WormBase Tree Display for Gene: WBGene00001402
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WBGene00001402 | SMap | S_parent | Sequence | F21H12 | |||
---|---|---|---|---|---|---|---|
Identity (6) | |||||||
Gene_info | Biotype | SO:0001217 | |||||
Gene_class | fbf | ||||||
Allele (52) | |||||||
Legacy_information | [Gallegos M, Zhang B] fbf-2(RNAi) animals produce excess sperm and no oocytes (Mog phenotype). Encodes fem-3 PME RNA binding protein, 91% identical to FBF-1. Predicted gene F21H12.5 | ||||||
Strain | WBStrain00022611 | ||||||
WBStrain00022612 | |||||||
WBStrain00022628 | |||||||
WBStrain00022640 | |||||||
WBStrain00022665 | |||||||
WBStrain00022345 | |||||||
WBStrain00022394 | |||||||
WBStrain00022449 | |||||||
RNASeq_FPKM (74) | |||||||
GO_annotation (13) | |||||||
Ortholog (33) | |||||||
Paralog (9) | |||||||
Structured_description | Concise_description | fbf-2 encodes an RNA-binding protein that is one of 11 C. elegans members of the PUF family (Pumilio and FBF) of translational regulators; FBF-2 is nearly identical to FBF-1 with which it is largely redundant in regulating two aspects of germline development: 1)maintenance of stem cell proliferation, and 2)the hermaphroditic switch between spermatogenesis and oogenesis; in maintaining germline stem cells, the FBF proteins, acting through NOS-3, negatively regulate the activity of gld-1 mRNA, which encodes a translational repressor required for meiotic entry; in regulating the sperm-to-oocyte switch, the FBFs act downstream of GLD-3 to negatively regulate the activity of fem-3 mRNA, which encodes a novel protein required for germline sex determination; consistent with their role in germline development, FBF-1 and FBF-2 are expressed in the germline cytoplasm, becoming enriched in the mitotic region during the L4 larval and adult stages. | Paper_evidence | WBPaper00002949 | |||
WBPaper00005265 | |||||||
WBPaper00005566 | |||||||
WBPaper00006369 | |||||||
WBPaper00018711 | |||||||
Curator_confirmed | WBPerson1843 | ||||||
Date_last_updated | 24 Sep 2004 00:00:00 | ||||||
Automated_description | Enables mRNA 3'-UTR binding activity. Involved in negative regulation of translation. Located in P granule. Used to study obesity. | Paper_evidence | WBPaper00065943 | ||||
Curator_confirmed | WBPerson324 | ||||||
WBPerson37462 | |||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||
Disease_info | Experimental_model | DOID:9970 | Homo sapiens | Paper_evidence | WBPaper00061889 | ||
Curator_confirmed | WBPerson324 | ||||||
Date_last_updated | 28 Jun 2022 00:00:00 | ||||||
Models_disease_in_annotation | WBDOannot00001264 | ||||||
Molecular_info | Corresponding_CDS | F21H12.5 | |||||
Corresponding_transcript | F21H12.5.1 | ||||||
Other_sequence | EX544358.1 | ||||||
Oden_isotig19477 | |||||||
PP02603 | |||||||
PPC01861_1 | |||||||
EX564883.1 | |||||||
GW916430.1 | |||||||
CJC02888_1 | |||||||
Associated_feature | WBsf223129 | ||||||
Gene_product_binds | WBsf027922 | ||||||
WBsf899551 | |||||||
WBsf899552 | |||||||
WBsf899553 | |||||||
WBsf899554 | |||||||
Transcription_factor | WBTranscriptionFactor000103 | ||||||
Experimental_info | RNAi_result (70) | ||||||
Expr_pattern (12) | |||||||
Drives_construct | WBCnstr00005290 | ||||||
WBCnstr00036968 | |||||||
Construct_product | WBCnstr00005274 | ||||||
WBCnstr00015117 | |||||||
WBCnstr00036968 | |||||||
WBCnstr00040359 | |||||||
Regulate_expr_cluster | WBPaper00055804:FBF-1-FBF-2-associated_oogenic-enriched | ||||||
WBPaper00055804:FBF-1-FBF-2-associated_spermatogenic-enriched | |||||||
Antibody | WBAntibody00000785 | ||||||
WBAntibody00000965 | |||||||
WBAntibody00001086 | |||||||
Microarray_results (16) | |||||||
Expression_cluster (117) | |||||||
Interaction (93) | |||||||
Map_info | Map | II | Position | -0.523905 | Error | 0.013695 | |
Positive | Positive_clone | F21H12 | Author_evidence | (genome sequence, | |||
Inferred_automatically | From sequence, transcript, pseudogene data | ||||||
Mapping_data | Multi_point | 4304 | |||||
4305 | |||||||
4907 | |||||||
Pseudo_map_position | |||||||
Reference (136) | |||||||
Picture | WBPicture0000013095 | ||||||
Remark | Data extracted from Zhang et al. (1997) | ||||||
Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | ||||||
Method | Gene |