WormBase Tree Display for Gene: WBGene00001985
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WBGene00001985 | SMap | S_parent | Sequence | C18E3 | |||||
---|---|---|---|---|---|---|---|---|---|
Identity | Version | 1 | |||||||
Name | CGC_name | hop-1 | Person_evidence | WBPerson220 | |||||
Sequence_name | C18E3.8 | ||||||||
Molecular_name | C18E3.8 | ||||||||
C18E3.8.1 | |||||||||
CE08317 | |||||||||
Other_name | CELE_C18E3.8 | Accession_evidence | NDB | BX284601 | |||||
Public_name | hop-1 | ||||||||
DB_info | Database (11) | ||||||||
Species | Caenorhabditis elegans | ||||||||
History | Version_change | 1 | 07 Apr 2004 11:29:26 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
Status | Live | ||||||||
Gene_info | Biotype | SO:0001217 | |||||||
Gene_class | hop | ||||||||
Allele (48) | |||||||||
Legacy_information | [Li X, Greenwald I] hop for Homolog Of Presenilin. No mutants known. hop-1(RNAi) has no obvious effect on WT, but leads to synthetic lethality in sel-12. Transgenic hop-1 rescues Egl phenotype of sel-12. Predicted gene C18E3.8 | ||||||||
Strain | WBStrain00004785 | ||||||||
WBStrain00008037 | |||||||||
RNASeq_FPKM (74) | |||||||||
GO_annotation (41) | |||||||||
Ortholog (23) | |||||||||
Paralog | WBGene00004769 | Caenorhabditis elegans | From_analysis | TreeFam | |||||
Panther | |||||||||
WormBase-Compara | |||||||||
WBGene00004958 | Caenorhabditis elegans | From_analysis | Panther | ||||||
WormBase-Compara | |||||||||
Structured_description | Concise_description | hop-1 encodes one of three C. elegans presenilins (the other two presenilins are encoded by sel-12 and spe-4); originally identified on the basis of its sequence similarity to SEL-12 and the human PS1 and PS2 presenilins, HOP-1 has been shown to function redundantly with SEL-12 in embryonic, larval, and germline development and thus, to likely function by regulating LIN-12/GLP-1 signaling; in addition, hop-1 can functionally substitute for sel-12 by rescuing the egg-laying and vulval development defects of sel-12 mutants; hop-1 transcription appears to be regulated, at least in part, by the C. elegans spr genes, some of which encode orthologs of the mammalian CoREST repressor complex. | Paper_evidence | WBPaper00002932 | |||||
WBPaper00003421 | |||||||||
WBPaper00005564 | |||||||||
Curator_confirmed | WBPerson1843 | ||||||||
Date_last_updated | 05 Mar 2008 00:00:00 | ||||||||
Automated_description | Predicted to enable endopeptidase activity. Involved in several processes, including egg-laying behavior; positive regulation of Notch signaling pathway; and regulation of vulval development. Predicted to be located in several cellular components, including apical plasma membrane; cytoplasm; and plasma membrane bounded cell projection. | Paper_evidence | WBPaper00065943 | ||||||
Curator_confirmed (2) | |||||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
Molecular_info | Corresponding_CDS | C18E3.8 | |||||||
Corresponding_transcript | C18E3.8.1 | ||||||||
Other_sequence | CRC04478_1 | ||||||||
CR03774 | |||||||||
Associated_feature | WBsf219254 | ||||||||
Experimental_info | RNAi_result (15) | ||||||||
Expr_pattern | Expr2273 | ||||||||
Expr1020822 | |||||||||
Expr1031154 | |||||||||
Expr1144989 | |||||||||
Expr2012537 | |||||||||
Expr2030776 | |||||||||
Drives_construct | WBCnstr00036540 | ||||||||
Construct_product | WBCnstr00007295 | ||||||||
WBCnstr00036540 | |||||||||
Microarray_results (17) | |||||||||
Expression_cluster (124) | |||||||||
Interaction (228) | |||||||||
WBProcess | WBbiopr:00000072 | ||||||||
Map_info | Map | I | Position | -1.59708 | Error | 0.006668 | |||
Positive | Positive_clone | C18E3 | Author_evidence | Li XJ | |||||
Greenwald IS | |||||||||
Inferred_automatically | From sequence, transcript, pseudogene data | ||||||||
Mapping_data | Multi_point (2) | ||||||||
Pseudo_map_position | |||||||||
Reference (60) | |||||||||
Remark | Data extracted from Li et al. (1997) | ||||||||
Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | ||||||||
Method | Gene |