WormBase Tree Display for Gene: WBGene00000439
expand all nodes | collapse all nodes | view schema
WBGene00000439 | SMap | S_parent | Sequence | C13G5 | |||
---|---|---|---|---|---|---|---|
Identity (6) | |||||||
Gene_info | Biotype | SO:0001217 | |||||
Gene_class | ceh | ||||||
Allele (66) | |||||||
Legacy_information | [C.elegansII] NMK. Encodes predicted homeoprotein, engrailed related.[Kamb et al. 1989] | ||||||
[C.elegansII] NMK. Encodes predicted homeoprotein, engrailed related. [Kamb et al. 1989] | |||||||
Strain | WBStrain00035877 | ||||||
WBStrain00003898 | |||||||
WBStrain00008591 | |||||||
WBStrain00049293 | |||||||
WBStrain00049304 | |||||||
WBStrain00055072 | |||||||
RNASeq_FPKM (74) | |||||||
GO_annotation (20) | |||||||
Ortholog (43) | |||||||
Paralog | WBGene00000462 | Caenorhabditis elegans | From_analysis | TreeFam | |||
WBGene00007417 | Caenorhabditis elegans | From_analysis | TreeFam | ||||
Structured_description | Concise_description | ceh-16 encodes a homeodomain protein orthologous to Drosophila and vertebrate Engrailed proteins involved in segment and appendage development; ceh-16 is an essential gene required for proper specification and differentiation of the lateral seam cells during embryonic development; in specifying seam cell fates, CEH-16 appears to act as a transcriptional regulator, repressing expression of the eff-1 gene required for cell fusion and inducing expression of seam cell-specific genes such as elt-5/GATA, nhr-73, and nhr-74; in addition, during post-embryonic development, ceh-16 functions to regulate the expansion division of the epidermal seam cells that occurs during the L2 larval stage; in regulating the expansion division, ceh-16 interacts genetically with apr-1, a member of the Wnt signaling pathway that encodes the C. elegans APC ortholog; a rescuing CEH-16::GFP fusion protein is first expressed in the early embryo in cells of the AB lineage; in later embryonic stages CEH-16::GFP is seen in all lateral seam cell nuclei as well as in some anterior neurons; during post-embryonic development, CEH-16::GFP is expressed in the DA1 and DD1 motor neurons. | Paper_evidence | WBPaper00024903 | |||
WBPaper00034732 | |||||||
Curator_confirmed | WBPerson48 | ||||||
WBPerson1843 | |||||||
Date_last_updated | 03 Jan 2011 00:00:00 | ||||||
Automated_description | Enables sequence-specific DNA binding activity. Involved in several processes, including embryonic body morphogenesis; epidermal cell fate specification; and regulation of transcription by RNA polymerase II. Located in nucleus. Expressed in several structures, including ABarpa; AIZ; hyp5; retrovesicular ganglion neurons; and seam cell. Human ortholog(s) of this gene implicated in Parkinson's disease and autistic disorder. Is an ortholog of human EN1 (engrailed homeobox 1) and EN2 (engrailed homeobox 2). | Paper_evidence | WBPaper00065943 | ||||
Curator_confirmed | WBPerson324 | ||||||
WBPerson37462 | |||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||
Disease_info | Potential_model | DOID:14330 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:3342) | ||
DOID:12849 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:3343) | ||||
Molecular_info (7) | |||||||
Experimental_info | RNAi_result (14) | ||||||
Expr_pattern (20) | |||||||
Drives_construct (13) | |||||||
Construct_product | WBCnstr00005599 | ||||||
WBCnstr00005670 | |||||||
WBCnstr00011405 | |||||||
WBCnstr00013434 | |||||||
WBCnstr00016073 | |||||||
WBCnstr00016562 | |||||||
WBCnstr00016869 | |||||||
WBCnstr00019258 | |||||||
WBCnstr00037538 | |||||||
Antibody | WBAntibody00000835 | ||||||
Microarray_results (21) | |||||||
Expression_cluster (113) | |||||||
Interaction (97) | |||||||
Anatomy_function | WBbtf0067 | ||||||
Map_info | Map | III | Position | -0.216271 | Error | 0.001861 | |
Positive | Positive_clone | C13G5 | Inferred_automatically | From sequence, transcript, pseudogene data | |||
CF#EN2 | |||||||
Mapping_data | Multi_point | 5618 | |||||
Pseudo_map_position | |||||||
Reference (29) | |||||||
Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||
Method | Gene |