M1 muscarinic receptor and treatment with diacylglycerol analogs; a KQT-1::GFP translational fusion is expressed in pharyngeal muscle cells, in the anterior and posterior mechanosensory neurons ALM and PLM, and in some head neurons. | Paper_evidence | WBPaper00004103 | |||||
| WBPaper00025059 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| WBPerson567 | |||||||||
| Date_last_updated | 15 Sep 2005 00:00:00 | ||||||||
| Automated_description | Enables potassium channel activity. Involved in G protein-coupled acetylcholine receptor signaling pathway; intracellular signal transduction; and potassium ion transport. Predicted to be located in plasma membrane and synapse. Predicted to be part of voltage-gated potassium channel complex. Expressed in head neurons; pharyngeal muscle cell; and touch receptor neurons. Used to study developmental and epileptic encephalopathy and long QT syndrome. Human ortholog(s) of this gene implicated in several diseases, including auditory system disease (multiple); autistic disorder; and electroclinical syndrome (multiple). Is an ortholog of human KCNQ4 (potassium voltage-gated channel subfamily Q member 4). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info (3) | |||||||||
| Models_disease_in_annotation | WBDOannot00000063 | ||||||||
| WBDOannot00000301 | |||||||||
| Molecular_info | Corresponding_CDS | C25B8.1a | |||||||
| C25B8.1b | |||||||||
| Corresponding_transcript | C25B8.1a.1 | ||||||||
| C25B8.1b.1 | |||||||||
| Other_sequence (6) | |||||||||
| Associated_feature (20) | |||||||||
| Experimental_info | RNAi_result | WBRNAi00041161 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00001487 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00075817 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00041162 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00011145 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00041160 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern | Expr3234 | ||||||||
| Expr1018104 | |||||||||
| Expr1031310 | |||||||||
| Expr1145191 | |||||||||
| Expr2012976 | |||||||||
| Expr2031208 | |||||||||
| Drives_construct | WBCnstr00011240 | ||||||||
| WBCnstr00036369 | |||||||||
| Construct_product | WBCnstr00011240 | ||||||||
| WBCnstr00036369 | |||||||||
| Microarray_results (26) | |||||||||
| Expression_cluster (146) | |||||||||
| Interaction | WBInteraction000169452 | ||||||||
| WBInteraction000173470 | |||||||||
| WBInteraction000264869 | |||||||||
| WBInteraction000301540 | |||||||||
| WBInteraction000544613 | |||||||||
| WBInteraction000578572 | |||||||||
| Map_info | Map | X | Position | -2.69956 | Error | 0.014064 | |||
| Positive | Positive_clone | C25B8 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Mapping_data | Multi_point | 4237 | |||||||
| Pseudo_map_position | |||||||||
| Reference (12) | |||||||||
| Picture | WBPicture0000013535 | ||||||||
| Remark | Sequence connection from [Thomas JH, Wei A] | ||||||||
| Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | ||||||||
| Method | Gene |
