WormBase Tree Display for Gene: WBGene00000832
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WBGene00000832 | SMap | S_parent | Sequence | Y23H5A | |||
---|---|---|---|---|---|---|---|
Identity (6) | |||||||
Gene_info | Biotype | SO:0001217 | |||||
Gene_class | ctn | ||||||
Allele (245) | |||||||
Strain | WBStrain00037343 | ||||||
RNASeq_FPKM (74) | |||||||
GO_annotation | 00021143 | ||||||
00021144 | |||||||
00021145 | |||||||
00021146 | |||||||
00021147 | |||||||
00021148 | |||||||
00107861 | |||||||
00107862 | |||||||
00107863 | |||||||
00107864 | |||||||
Ortholog (35) | |||||||
Paralog | WBGene00000942 | Caenorhabditis elegans | From_analysis | TreeFam | |||
WormBase-Compara | |||||||
WBGene00001978 | Caenorhabditis elegans | From_analysis | TreeFam | ||||
WormBase-Compara | |||||||
Structured_description | Concise_description | ctn-1 encodes a protein that belongs to the alpha-catulin family of catenin-like proteins; CTN-1 physically interacts in vivo with DYB-1/dystrobrevin; a ctn-1::GFP fusion is expressed in body wall, vulval, and anal muscles; in body wall muscles, CTN-1::GFP localizes to the plasma membranes near dense bodies. | Paper_evidence | WBPaper00011358 | |||
WBPaper00041089 | |||||||
Curator_confirmed (2) | |||||||
Date_last_updated | 02 Aug 2012 00:00:00 | ||||||
Automated_description | Predicted to enable actin filament binding activity and cadherin binding activity. Involved in regulation of locomotion. Located in plasma membrane and striated muscle dense body. Expressed in body wall musculature; non-striated muscle; and somatic nervous system. Used to study Duchenne muscular dystrophy. Is an ortholog of human CTNNAL1 (catenin alpha like 1). | Paper_evidence | WBPaper00065943 | ||||
Curator_confirmed (2) | |||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||
Disease_info | Experimental_model | DOID:11723 | Homo sapiens | Paper_evidence | WBPaper00037625 | ||
Accession_evidence | OMIM | 310200 | |||||
Curator_confirmed | WBPerson324 | ||||||
Date_last_updated | 22 May 2017 00:00:00 | ||||||
Disease_relevance | Mutations in human dystrophin are associated with the Duchenne and Becker types of muscular dystrophy, that affect skeletal muscles used for movement, and heart (cardiac) muscle; a number of transmembrane and peripheral membrane proteins interact with dystrophin to form the dystrophin-associated protein complex (DAPC); defects in components of the DAPC are associated with a variety of pathological conditions, including muscular dystrophy, cardiomyopathy, myoclonic dystonia, and vasospasm; in C. elegans, the DAPC localizes near dense bodies, structures that are analogous to muscle costameres; ctn-1, an ortholog of alpha catulin (catenin-like protein), interacts with dyb-1/dystrobrevin, and this interaction is required for the normal localization of the DAPC as well as for the slo-1 voltage- and calcium-activated potassium (BK) channel, in C. elegans muscle; in the dystrophic mdx mice, there is compensatory increase of alpha-catulin expression in the skeletal muscle where the DAPC is disassembled, and the mechanical link between the muscle costamere and the sarcolemma is lost. | Homo sapiens | Paper_evidence | WBPaper00037625 | |||
Curator_confirmed | WBPerson324 | ||||||
Date_last_updated | 22 May 2017 00:00:00 | ||||||
Models_disease_asserted | WBDOannot00000293 | ||||||
Molecular_info | Corresponding_CDS | Y23H5A.5a | |||||
Y23H5A.5c | |||||||
Y23H5A.5d | |||||||
Corresponding_CDS_history | Y23H5A.5a:wp274 | ||||||
Y23H5A.5b:wp274 | |||||||
Y23H5A.5c:wp228 | |||||||
Y23H5A.5d:wp210 | |||||||
Y23H5A.5d:wp228 | |||||||
Corresponding_transcript | Y23H5A.5e | ||||||
Y23H5A.5a.1 | |||||||
Y23H5A.5c.1 | |||||||
Y23H5A.5d.1 | |||||||
Y23H5A.5d.2 | |||||||
Y23H5A.5d.3 | |||||||
Other_sequence (47) | |||||||
Associated_feature (5) | |||||||
Experimental_info | RNAi_result | WBRNAi00002350 | Inferred_automatically | RNAi_primary | |||
WBRNAi00055702 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00055701 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00116607 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00004565 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00022472 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00036720 | Inferred_automatically | RNAi_primary | |||||
Expr_pattern (11) | |||||||
Drives_construct | WBCnstr00008299 | ||||||
WBCnstr00008300 | |||||||
WBCnstr00013721 | |||||||
WBCnstr00013723 | |||||||
WBCnstr00018330 | |||||||
WBCnstr00037258 | |||||||
Construct_product | WBCnstr00008299 | ||||||
WBCnstr00008300 | |||||||
WBCnstr00008301 | |||||||
WBCnstr00008302 | |||||||
WBCnstr00013723 | |||||||
WBCnstr00013724 | |||||||
WBCnstr00018330 | |||||||
WBCnstr00020433 | |||||||
WBCnstr00037258 | |||||||
Microarray_results (51) | |||||||
Expression_cluster (177) | |||||||
Interaction (29) | |||||||
Map_info | Map | I | Position | -8.18787 | Error | 0.026165 | |
Positive | Positive_clone | Y23H5A | Inferred_automatically | From CDS info | |||
From sequence, transcript, pseudogene data | |||||||
Pseudo_map_position | |||||||
Reference | WBPaper00011358 | ||||||
WBPaper00036762 | |||||||
WBPaper00037625 | |||||||
WBPaper00038491 | |||||||
WBPaper00039233 | |||||||
WBPaper00041089 | |||||||
WBPaper00043421 | |||||||
WBPaper00046703 | |||||||
WBPaper00055090 | |||||||
WBPaper00065040 | |||||||
Remark | Sequence connection from [Broadbent ID], 02/06/12 krb. | ||||||
Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | ||||||
Method | Gene |