WormBase Tree Display for Gene: WBGene00002073
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WBGene00002073 | SMap | S_parent | Sequence | F26B1 | |||
---|---|---|---|---|---|---|---|
Identity (6) | |||||||
Gene_info | Biotype | SO:0001217 | |||||
Gene_class | ima | ||||||
Allele (33) | |||||||
Strain | WBStrain00003849 | ||||||
WBStrain00003850 | |||||||
WBStrain00003851 | |||||||
WBStrain00040617 | |||||||
RNASeq_FPKM (74) | |||||||
GO_annotation (32) | |||||||
Ortholog (49) | |||||||
Paralog | WBGene00002072 | Caenorhabditis elegans | From_analysis | Panther | |||
WormBase-Compara | |||||||
WBGene00002074 | Caenorhabditis elegans | From_analysis | Panther | ||||
WormBase-Compara | |||||||
WBGene00009956 | Caenorhabditis elegans | From_analysis | Panther | ||||
WormBase-Compara | |||||||
Structured_description | Concise_description | ima-2 encodes one of three C. elegans importin alpha proteins; IMA-2 is predicted to function as an adaptor protein that regulates import of nuclear proteins; during development, ima-2 activity is required for normal germline and embryonic mitoses, specifically for proper chromosome segregration and nuclear reassembly; IMA-2 expression is detected in germ cells, oocytes, and early embryonic cells in a dynamic pattern that depends upon the stage of the cell cycle: in germ cells and early embryonic cells at interphase, IMA-2 is cytoplasmic and nuclear envelope-associated, while in oocytes, IMA-2 is cytoplasmic and intranuclear; during mitoses (prometaphase until telophase), IMA-2 surrounds condensed chromosomes, but does not associate with the mitotic spindle; early somatic expression of maternal IMA-2 is diluted upon cell division, with appreciable expression subsequently seen only in the germ line. | Paper_evidence (2) | ||||
Curator_confirmed | WBPerson1843 | ||||||
Date_last_updated | 26 Oct 2006 00:00:00 | ||||||
Automated_description | Enables nuclear import signal receptor activity. Involved in several processes, including organelle organization; protein import into nucleus; and regulation of chromosome segregation. Located in cytoplasm and nuclear envelope. Expressed in Z2; Z3; and germ line. Is an ortholog of human KPNA2 (karyopherin subunit alpha 2) and KPNA7 (karyopherin subunit alpha 7). | Paper_evidence | WBPaper00065943 | ||||
Curator_confirmed | WBPerson324 | ||||||
WBPerson37462 | |||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||
Disease_info | Potential_model | EFO:MONDO:0014769 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:21839) | ||
Molecular_info | Corresponding_CDS | F26B1.3 | |||||
Corresponding_transcript | F26B1.3.1 | ||||||
Other_sequence (68) | |||||||
Associated_feature | WBsf976724 | ||||||
WBsf976725 | |||||||
WBsf976726 | |||||||
WBsf976727 | |||||||
WBsf976728 | |||||||
WBsf217793 | |||||||
Experimental_info | RNAi_result (15) | ||||||
Expr_pattern | Expr1340 | ||||||
Expr1341 | |||||||
Expr2436 | |||||||
Expr1015623 | |||||||
Expr1031226 | |||||||
Expr1149508 | |||||||
Expr2012726 | |||||||
Expr2030963 | |||||||
Drives_construct | WBCnstr00036474 | ||||||
Construct_product | WBCnstr00036474 | ||||||
Antibody | WBAntibody00000368 | ||||||
Microarray_results (22) | |||||||
Expression_cluster (247) | |||||||
Interaction (209) | |||||||
Map_info | Map | I | Position | 0.958776 | Error | 0.01404 | |
Positive | Positive_clone | F26B1 | Inferred_automatically | From CDS info | |||
From sequence, transcript, pseudogene data | |||||||
Mapping_data | Multi_point | 4438 | |||||
Pseudo_map_position | |||||||
Reference (13) | |||||||
Remark | Sequence connection from [Geles KG, Adam SA]. krb 13/11/01 | ||||||
Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | ||||||
Method | Gene |