WormBase Tree Display for Gene: WBGene00000565
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| WBGene00000565 | Evidence | Accession_evidence | EMBL | AJ132698 | |||||
|---|---|---|---|---|---|---|---|---|---|
| AJ132699 | |||||||||
| SMap | S_parent | Sequence | Y17G7B | ||||||
| Identity | Version | 2 | |||||||
| Name | CGC_name | cnt-1 | |||||||
| Sequence_name | Y17G7B.15 | ||||||||
| Molecular_name (12) | |||||||||
| Other_name | cnt-1A | Accession_evidence | EMBL | AJ132698 | |||||
| cnt-1B | Accession_evidence | EMBL | AJ132699 | ||||||
| cps-2 | Paper_evidence | WBPaper00045987 | |||||||
| CELE_Y17G7B.15 | Accession_evidence | NDB | BX284602 | ||||||
| Public_name | cnt-1 | ||||||||
| DB_info | Database (11) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:21 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| 2 | 10 Dec 2014 10:20:36 | WBPerson2970 | Name_change | Other_name | cps-2 | ||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | cnt | ||||||||
| Allele (598) | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (33) | |||||||||
| Ortholog (48) | |||||||||
| Paralog | WBGene00000566 | Caenorhabditis elegans | From_analysis | WormBase-Compara | |||||
| WBGene00008805 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| WBGene00010500 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| WBGene00012359 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| WBGene00017217 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| WBGene00017760 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| Structured_description | Concise_description | cnt-1 encodes a homolog of centaurin beta, an Arf GTPase activating protein (Arf GAP) that also contains a pleckstrin homology domain and C-terminal ankyrin repeats; by homology, CNT-1 is predicted to function as an Arf GAP that stimulates Arf GTPase activity and links cell signaling with cytoskeletal rearrangements and membrane trafficking; however, as loss of cnt-1 activity via large-scale RNAi screens does not result in any obvious abnormalities, the precise role of cnt-1 in C. elegans development and/or behavior is not yet known; cnt-1 is broadly expressed, being detected in the pharynx, excretory cell, spermatheca, distal tip cells of the gonad, neurons of the head and nerve ring, and anal epithelial cells; CNT-1 is able to bind the phosphoinositides PIP2 and PIP3 and upon production of PIP3, can translocate from the cytoplasm to the membrane. | Paper_evidence | WBPaper00005654 | |||||
| WBPaper00005655 | |||||||||
| WBPaper00011327 | |||||||||
| WBPaper00011676 | |||||||||
| WBPaper00023203 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 17 Jun 2004 00:00:00 | ||||||||
| Automated_description | Enables phosphatidylinositol phosphate binding activity and small GTPase binding activity. Involved in apoptotic process; negative regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process; and positive regulation of endosome to plasma membrane protein transport. Located in basolateral plasma membrane; cytoplasmic side of apical plasma membrane; and endosome membrane. Used to study cancer. Is an ortholog of human ACAP1 (ArfGAP with coiled-coil, ankyrin repeat and PH domains 1); ACAP2 (ArfGAP with coiled-coil, ankyrin repeat and PH domains 2); and ACAP3 (ArfGAP with coiled-coil, ankyrin repeat and PH domains 3). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Experimental_model | DOID:162 | Homo sapiens | Paper_evidence | WBPaper00046697 | ||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 15 Jul 2015 00:00:00 | ||||||||
| Models_disease_in_annotation | WBDOannot00000354 | ||||||||
| Molecular_info | Corresponding_CDS | Y17G7B.15a | |||||||
| Y17G7B.15b | |||||||||
| Y17G7B.15c | |||||||||
| Y17G7B.15d | |||||||||
| Corresponding_transcript | Y17G7B.15a.1 | ||||||||
| Y17G7B.15b.1 | |||||||||
| Y17G7B.15c.1 | |||||||||
| Y17G7B.15d.1 | |||||||||
| Other_sequence (38) | |||||||||
| Associated_feature | WBsf666223 | ||||||||
| WBsf666224 | |||||||||
| WBsf666225 | |||||||||
| WBsf990002 | |||||||||
| WBsf990003 | |||||||||
| WBsf990004 | |||||||||
| WBsf1013383 | |||||||||
| WBsf224030 | |||||||||
| Experimental_info | RNAi_result (17) | ||||||||
| Expr_pattern | Expr10541 | ||||||||
| Expr12067 | |||||||||
| Expr1023574 | |||||||||
| Expr1030341 | |||||||||
| Expr1159079 | |||||||||
| Expr2010284 | |||||||||
| Expr2028526 | |||||||||
| Drives_construct | WBCnstr00015750 | ||||||||
| Construct_product | WBCnstr00014846 | ||||||||
| WBCnstr00014847 | |||||||||
| WBCnstr00015750 | |||||||||
| Antibody | WBAntibody00002574 | ||||||||
| Microarray_results (30) | |||||||||
| Expression_cluster (87) | |||||||||
| Interaction (28) | |||||||||
| Map_info | Map | II | Position | 6.45814 | Error | 0.096169 | |||
| Positive | Positive_clone | Y17G7B | Inferred_automatically | From CDS info | |||||
| From sequence, transcript, pseudogene data | |||||||||
| Pseudo_map_position | |||||||||
| Reference (16) | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
