WormBase Tree Display for Gene: WBGene00001985
expand all nodes | collapse all nodes | view schema
WBGene00001985 | SMap | S_parent | Sequence | C18E3 | |||
---|---|---|---|---|---|---|---|
Identity (6) | |||||||
Gene_info | Biotype | SO:0001217 | |||||
Gene_class | hop | ||||||
Allele (48) | |||||||
Legacy_information | [Li X, Greenwald I] hop for Homolog Of Presenilin. No mutants known. hop-1(RNAi) has no obvious effect on WT, but leads to synthetic lethality in sel-12. Transgenic hop-1 rescues Egl phenotype of sel-12. Predicted gene C18E3.8 | ||||||
Strain | WBStrain00004785 | ||||||
WBStrain00008037 | |||||||
RNASeq_FPKM (74) | |||||||
GO_annotation (41) | |||||||
Ortholog (23) | |||||||
Paralog | WBGene00004769 | Caenorhabditis elegans | From_analysis | TreeFam | |||
Panther | |||||||
WormBase-Compara | |||||||
WBGene00004958 | Caenorhabditis elegans | From_analysis | Panther | ||||
WormBase-Compara | |||||||
Structured_description | Concise_description | hop-1 encodes one of three C. elegans presenilins (the other two presenilins are encoded by sel-12 and spe-4); originally identified on the basis of its sequence similarity to SEL-12 and the human PS1 and PS2 presenilins, HOP-1 has been shown to function redundantly with SEL-12 in embryonic, larval, and germline development and thus, to likely function by regulating LIN-12/GLP-1 signaling; in addition, hop-1 can functionally substitute for sel-12 by rescuing the egg-laying and vulval development defects of sel-12 mutants; hop-1 transcription appears to be regulated, at least in part, by the C. elegans spr genes, some of which encode orthologs of the mammalian CoREST repressor complex. | Paper_evidence | WBPaper00002932 | |||
WBPaper00003421 | |||||||
WBPaper00005564 | |||||||
Curator_confirmed | WBPerson1843 | ||||||
Date_last_updated | 05 Mar 2008 00:00:00 | ||||||
Automated_description | Predicted to enable endopeptidase activity. Involved in several processes, including egg-laying behavior; positive regulation of Notch signaling pathway; and regulation of vulval development. Predicted to be located in several cellular components, including apical plasma membrane; cytoplasm; and plasma membrane bounded cell projection. | Paper_evidence | WBPaper00065943 | ||||
Curator_confirmed | WBPerson324 | ||||||
WBPerson37462 | |||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||
Molecular_info | Corresponding_CDS | C18E3.8 | |||||
Corresponding_transcript | C18E3.8.1 | ||||||
Other_sequence | CRC04478_1 | ||||||
CR03774 | |||||||
Associated_feature | WBsf219254 | ||||||
Experimental_info | RNAi_result (15) | ||||||
Expr_pattern (6) | |||||||
Drives_construct | WBCnstr00036540 | ||||||
Construct_product | WBCnstr00007295 | ||||||
WBCnstr00036540 | |||||||
Microarray_results (17) | |||||||
Expression_cluster (124) | |||||||
Interaction (228) | |||||||
WBProcess | WBbiopr:00000072 | ||||||
Map_info | Map | I | Position | -1.59708 | Error | 0.006668 | |
Positive | Positive_clone | C18E3 | Author_evidence | Li XJ | |||
Greenwald IS | |||||||
Inferred_automatically | From sequence, transcript, pseudogene data | ||||||
Mapping_data | Multi_point | 4412 | |||||
4507 | |||||||
Pseudo_map_position | |||||||
Reference (60) | |||||||
Remark | Data extracted from Li et al. (1997) | ||||||
Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | ||||||
Method | Gene |