WormBase Tree Display for Gene: WBGene00000546
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| WBGene00000546 | SMap | S_parent | Sequence | Y77E11A | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 2 | |||||||
| Name | CGC_name | clp-6 | Person_evidence | WBPerson349 | |||||
| Sequence_name | Y77E11A.10 | ||||||||
| Molecular_name | Y77E11A.10 | ||||||||
| Y77E11A.10.1 | |||||||||
| CE48968 | |||||||||
| Other_name | CELE_Y77E11A.10 | Accession_evidence | NDB | BX284604 | |||||
| Public_name | clp-6 | ||||||||
| DB_info | Database | AceView | gene | 4C192 | |||||
| WormQTL | gene | WBGene00000546 | |||||||
| WormFlux | gene | WBGene00000546 | |||||||
| NDB | locus_tag | CELE_Y77E11A.10 | |||||||
| Panther | gene | CAEEL|WormBase=WBGene00000546|UniProtKB=Q9N4B2 | |||||||
| family | PTHR10183 | ||||||||
| NCBI | gene | 190738 | |||||||
| RefSeq | protein | NM_067680.3 | |||||||
| TrEMBL | UniProtAcc | Q9N4B2 | |||||||
| UniProt_GCRP | UniProtAcc | Q9N4B2 | |||||||
| OMIM | gene | 114220 | |||||||
| 114240 | |||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:21 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| 2 | 04 Sep 2013 14:15:17 | WBPerson4025 | Event | Split_into | WBGene00235267 | ||||
| Split_into | WBGene00235267 | ||||||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | clp | ||||||||
| Allele (137) | |||||||||
| Strain | WBStrain00032206 | ||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (12) | |||||||||
| Ortholog (47) | |||||||||
| Paralog (13) | |||||||||
| Structured_description | Concise_description | clp-6 encodes a calpain homolog that has significant identity to mammalian calpains over its whole length and that contains motifs typical of calpains, including a thiol (cysteine) protease active site and a Ca[2+]-binding domain; CLP-6 is not required for degenerative (necrotic-like) cell death in neurons induced by mutations such as mec-4(d), deg-3(d), or gsa-1(gf), since clp-6(RNAi) has no effect on such degeneration. | Paper_evidence | WBPaper00001111 | |||||
| WBPaper00023862 | |||||||||
| Curator_confirmed | WBPerson567 | ||||||||
| Date_last_updated | 30 Jul 2004 00:00:00 | ||||||||
| Automated_description | Predicted to enable calcium-dependent cysteine-type endopeptidase activity. Predicted to be involved in proteolysis. Predicted to be located in cytoplasm. Expressed in hypodermis. Human ortholog(s) of this gene implicated in Alzheimer's disease; autosomal dominant limb-girdle muscular dystrophy; autosomal recessive limb-girdle muscular dystrophy type 2A; hereditary spastic paraplegia 76; and stomach cancer. Is an ortholog of several human genes including CAPN1 (calpain 1); CAPN2 (calpain 2); and CAPN3 (calpain 3). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:10652 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:1476,HGNC:1479) | ||||
| DOID:0110275 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:1480) | ||||||
| DOID:0110273 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:1480) | ||||||
| DOID:9884 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:1480) | ||||||
| DOID:10534 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:1486) | ||||||
| DOID:0110821 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:1476) | ||||||
| Molecular_info | Corresponding_CDS | Y77E11A.10 | |||||||
| Corresponding_CDS_history | Y77E11A.10:wp239 | ||||||||
| Corresponding_transcript | Y77E11A.10.1 | ||||||||
| Associated_feature | WBsf667660 | ||||||||
| WBsf667741 | |||||||||
| WBsf995439 | |||||||||
| WBsf1016726 | |||||||||
| WBsf229765 | |||||||||
| Experimental_info | RNAi_result (13) | ||||||||
| Expr_pattern | Expr10021 | ||||||||
| Expr1010393 | |||||||||
| Expr1030327 | |||||||||
| Expr1161915 | |||||||||
| Expr2010247 | |||||||||
| Expr2028489 | |||||||||
| Drives_construct | WBCnstr00014648 | ||||||||
| Microarray_results | SMD_Y77E11A_3443.M | ||||||||
| 187231_at | |||||||||
| GPL14144_Y77E11A.10_1293-1352_0.872_53_C | |||||||||
| GPL14144_Y77E11A.10_1580-1639_0.855_73_B | |||||||||
| GPL14144_Y77E11A.10_1823-1882_0.832_92_A | |||||||||
| GPL19516_CGZ0054859 | |||||||||
| GPL21109_Y77E11A.10 | |||||||||
| GPL8673_Y77E11A_10P00914 | |||||||||
| GPL8673_Y77E11A_10P01434 | |||||||||
| GPL8673_Y77E11A_10P01727 | |||||||||
| Expression_cluster (140) | |||||||||
| Interaction (21) | |||||||||
| Map_info | Map | IV | Position | -19.0809 | Error | 0.101519 | |||
| Positive | Positive_clone | Y77E11A | Inferred_automatically | From CDS info | |||||
| From sequence, transcript, pseudogene data | |||||||||
| Pseudo_map_position | |||||||||
| Reference | WBPaper00005513 | ||||||||
| WBPaper00027531 | |||||||||
| WBPaper00038491 | |||||||||
| WBPaper00055090 | |||||||||
| Remark | Sequence connection from [Kuwabara PE] | ||||||||
| Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | ||||||||
| Method | Gene |
