WormBase Tree Display for Gene: WBGene00001527
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| WBGene00001527 | SMap | S_parent | Sequence | F37B12 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | gcs-1 | Person_evidence | WBPerson1787 | |||||
| Sequence_name | F37B12.2 | ||||||||
| Molecular_name | F37B12.2 | ||||||||
| F37B12.2.1 | |||||||||
| CE32886 | |||||||||
| Other_name | CELE_F37B12.2 | Accession_evidence | NDB | BX284602 | |||||
| Public_name | gcs-1 | ||||||||
| DB_info | Database (13) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:24 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | gcs | ||||||||
| Allele (36) | |||||||||
| Strain | WBStrain00035689 | ||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (22) | |||||||||
| Contained_in_operon | CEOP2408 | ||||||||
| Ortholog (38) | |||||||||
| Structured_description | Concise_description | gcs-1 encodes the C. elegans ortholog of gamma-glutamine cysteine synthetase heavy chain (GCS(h)); GCS-1 is predicted to function, in a conserved oxidative stress response pathway, as a phase II detoxification enzyme that catalyzes the rate-limiting first step in glutathione biosynthesis; a GCS-1::GFP reporter fusion is expressed in larvae and adults in the pharynx, ASI chemosensory neurons, and anterior and posterior intestine and upon exposure to oxidative stress, such as heat or herbicide, the intestinal expression increases dramatically; constitutive and stress-inducible GCS-1::GFP expression in the ASI neurons and intestine, respectively, is under the control of the SKN-1 CNC transcription factor; loss of gcs-1 activity via RNAi results in a low percentage of larval lethality and intestinal abnormalities suggesting that gcs-1 plays a role in postembryonic development. | Paper_evidence | WBPaper00006024 | |||||
| Curator_confirmed | WBPerson1843 | ||||||||
| WBPerson1823 | |||||||||
| WBPerson567 | |||||||||
| Date_last_updated | 09 Dec 2005 00:00:00 | ||||||||
| Automated_description | Predicted to enable glutamate-cysteine ligase activity. Involved in several processes, including glutathione biosynthetic process; response to arsenic-containing substance; and response to superoxide. Predicted to be part of glutamate-cysteine ligase complex. Expressed in ASIL; ASIR; intestine; and pharynx. Human ortholog(s) of this gene implicated in several diseases, including colorectal cancer; cystic fibrosis; and glutamate-cysteine ligase deficiency. Is an ortholog of human GCLC (glutamate-cysteine ligase catalytic subunit). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:9256 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:4311) | ||||
| DOID:1485 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:4311) | ||||||
| DOID:5844 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:4311) | ||||||
| DOID:583 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:4311) | ||||||
| DOID:0111681 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:4311) | ||||||
| Molecular_info | Corresponding_CDS | F37B12.2 | |||||||
| Corresponding_CDS_history | F37B12.2:wp92 | ||||||||
| Corresponding_transcript | F37B12.2.1 | ||||||||
| Other_sequence (45) | |||||||||
| Associated_feature | WBsf019114 | ||||||||
| WBsf019115 | |||||||||
| WBsf019116 | |||||||||
| WBsf650392 | |||||||||
| WBsf665885 | |||||||||
| WBsf665886 | |||||||||
| WBsf988911 | |||||||||
| WBsf988912 | |||||||||
| WBsf223588 | |||||||||
| WBsf223589 | |||||||||
| Experimental_info | RNAi_result (12) | ||||||||
| Expr_pattern | Expr2645 | ||||||||
| Expr1017947 | |||||||||
| Expr1030919 | |||||||||
| Expr1150470 | |||||||||
| Expr2011972 | |||||||||
| Expr2030209 | |||||||||
| Drives_construct | WBCnstr00005482 | ||||||||
| WBCnstr00008744 | |||||||||
| WBCnstr00008746 | |||||||||
| WBCnstr00008747 | |||||||||
| WBCnstr00008979 | |||||||||
| WBCnstr00010885 | |||||||||
| WBCnstr00015998 | |||||||||
| WBCnstr00019631 | |||||||||
| WBCnstr00036887 | |||||||||
| Construct_product | WBCnstr00036887 | ||||||||
| Microarray_results (19) | |||||||||
| Expression_cluster (115) | |||||||||
| Interaction (147) | |||||||||
| WBProcess | WBbiopr:00000065 | ||||||||
| Map_info | Map | II | Position | 0.990787 | Error | 0.004991 | |||
| Positive | Positive_clone | F37B12 | Inferred_automatically | From CDS info | |||||
| From sequence, transcript, pseudogene data | |||||||||
| Mapping_data | Multi_point | 4337 | |||||||
| 4858 | |||||||||
| 4825 | |||||||||
| 5491 | |||||||||
| Pseudo_map_position | |||||||||
| Reference (65) | |||||||||
| Picture | WBPicture0000013093 | ||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
