WormBase Tree Display for Gene: WBGene00001008
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| WBGene00001008 | SMap | S_parent | Sequence | CHROMOSOME_I | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | dlk-1 | Person_evidence | WBPerson1315 | |||||
| Sequence_name | F33E2.2 | ||||||||
| Molecular_name (15) | |||||||||
| Other_name | CELE_F33E2.2 | Accession_evidence | NDB | BX284601 | |||||
| Public_name | dlk-1 | ||||||||
| DB_info | Database (14) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:22 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | dlk | ||||||||
| Allele (159) | |||||||||
| Strain | WBStrain00005397 | ||||||||
| WBStrain00024036 | |||||||||
| WBStrain00005411 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (52) | |||||||||
| Ortholog (42) | |||||||||
| Paralog (11) | |||||||||
| Structured_description | Concise_description | dlk-1 encodes a mitogen-activated protein kinase kinase kinase (MAPKKK) that is the C. elegans ortholog of the dual-leucine zipper MAPKKK; in C. elegans, dlk-1 functions with mkk-4 and pmk-3 in a MAPK signaling pathway that regulates presynaptic development; dlk-1 is also essential for neuron regeneration; DLK-1 abundance is negatively regulated by the RPM-1 E3 ubiquitin ligase which can stimulate DLK-1 ubiquitination; DLK-1 localizes to the periactive zone of synapses in the nerve ring and nerve cord. | Paper_evidence | WBPaper00024955 | |||||
| WBPaper00031466 | |||||||||
| WBPaper00032505 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| WBPerson567 | |||||||||
| Date_last_updated | 21 Mar 2011 00:00:00 | ||||||||
| Automated_description | Enables ubiquitin protein ligase binding activity. Involved in several processes, including cellular component organization; p38MAPK cascade; and regulation of 3'-UTR-mediated mRNA stabilization. Located in neuronal cell body and synapse. Expressed in PLML and PLMR. Is an ortholog of human MAP3K12 (mitogen-activated protein kinase kinase kinase 12). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Molecular_info | Corresponding_CDS | F33E2.2a | |||||||
| F33E2.2b | |||||||||
| F33E2.2c | |||||||||
| F33E2.2d | |||||||||
| F33E2.2e | |||||||||
| Corresponding_CDS_history | F33E2.2:wp114 | ||||||||
| Corresponding_transcript | F33E2.2a.1 | ||||||||
| F33E2.2b.1 | |||||||||
| F33E2.2c.1 | |||||||||
| F33E2.2d.1 | |||||||||
| F33E2.2e.1 | |||||||||
| Other_sequence (19) | |||||||||
| Associated_feature (23) | |||||||||
| Experimental_info | RNAi_result | WBRNAi00113106 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00075937 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00113201 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00031721 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00046215 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00112971 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00003207 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00113159 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00003576 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00091030 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern | Expr8637 | ||||||||
| Expr8644 | |||||||||
| Expr12042 | |||||||||
| Expr12623 | |||||||||
| Expr16462 | |||||||||
| Expr1015860 | |||||||||
| Expr1030629 | |||||||||
| Expr1150102 | |||||||||
| Expr2010950 | |||||||||
| Expr2029189 | |||||||||
| Drives_construct | WBCnstr00000739 | ||||||||
| WBCnstr00000740 | |||||||||
| WBCnstr00020129 | |||||||||
| WBCnstr00037143 | |||||||||
| Construct_product | WBCnstr00006402 | ||||||||
| WBCnstr00013415 | |||||||||
| WBCnstr00014764 | |||||||||
| WBCnstr00015118 | |||||||||
| WBCnstr00015610 | |||||||||
| WBCnstr00018875 | |||||||||
| WBCnstr00022304 | |||||||||
| WBCnstr00037143 | |||||||||
| WBCnstr00038069 | |||||||||
| WBCnstr00039781 | |||||||||
| Regulate_expr_cluster | WBPaper00059604:dlk-1(km12)_downregulated | ||||||||
| WBPaper00059604:dlk-1(km12)_upregulated | |||||||||
| Microarray_results (31) | |||||||||
| Expression_cluster (184) | |||||||||
| Interaction (63) | |||||||||
| WBProcess | WBbiopr:00000117 | ||||||||
| Map_info | Map | I | Position | 13.6067 | Error | 0.020734 | |||
| Positive | Positive_clone | F33E2 | Inferred_automatically | From CDS info | |||||
| From sequence, transcript, pseudogene data | |||||||||
| Mapping_data | Multi_point | 4262 | |||||||
| Pseudo_map_position | |||||||||
| Reference (120) | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
