WormBase Tree Display for Gene: WBGene00001851
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| WBGene00001851 | Evidence | CGC_data_submission | |||||||
|---|---|---|---|---|---|---|---|---|---|
| SMap | S_parent | Sequence | CHROMOSOME_V | ||||||
| Identity | Version | 1 | |||||||
| Name | CGC_name | hif-1 | Person_evidence | WBPerson496 | |||||
| Sequence_name | F38A6.3 | ||||||||
| Molecular_name (18) | |||||||||
| Other_name | CELE_F38A6.3 | Accession_evidence | NDB | BX284605 | |||||
| Public_name | hif-1 | ||||||||
| DB_info | Database (11) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:25 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | hif | ||||||||
| Allele (81) | |||||||||
| Strain (23) | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (34) | |||||||||
| Ortholog (49) | |||||||||
| Paralog | WBGene00000521 | Caenorhabditis elegans | From_analysis | Panther | |||||
| WormBase-Compara | |||||||||
| WBGene00011327 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| Structured_description | Concise_description | hif-1 encodes an ortholog of the mammalian hypoxia-induced factor HIF-1, and is required for survival in hypoxic environments (1% oxygen) that have no effect on wild-type C. elegans. | Paper_evidence | WBPaper00004762 | |||||
| Curator_confirmed | WBPerson567 | ||||||||
| Date_last_updated | 17 Jun 2004 00:00:00 | ||||||||
| Automated_description | Enables DNA-binding transcription factor activity and RNA polymerase II-specific DNA-binding transcription factor binding activity. Involved in several processes, including cellular response to caloric restriction; determination of adult lifespan; and heat acclimation. Located in nucleus. Expressed widely. Used to study cancer. Human ortholog(s) of this gene implicated in several diseases, including arthritis (multiple); familial erythrocytosis 4; and hypertension (multiple). Is an ortholog of human EPAS1 (endothelial PAS domain protein 1) and HIF3A (hypoxia inducible factor 3 subunit alpha). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Experimental_model | DOID:162 | Homo sapiens | Paper_evidence | WBPaper00036343 | ||||
| Curator_confirmed | WBPerson38202 | ||||||||
| Date_last_updated | 02 Jul 2018 00:00:00 | ||||||||
| Potential_model | DOID:7148 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:3374) | |||||
| DOID:3908 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:3374) | ||||||
| DOID:10591 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:3374) | ||||||
| DOID:8893 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:3374) | ||||||
| DOID:8432 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:3374) | ||||||
| DOID:8398 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:3374) | ||||||
| DOID:6432 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:3374) | ||||||
| DOID:14175 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:3374) | ||||||
| DOID:0080339 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:3374) | ||||||
| Models_disease_asserted | WBDOannot00000595 | ||||||||
| Molecular_info | Corresponding_CDS | F38A6.3a | |||||||
| F38A6.3b | |||||||||
| F38A6.3c | |||||||||
| F38A6.3d | |||||||||
| F38A6.3e | |||||||||
| F38A6.3f | |||||||||
| Corresponding_CDS_history | F38A6.3a:wp188 | ||||||||
| F38A6.3b:wp188 | |||||||||
| F38A6.3d:wp140 | |||||||||
| F38A6.3e:wp188 | |||||||||
| Corresponding_transcript | F38A6.3a.1 | ||||||||
| F38A6.3b.1 | |||||||||
| F38A6.3c.1 | |||||||||
| F38A6.3d.1 | |||||||||
| F38A6.3e.1 | |||||||||
| F38A6.3f.1 | |||||||||
| Other_sequence (34) | |||||||||
| Associated_feature | WBsf647762 | ||||||||
| WBsf647763 | |||||||||
| WBsf661080 | |||||||||
| WBsf982096 | |||||||||
| WBsf1003642 | |||||||||
| WBsf1003643 | |||||||||
| WBsf1003644 | |||||||||
| WBsf1003645 | |||||||||
| WBsf1022012 | |||||||||
| WBsf1022013 | |||||||||
| Gene_product_binds | WBsf919675 | ||||||||
| WBsf919676 | |||||||||
| WBsf919677 | |||||||||
| WBsf919681 | |||||||||
| WBsf919682 | |||||||||
| WBsf919683 | |||||||||
| Transcription_factor | WBTranscriptionFactor000728 | ||||||||
| Experimental_info | RNAi_result (53) | ||||||||
| Expr_pattern | Expr1246 | ||||||||
| Expr1020261 | |||||||||
| Expr1031087 | |||||||||
| Expr1150556 | |||||||||
| Expr2012413 | |||||||||
| Expr2030649 | |||||||||
| Drives_construct (12) | |||||||||
| Construct_product (28) | |||||||||
| Regulate_expr_cluster | WBPaper00055941:hif-1(ia4)_downregulated | ||||||||
| WBPaper00055941:hif-1(ia4)_upregulated | |||||||||
| Antibody | WBAntibody00000413 | ||||||||
| WBAntibody00002054 | |||||||||
| WBAntibody00002195 | |||||||||
| Microarray_results (45) | |||||||||
| Expression_cluster (150) | |||||||||
| Interaction (145) | |||||||||
| WBProcess | WBbiopr:00000008 | ||||||||
| WBbiopr:00000054 | |||||||||
| WBbiopr:00000096 | |||||||||
| Map_info | Map | V | Position | 25.1977 | Error | 0.022563 | |||
| Positive | Positive_clone | F38A6 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Mapping_data | Multi_point | 4283 | |||||||
| 4401 | |||||||||
| 4651 | |||||||||
| Pseudo_map_position | |||||||||
| Reference (218) | |||||||||
| Remark | Sequence connection from [Powell-Coffman JA] | ||||||||
| Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | ||||||||
| Method | Gene |
