WormBase Tree Display for Gene: WBGene00000879
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WBGene00000879 | SMap | S_parent | Sequence | Y75B12B | |||
---|---|---|---|---|---|---|---|
Identity | Version | 2 | |||||
Name | CGC_name | cyn-3 | Person_evidence | WBPerson466 | |||
Sequence_name | Y75B12B.5 | ||||||
Molecular_name | Y75B12B.5 | ||||||
Y75B12B.5.1 | |||||||
CE20374 | |||||||
Other_name | cyp-3 | Person_evidence | WBPerson466 | ||||
CELE_Y75B12B.5 | Accession_evidence | NDB | BX284605 | ||||
Public_name | cyn-3 | ||||||
DB_info | Database (12) | ||||||
Species | Caenorhabditis elegans | ||||||
History | Version_change (2) | ||||||
Status | Live | ||||||
Gene_info | Biotype | SO:0001217 | |||||
Gene_class | cyn | ||||||
Allele (28) | |||||||
Legacy_information | [C.elegansII] NMK. Cyclophilin family, transspliced to SL1. YAC Y15F7. [TP] | ||||||
RNASeq_FPKM (74) | |||||||
GO_annotation (15) | |||||||
Contained_in_operon | CEOP5521 | ||||||
Ortholog (54) | |||||||
Paralog (18) | |||||||
Structured_description | Concise_description | cyn-3 encodes an abundantly expressed cyclophilin A isoform with peptidyl-prolyl isomerase activity in vitro, which closely resembles the prototypical CypA and is thus likely to be a member of the cytosolic CsA-binding cyclophilin subfamily; cyn-3 is exclusively expressed in the single anterior excretory cell, and is dispensable for viability and gross morphology in mass RNAi screens. | Paper_evidence | WBPaper00002472 | |||
WBPaper00003820 | |||||||
WBPaper00005654 | |||||||
WBPaper00026884 | |||||||
Curator_confirmed | WBPerson1843 | ||||||
WBPerson567 | |||||||
Date_last_updated | 20 Mar 2007 00:00:00 | ||||||
Automated_description | Enables peptidyl-prolyl cis-trans isomerase activity. Predicted to be involved in protein folding. Located in obsolete cell. Expressed in excretory system. Human ortholog(s) of this gene implicated in several diseases, including Bell's palsy; aggressive periodontitis; and gastrointestinal system cancer (multiple). Is an ortholog of human PPIA (peptidylprolyl isomerase A); PPIAL4C (peptidylprolyl isomerase A like 4C); and PPIF (peptidylprolyl isomerase F). | Paper_evidence | WBPaper00065943 | ||||
Curator_confirmed | WBPerson324 | ||||||
WBPerson37462 | |||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||
Disease_info | Potential_model | DOID:4947 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:9253) | ||
DOID:9261 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:9253) | ||||
DOID:1474 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:9253) | ||||
DOID:526 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:9253) | ||||
DOID:12506 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:9253) | ||||
Molecular_info | Corresponding_CDS | Y75B12B.5 | |||||
Corresponding_transcript | Y75B12B.5.1 | ||||||
Other_sequence (202) | |||||||
Associated_feature | WBsf647585 | ||||||
WBsf977375 | |||||||
WBsf977376 | |||||||
WBsf1002255 | |||||||
WBsf1002256 | |||||||
WBsf1020992 | |||||||
WBsf233011 | |||||||
Experimental_info | RNAi_result | WBRNAi00076847 | Inferred_automatically | RNAi_primary | |||
WBRNAi00021430 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00058423 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00027819 | Inferred_automatically | RNAi_primary | |||||
Expr_pattern | Expr984 | ||||||
Expr985 | |||||||
Expr1018223 | |||||||
Expr1030544 | |||||||
Expr1161844 | |||||||
Expr2010671 | |||||||
Expr2028911 | |||||||
Drives_construct | WBCnstr00013833 | ||||||
WBCnstr00037227 | |||||||
Construct_product (2) | |||||||
Microarray_results (23) | |||||||
Expression_cluster (127) | |||||||
Interaction (105) | |||||||
Map_info | Map | V | Position | 7.54862 | Error | 0.006411 | |
Positive | Positive_clone | Y15F7 | Author_evidence | Page AM | |||
Y75B12B | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
ZK526 | |||||||
Pseudo_map_position | |||||||
Reference | WBPaper00002472 | ||||||
WBPaper00003820 | |||||||
WBPaper00018604 | |||||||
WBPaper00026884 | |||||||
WBPaper00032230 | |||||||
WBPaper00038491 | |||||||
WBPaper00041771 | |||||||
WBPaper00049828 | |||||||
WBPaper00055090 | |||||||
Remark | [Page AM] Is transpliced by SL-1. Isolated from mixed stage cDNA by A. P. Page using SL1, and known 3' seq from CEESH95F. (not mapped); Genbank U31077. | ||||||
[JAH]Partial sequence identity 64% to human CYP gene, 66% to yeast CSBY. | |||||||
CEESH95F,CEMSB85F,CEMSB85FB,CEMSB85R removed from sequence list and replaced by genomic_canonical Y75B12B.5. sdm 11/00 | |||||||
PPIase or cyclophilin, EC 5.2.1.8 | |||||||
This gene has been renamed with approval of the CGC (cyp-3->cyn-3) | Person_evidence | WBPerson466 | |||||
Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | ||||||
Method | Gene |