WormBase Tree Display for Gene: WBGene00001680
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WBGene00001680 | SMap | S_parent | Sequence | F52A8 | |||
---|---|---|---|---|---|---|---|
Identity (6) | |||||||
Gene_info | Biotype | SO:0001217 | |||||
Gene_class | gpb | ||||||
Allele (47) | |||||||
Legacy_information | [Leon Avery] Weak Eat: slippery corpus. Slightly long. Movement slightly loopy (i.e. bends are deeper than normal). Hypersensitive to arecoline: will not grown at concentrations >= 1 mM. | ||||||
See also ad541 | |||||||
[C.elegansII] ad541 : weak Eat: slippery corpus. Slightly long. Movement slightly loopy (i.e. bends are deeper than normal). Hypersensitive to arecoline (cholinergic agonist): will not grown at concentrations >= 1 mM. Synthetic lethal with eat-6; suppressed by egl-30(gf), exp-2(gf). NA1. [Avery 1993; DA; JT] | |||||||
[M Robatzek] eat-11 is allelic to gpb-2 (Robatzek et al. Current Biology 2001, 11:288-293) | |||||||
Strain | WBStrain00028988 | ||||||
WBStrain00029004 | |||||||
WBStrain00022804 | |||||||
WBStrain00028986 | |||||||
WBStrain00037676 | |||||||
WBStrain00005480 | |||||||
WBStrain00005517 | |||||||
RNASeq_FPKM (74) | |||||||
GO_annotation (20) | |||||||
Ortholog (39) | |||||||
Paralog | WBGene00001679 | Caenorhabditis elegans | From_analysis | Panther | |||
WormBase-Compara | |||||||
Structured_description | Concise_description | gpb-2 encodes an ortholog of Gbeta(5), that is dispensable for viability, but required for normal egg-laying, locomotion, and pharyngeal pumping; GBP-2 may regulate the interaction between the GOA-1 and EGL-30 signaling pathways based on genetic analysis; gpb-2 is expressed throughout development in the nervous system and in muscle, and expression is dependent upon expression of both EAT-16 and EGL-10. | Paper_evidence | WBPaper00002466 | |||
WBPaper00004406 | |||||||
WBPaper00004687 | |||||||
WBPaper00004713 | |||||||
WBPaper00004714 | |||||||
WBPaper00014715 | |||||||
WBPaper00015075 | |||||||
WBPaper00015719 | |||||||
WBPaper00016788 | |||||||
Curator_confirmed | WBPerson48 | ||||||
WBPerson567 | |||||||
Date_last_updated | 17 Jun 2004 00:00:00 | ||||||
Automated_description | Predicted to enable signaling receptor complex adaptor activity. Involved in several processes, including cellular response to organonitrogen compound; regulation of egg-laying behavior; and regulation of pharyngeal pumping. Located in neuronal cell body. Expressed in body wall musculature; neurons; pharyngeal muscle cell; and vulval muscle. Human ortholog(s) of this gene implicated in intellectual developmental disorder with cardiac arrhythmia. Is an ortholog of human GNB5 (G protein subunit beta 5). | Paper_evidence | WBPaper00065943 | ||||
Curator_confirmed | WBPerson324 | ||||||
WBPerson37462 | |||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||
Disease_info | Potential_model | DOID:0081008 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:4401) | ||
Molecular_info | Corresponding_CDS | F52A8.2a | |||||
Corresponding_CDS_history | F52A8.2:wp246 | ||||||
Corresponding_transcript | F52A8.2b | ||||||
F52A8.2a.1 | |||||||
Other_sequence (82) | |||||||
Associated_feature | WBsf984145 | ||||||
WBsf984146 | |||||||
WBsf1010061 | |||||||
WBsf1010062 | |||||||
WBsf219742 | |||||||
WBsf219743 | |||||||
WBsf219744 | |||||||
Experimental_info | RNAi_result | WBRNAi00047906 | Inferred_automatically | RNAi_primary | |||
WBRNAi00089830 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00032572 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00116830 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00063514 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00090194 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00089876 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00090035 | Inferred_automatically | RNAi_primary | |||||
Expr_pattern | Expr1344 | ||||||
Expr1360 | |||||||
Expr1020669 | |||||||
Expr1031001 | |||||||
Expr1151735 | |||||||
Expr2012200 | |||||||
Expr2030436 | |||||||
Drives_construct | WBCnstr00000572 | ||||||
WBCnstr00001696 | |||||||
WBCnstr00001704 | |||||||
WBCnstr00022812 | |||||||
WBCnstr00036776 | |||||||
Construct_product | WBCnstr00001696 | ||||||
WBCnstr00036776 | |||||||
Antibody | WBAntibody00000370 | ||||||
Microarray_results (19) | |||||||
Expression_cluster (149) | |||||||
Interaction (64) | |||||||
Map_info | Map | I | Position | 1.91015 | Error | 0.005018 | |
Well_ordered | |||||||
Positive | Positive_clone | F52A8 | Inferred_automatically | From sequence, transcript, pseudogene data | |||
R02H7 | |||||||
Negative | Negative_clone | F07A5 | |||||
Mapping_data (3) | |||||||
Reference (70) | |||||||
Remark | Interacting_genes '[Leon Avery] eat-6: Lethal or subviable in double mutants with eat-6. | ||||||
Interacting_genes '[Leon Avery] egl-30: Suppressed by egl-30(gf) mutations. | |||||||
Method | Gene |